The Yaden Lab studies psychedelic & other altered states of consciousness. In the Johns Hopkins Center for Psychedelic & Consciousness Research @JHPsychedelics
Johns Hopkins University
Joined April 2014
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Yaden Lab retweeted
• Coping strategies: 30% had tried supplements (mostly NAC, acetyl-L-carnitine, magnesium), and interestingly 5% used antidepressants specifically to cope, hinting at preclinical findings on SSRIs mitigating MDMA-induced depletion of serotonin
Yaden Lab retweeted
‼️ New paper! MDMA "blue Mondays" & "suicide Tuesdays" are familiar phrases in recreational MDMA culture, describing low points in the days post-use. But do these aftereffects actually exist? Current research shows conflicting results. Thread👇
Yaden Lab retweeted
🔬 As MDMA-assisted therapy keeps moving toward the clinic, understanding what happens post-treatment matters. So, we (@kelcy_audra, @ExistWell, & @sdpnayak) surveyed 497 US adults with MDMA experience to better understand the phenomenon. Some takeaways:
Yaden Lab retweeted
Open-access link: jmepb.bmj.com/content/2/4/e0…
Yaden Lab retweeted
A growing body of bioethical work has examined ethical issues related to the use of psychedelics in clinical research. With @eddietalksdrugs and @ExistWell, we try to take stock in our state-of-the-field review, published in JME Practical Bioethics.
Yaden Lab retweeted
Had a great time helping represent @TheYadenLab and @JHPsychedelics yesterday at the @FDA's public hearing on psychedelics' therapeutic potential -- big things on the horizon
Representing @TheYadenLab at @JHPsychedelics & @psychedelethics at @FDA. Postdoc Eddie Jacobs @eddietalksdrugs spoke to how the evidence on psychedelic treatments comes from clinical trials, so those safeguards should be used for initial roll-out, to be adjusted based on data…
Yaden Lab retweeted
The first completely on-site preclinical animal study from @JHPsychedelics.
An immensely valuable collaboration with Division of Behavioral Biology. So grateful that I got to lead it and work with what can only be called the dream team!
Unroll the tweet below for deets 📜
New paper led by @PraachiTiwari, a former postdoc in @TheYadenLab, now faculty at Div of Behavioral Bio & @JHPsychedelics (also w/ @CassieMoorePhD, Brian Jenkins, Elise Weerts, me).
We examined how psilocybin affects a broader range of spontaneous behaviors in rats than HTR...
Yaden Lab retweeted
The first full year of data collected under SB 303 from Oregon's psilocybin services was recently published.
With @CaleighPropes & @ExistWell, we examine this data to give a preliminary picture as to how safety and access are being balanced in Oregon’s psilocybin services.
Yaden Lab retweeted
Trial safety data won't transfer cleanly to routine care, and we can't with confidence know which safeguards contribute to it. Record how clinics vary in practice, collect evidence of outcomes, and specify review points and evidential thresholds for loosening safeguards
Yaden Lab retweeted
Meeting with scientists, clinicians, and bioethicists at @JHUBloombergCtr to discuss practical ethical guidelines for clinical applications of psychedelics. Meeting led by @eddietalksdrugs & @Katherine_Chg with @briandavidearp and I glad to see @psychedelethics doing applied work
Yaden Lab retweeted
New paper led by @PraachiTiwari, a former postdoc in @TheYadenLab, now faculty at Div of Behavioral Bio & @JHPsychedelics (also w/ @CassieMoorePhD, Brian Jenkins, Elise Weerts, me).
We examined how psilocybin affects a broader range of spontaneous behaviors in rats than HTR...
Yaden Lab retweeted
From 144(!) items, to just 14 plus three stand-alone items.
We validated this using factor analysis (initial factor structure did not replicate), qualitative procedures to ensure participants understand items, and getting near identical results b/w long and short form in trials
Yaden Lab retweeted
New paper, by me & @r_ehrenkranz (former postdoc at @TheYadenLab, now asst prof of biostats at @NorthwellHealth): We validated & shortened the Persisting Effects Questionnaire (PEQ), used to measure pos and neg changes after psychedelic exp-144 items to 14, w/ 3 stand-alone items
New paper – Validating and Creating a Short-Form of the Persisting Effects Questionnaire: A Measure of Positive and Negative Outcomes from Psychedelic Experiences
The Persisting Effects Questionnaire (PEQ) is a measure of self-reported positive and negative effects from psychedelic experiences. While commonly used, the PEQ has never been formally validated, and is time-intensive and complex for both participants and researchers.
Using a multi-study approach, CPCR researchers created and validated the Persisting Effects Questionnaire – Short Form (PEQ-SF), a scale that is more easily understood and reduces burden for study teams and participants.
Read the paper here: journals.sagepub.com/doi/10.…
Yaden Lab retweeted
Eddie Jacobs PhD @eddietalksdrugs representing @TheYadenLab, @JHPsychedelics, @psychedelethics–and I think the consensus of many psychedelic scientists–at @FDA
Any clinical application of psychedelics should, at least initially, use safeguards based on the clinical trial context
Representing Dr. David Yaden's (@ExistWell) lab @TheYadenLab at the CPCR & @psychedelethics at @FDA — see Postdoc Eddie Jacobs, PhD (@eddietalksdrugs) from the FDA public hearing this week on the importance of implementing safeguards based on standardized evidence on psychedelic treatments in clinical trials.
Yaden Lab retweeted
New paper – Validating and Creating a Short-Form of the Persisting Effects Questionnaire: A Measure of Positive and Negative Outcomes from Psychedelic Experiences
The Persisting Effects Questionnaire (PEQ) is a measure of self-reported positive and negative effects from psychedelic experiences. While commonly used, the PEQ has never been formally validated, and is time-intensive and complex for both participants and researchers.
Using a multi-study approach, CPCR researchers created and validated the Persisting Effects Questionnaire – Short Form (PEQ-SF), a scale that is more easily understood and reduces burden for study teams and participants.
Read the paper here: journals.sagepub.com/doi/10.…
Yaden Lab retweeted
Representing Dr. David Yaden's (@ExistWell) lab @TheYadenLab at the CPCR & @psychedelethics at @FDA — see Postdoc Eddie Jacobs, PhD (@eddietalksdrugs) from the FDA public hearing this week on the importance of implementing safeguards based on standardized evidence on psychedelic treatments in clinical trials.
Yaden Lab retweeted
Just 3 more weeks to sign up for our CME/CE course! The CPCR faculty led course will provide an evidence-based introduction to psychedelic medicine, covering patient engagement, emerging research, and the future of psychedelic-assisted care. Register at tinyurl.com/jhucme
📚 Earn up to 6.5 CME/CE credits
📅 October 9, 2026 | Online | 8:45am–4:30pm ET
Yaden Lab retweeted
Went with @TheYadenLab to speak to the @FDA about the rollout of #psychedelics and listen to other stakeholders. 120s speaking time boiled down even further: ...
Yaden Lab retweeted
He also cited our @JAMAPsych article by our group (w/ Jared Hinkle @MariannaGrazz @sdpnayak me) showing that psychedelics do sometimes result in serious adverse events (4% in neuropsychiatric populations)-important to remember alongside the real benefits
jamanetwork.com/journals/jam…
