Structural biology lab @Bio21Institute @UniMelb led by Mike Griffin.
Victoria, Australia
Joined February 2019
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Griffin Lab retweeted
Excited to see our study published in @PLOSPathogens. Multi-stage activity & single oral dose killing of P. falciparum in vivo. Structural basis for improved potency and selectivity of this reaction-hijacking inhibitor are revealed. doi.org/10.1371/journal.ppat…
Griffin Lab retweeted
💀The Garbers team @MHH_life characterise two clinically relevant variants in the #Interleukin-11 receptor gene & their roles in premature closure of 💀 bone sutures:
💀 buff.ly/3WgYjC7
🔆 Commentary by @NatalieASims: buff.ly/3Wc07wh
#craniosynostosis
Griffin Lab retweeted
SAVE THE DATE! Excited to announce the 22nd Melbourne Protein Group Symposium will be hosted at WEHI on Thursday 11th July 2024. Spread the word to other graduate research/ student colleagues. Details of keynote speakers and abstract submission to come.
Griffin Lab retweeted
Don't miss out on your opportunity to attend and participate in Biomolecular Horizons 2024, held in Melbourne!
YOUNG SCIENTIST PROGRAM- LAST CHANCE- application deadline extended to Friday 8 March @bmh2024Melb
bmh2024.com/young-scientist-…
Great fun to work with @NatalieASims reflecting on new insights from the Garbers lab doi.org/10.1111/febs.1…, and open questions still to be answered surrounding craniosynostosis-associated variants in the IL-11 signalling machinery!
febs.onlinelibrary.wiley.com…
Interleukin 11 (IL-11) receptor complex mutations are associated with craniosynostosis, but how does it happen? @The_GriffinLab and I had fun writing this editorial for @FEBSJournal based on new work from the Garbers lab - so much more to learn! febs.onlinelibrary.wiley.com…
Great to see this beautiful work published today. And wonderful to be part of the global team advancing this amazing program!
nature.com/articles/s41467-0…
#Malaria parasites are specifically targeted by a new class of reaction-hijacking inhibitors. Targeting a tRNA charging enzyme, #OpenSourceMalaria compound causes parasites to self-destruct. An amazing collaborative effort from multiple sites across the globe. #Drugs #Parasites.
Really proud of this work published today understanding the assembly of the IL-11 signalling complex, dynamics of the gp130 receptor subunit, and how to inhibit IL-11 signalling. A brilliant collaboration! @riley_dm, @big_french_man, @PutoczkiLab.
doi.org/10.1038/s41467-023-4…
Congratulations Riley! Was quite a journey to get this out there - a huge credit to Riley for his hard work and determination.
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Griffin Lab retweeted
Excited to share our reviewed preprint on a TRAP transporter doi.org/10.7554/eLife.92307.… in @eLife where an unexpected dimeric assembly was used to obtain a high-resolution structure. Big thanks to Michael Currie, @_jamesdavies and @dobson_lab, along with our fantastic collaborators!
Griffin Lab retweeted
I am pleased that our review entitled: Targeting Aminoacyl tRNA Synthetases for Antimalarial Drug Development, in Annual Review of Microbiology is now available Open Access. doi/10.1146/annurev-micro-032421-121210. @WinzelerLabUCSD @The_GriffinLab @IRBBarcelona @MalariaPapers
Griffin Lab retweeted
Open for registration. @RACI_VIC and MPG joint conference. To be held @RMIT. Register now CHEM 2023 / MPG (raci.org.au) and submit abstracts by 22nd Sept forms.gle/Xr3yp8xHeVnboST66. Lots of speaking slots for #students and #ECRs
Griffin Lab retweeted
Excited to see our #malaria pre-print dx.doi.org/10.21203/rs.3.rs-…. An amazing collaborative effort from many sites across the globe to define the mechanism of action of a promising new class of reaction-hijacking inhibitors, targeting a tRNA charging enzyme in malaria parasites.
Griffin Lab retweeted
We have a position open in the lab to take care of our SEMs and EDS workflow. @Bio21Institute @UniMelb Details : Technical Officer, Scanning Electron Microscopy jobs.unimelb.edu.au/en/job/9…
Congratulations Cameron on a great PhD oration today!! @Bio21Institute @UniMelbMDHS @hayleyjnewton
Griffin Lab retweeted
A thoughtful commentary on our nucleoside sulfamate antimalarial work and an insightful reflection on the history of nucleoside-based anti-infectives. I loved reading about the contributions of Gertrude Elion. cell.com/cell-host-microbe/f…. @odomjohnlab @SeshMDPhD #malaria
Griffin Lab retweeted
Adenosine sulfamates: Next generation of #antimalarials. @odomjohnlab @SeshMDPhD highlight recent work of @LeannTilley @ScienceMagazine uncovering a class of nucleoside analogs that selectively hijack & inhibit tyrosine tRNA synthase of #malaria parasite cell.com/cell-host-microbe/f…
Fantastic to see this work identifying a new antimalarial strategy published. Proud and privileged to lead the structural biology with a global team headed up by Prof. @LeannTilley. Congratulations to all involved!
@UniMelb @Bio21Institute @TakedaPharma
science.org/doi/epdf/10.1126…
Now highlighted in @TrendsParasitol:
Thwarting protein synthesis leads to malaria parasite paralysis
authors.elsevier.com/a/1fPle…
Griffin Lab retweeted
Drs Godfrey Mayoka @jgwoodland & @Kelly_Chibale highlight Alexandra Gould @LeannTilley & colleagues’ recent @ScienceMagazine paper in this Spotlight: Thwarting protein synthesis leads to malaria parasite paralysis. @UCT_news @H3D_UCT @DiscoverJKUAT
authors.elsevier.com/a/1fPle…
Super happy to get this work out there at last!!! Beautiful structures and elegant mechanistic analysis - Great work @riley_dm and @big_french_man!!
biorxiv.org/cgi/content/shor…