@TimCKenny

Assistant Professor interested in nutrient transport and metabolism at @SinaiHeartBlood @IcahnMountSinai by way of @RockefellerUniv @GradSchoolSinai @BucknellU

 New York, NY
timothyckennylab.com/
Joined May 2019
  • Tweets156
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  • Followers582
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Our graduate student @YuyangLiu1996 just opened his lab as a Sandler Fellow at @UCSF . Looking forward to many discoveries from Yuyang, an incredibly creative scientist: physiology.ucsf.edu/content/… @RockefellerUniv
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🩸🩸🩸TODAY WE SHARE TWO MAJOR DISCOVERIES🩸🩸🩸 1. We peered into genomes and brains of rare mosquitoes that QUIT feeding on blood and found what biting is built from 2. Humans got rid of isoleucine in their blood, malaria suffers from it, and mosquito proteomes budget for it
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We found an adrenergic iron–MSRA axis that regulates methionine redox signaling and adipose browning. Disrupting MSRA preserved tissue mass and prolonged survival in tumor-bearing mice. Huge congrats to Jung Seung Nam, who led this work! nature.com/articles/s43018-0…

An iron-regulated methionine redox axis governs adipose browning and cancer cachexia

Nature Cancer - Chio and colleagues describe an iron-dependent pathway with a role in the induction of cancer cachexia-linked events such as adipose browning and identify methionine sulfoxide...

nature.com
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Thrilled to share I’ve joined @YaleCellBio as an Assistant Professor after an incredible postdoc in the @KivancBirsoy Lab at @RockefellerUniv. Excited to launch the Liu Lab website: shanshanliulab.com/, built by @oopslabai. Thank you for bringing our lab vision to life!

Liu Lab | Metabolic Homeostasis in the Secretory Pathway

The Liu Lab studies metabolic homeostasis in the secretory pathway using ER-IP, genetics, and metabolomics.

shanshanliulab.com
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As we approach the six-month mark since opening our doors, I'm excited to share our lab website and introduce our team at @SinaiHeartBlood @IcahnMountSinai. Check out what we've been up to and reach out if you're interested in joining us or collaborating! timothyckennylab.com

Timothy C. Kenny Laboratory

timothyckennylab.com
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Tim Kenny retweeted
Deepak Kaji@deepak_kajiMay 4
I'm excited to announce I'll be starting the Kaji lab at @MountSinaiPsych in July. The lab will employ multiomic (snRNAseq, snATACseq, and spatial transcriptomics) and electrophysiology study brain development and disease. Grateful for all the help along the way!
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Our new work by @shanshanliu1218 and @gadmark addresses a fundamental question: how does ER maintain its unique oxidizing environment, while rest of the cell is reducing? Here, we identify SLC33A1 as the major ER GSSG exporter in mammalian cells. nature.com/articles/s41556-0…

SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis

Nature Cell Biology - Liu, Gad et al. develop an approach to purify the endoplasmic reticulum and integrate genetic, structural, molecular and cell biological analyses to identify SLC33A1 as an...

nature.com
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Tim Kenny retweeted
Gad@gadmarkApr 17
Thrilled to share our new paper: SLC33A1 is the long-sought ER GSSG exporter, maintaining redox homeostasis in the ER. Huge congratulations to my co-first author @shanshanliu1218 and my PIs @KivancBirsoy and @HiteLabMSKCC for leading this work. nature.com/articles/s41556-0… 🧵 1/9

SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis

Nature Cell Biology - Liu, Gad et al. develop an approach to purify the endoplasmic reticulum and integrate genetic, structural, molecular and cell biological analyses to identify SLC33A1 as an...

nature.com
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Excited to share that my PhD work on ER mito contact sites is finally out at @MolecularCell! Big shout out to @stark2_d to take this across the finish line, and @YatrikShahLab and @LyssiotisLab for their guidance as always!
Molecular Cell@MolecularCellFeb 13
Online Now: BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes dlvr.it/TQxTPQ
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Fil Swirski@SwirskiLabFeb 9
Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart: Immunity cell.com/immunity/fulltext/S…

Influenza hijacks myeloid cells to inflict type-I interferon-fueled damage in the heart

Respiratory infection and cardiovascular disease risk are tightly intertwined clinically, but the mechanisms of this relationship are largely unknown. Here, Downey et al. reveal how influenza...

cell.com
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Excited to share our work on discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid import and carnitine biosynthesis. @Cell_Metabolism @RockefellerUniv cell.com/cell-metabolism/ful…

Machine-learning-guided discovery of SLC25A45 as a mediator of mitochondrial methylated amino acid...

Khan et al. apply machine learning to identify substrates of UNC93A, SLC45A4, and SLC25A45. Biochemical assays and in vivo metabolite tracing establish SLC25A45 as a key mediator of mitochondrial...

cell.com
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New work from our lab describing a role for mitochondrial glutathione in breast cancer metastasis ⁦@nicoledelgaudio⁩ ⁦@RockefellerUniv⁩ aacrjournals.org/cancerdisco…
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Honored to be named a 2025 Pew-Stewart Scholar for Cancer Research. Grateful for the support and excited for the science ahead! pew.org/en/projects/pew-stew…

Directory of Scholars

pew.org
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Thrilled to announce that I will be joining the Cardiovascular Research Institute at @IcahnMountSinai as an Assistant Professor in January! My laboratory will focus on nutrient transport and cellular metabolism in physiology and disease.
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Big thank you to my mentors, institutions, and funding throughout my training @KivancBirsoy, @RockefellerUniv, Doris Germain, @GradSchoolSinai, @NIH @theNCI @NIDDKgov
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Finally, thank you to my recruiters and soon to be colleagues @SwirskiLab @EricJNestler @MiriamMerad @cam_phd @GoedekeLeigh @daniel_puleston. I am so excited to join! I will be hiring at all levels so please reach out if you are interested!
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My lab's first paper is out in @Nature. We show that lipoprotein uptake protects tumors from ferroptosis by delivering the lipid antioxidant α-tocopherol. Surprisingly, tumors use sulfated glycosaminoglycans—not canonical receptors—to capture lipoproteins. nature.com/articles/s41586-0…

Glycosaminoglycan-driven lipoprotein uptake protects tumours from ferroptosis

Nature - Lipoprotein uptake dependent on sulfated glycosaminoglycans linked to cell-surface proteoglycans is a key determinant of ferroptosis sensitivity in cancer.

nature.com
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Excited to share our perspective on solute carrier transporters - gatekeepers of metabolism sciencedirect.com/science/ar… @KivancBirsoy @YuyangLiu1996 @gadmark @TimCKenny @CellCellPress @RockefellerUniv
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Choline was first described nearly 175 years ago but our understanding of this essential metabolite is still coming into focus. Excited to share our perspective ⁦@NatMetabolism⁩! ⁦@samscharenberg⁩ ⁦@abu_remaileh⁩ ⁦@KivancBirsoy⁩ nature.com/articles/s42255-0…

Cellular and organismal function of choline metabolism

Nature Metabolism - Kenny and Scharenberg et al. provide a broad overview of the fundamental aspects of choline metabolism and cellular handling, and how it impacts physiology and pathology.

nature.com
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Feel privileged to have had a front row seat to this amazing story by @EriDalla @JAguirreGhiso and colleagues focused on understanding the microenvironmental determinants of cancer cell colonization at metastatic sites with important implications for therapy. Congrats to all!
Erica Dalla@EriDalla7 Oct 2024
Excited to share my PhD thesis work with @JAguirreGhiso out today in @CellCellPress. Big thank you to @micpapanicolaou for bringing this across the finish line and to all our collaborators, especially @MatthewD_Park @MiriamMerad and @Casanova_Acebes! cell.com/cell/fulltext/S0092…
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