Drug Development | MD DPhil (Ox) | Ex-VC Fellow @ArtisVentures
Joined May 2023
- Tweets35
- Following208
- Followers77
- Likes94
Tom Thomas retweeted
The career question I get asked the most is “why did I become a Physician-Scientist” - too often I give a vanilla answer to this - some colleagues have a Eureka moment- for me it was uncertainty, failure & extraordinary mentorship that set me on my journey nature.com/articles/s43018-0…
Tom Thomas retweeted
NICE says genetic testing before initiating clopidogrel is a cost-effective use of NHS resources for patients at risk of stroke
pharmaceutical-journal.com/a…
Tom Thomas retweeted
Today's #JEMLegacy @JExpMed highlights the work of Fiona Powrie @powrie_lab & colleagues showing #Treg cells constitutively express #CTLA-4 and signaling via CTLA-4 is essential for their function to control intestinal inflammation. doi.org/10.1084/jem.192.2.29…
Tom Thomas retweeted
Proud to be part of Dexter, as a tool for clinical trials. Dexter can help with quality improvement, predictive analytics and informatics consult in addition to observational studies and clinical trials. @KrishnaGokhale @UoB_IAHR @HDR_UK @JohtChandan
Proud to celebrate #CTD2023
@unibirmingham has a strong heritage in innovation and clinical trial research. Professor Krish @Nirantharakumar explains how a new software called Dexter can benefit patients by fine-tuning clinical trial design. More at bit.ly/45af6J5
Tom Thomas retweeted
Please check out my paper on healthy synovial fibroblasts and the role of cortisol signaling, now on Bioarchive. Much thanks to all my co-authors!! @ilyakorsunsky
@lynchielydia @AHelenaJonsson1 @FanZhang_Jessie @soumya_boston biorxiv.org/content/10.1101/…
Tom Thomas retweeted
Do T cells remember what we eat? In @JExpMed, Lockhart, @danmucida et al @RockefellerUniv show that physiological exposure to food protein drives CD4+ T cell accumulation, clonal selection, and transcriptional adaptation at the intestinal epithelium. bit.ly/458bZS3
Tom Thomas retweeted
Excited to share another Bioinformatician position in our lab based on our recent fundings!! Great opportunity to develop computational AI methods for longitudinal #SingleCell omics for translational medicine! cu.taleo.net/careersection/2… @CUBiomedInfo @CURheumatology DM me directly🙌 – at Denver, CO
Tom Thomas retweeted
To celebrate the release of THE BOOK THAT WOULDN'T BURN...
...everyone who retweets this g̷e̷t̷s̷ ̷a̷ ̷c̷a̷r̷ ... I mean is in the draw for a signed, dedicated copy ... I'll even number it for you!
Similar scale work needed in the Indian subcontinent as well given rising incidence rates!
Congrats on this groundbreaking work!!! @BDYE_IBD #HosuLee #KyuyoungSong @doc_ibd @JudyCho7 @AsanIbd @NatureGenet nature.com/articles/s41588-0…
Tom Thomas retweeted
Fascinating new preprint on bioRxiv tackles a whale of a question:
Whales are huge. So why don’t they get a ton of cancers?
biorxiv.org/content/10.1101/…
Tom Thomas retweeted
Very happy to announce that today two papers on #PhIPSeq in (1) the general population (🧵 by @sea_andreu) and (2) in patients with inflammatory bowel diseases (#IBD), got published today in @ImmunityCP authors.elsevier.com/c/1h2md…
doi.org/10.1016/j.immuni.202… 🧵 on IBD findings:
Tom Thomas retweeted
#Macrophages in the synovial lining niche initiate #neutrophil recruitment and articular #inflammation, say Kristina Zec, Irina Udalova et al. @UdalovaLab @KirOxford bit.ly/3LD9qzx
#arthritis
Tom Thomas retweeted
We are thrilled to share the first publication from the McAlpine lab! Out today in @ImmunityCP.
“Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis”
@IcahnMountSinai @SinaiHeartBlood @SinaiBrain
cell.com/immunity/fulltext/S…
Tom Thomas retweeted
Wow... 80% of genes are differentially expressed in living versus post-mortem prefrontal cortex tissue. Importantly implications for studying the 'living' biology of the human brain, rather than heavy reliance on what post-mortem tissue shows us. medrxiv.org/content/10.1101/…
Longitudinal scRNAseq in biologic naive patients with IBD - adalimumab:
biorxiv.org/content/10.1101/…
This work was made possible by patients and clinical colleagues at the TGU(Oxford), QEHB(Bham), colleagues @KirOxford,@HumanGeneticsOx ,@celsiustx who helped deliver despite COVID
Many thanks to Charlotte Rich-Griffin, Mathilde Pohin, Matthias Friedrich,@DominikAschenb2
@a_filer,@powrie_lab, Holm Uhlig, Simon Travis, @CalliDendrou, @arthritisbham and colleagues
Also worth checking out some other pre-prints! biorxiv.org/content/10.1101/…
biorxiv.org/content/10.1101/…