@Topo_Lab

@VanderbiltU lab focused on the molecular✂️ known as type II topoisomerases. Account is student run.

 Nashville, TN
lab.vanderbilt.edu/osheroff
Joined February 2019
  • Tweets121
  • Following160
  • Followers233
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Microbe of the month: Pseudomonas aeruginosa dlvr.it/Sztxjm
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Please mark you calendar for a special @VandyBiochem seminar! A colleague of Dr. Neil Osheroff (@Topo_Lab), Dr. Gabriel Frank (@bengurionu) presents "Determining the structure of the seminal biomineral/protein interface by cryo-EM” Tuesday, March 8, 11:00 pm CT, 618 Light Hall
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<2 weeks left to apply for Asst. Prof. positions in the Dept. of Biochemistry at Vanderbilt University. Great opportunity to establish a research program focused on molecular mechanisms of biological processes. apply.interfolio.com/94568 @VUBasicSciences @VandyBiochem Please RT
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My first first-author paper is up on bioRxiv! Feel incredibly grateful to all the help I've gotten along the way. Thanks @JamesMDewar @davidkcortez @Topo_Lab + my lovely Dewar lab members (@TKavlashvili @LillianVCampos )
Dewar Lab@Dewar_Lab14 Oct 2021
Our first foray into bioRxiv! We're really surprised that these chemotherapeutics inhibit DNA replication in such different ways. Graduate student @sabrinadoessci1 did an amazing job. Incredibly grateful to collaborators in Neil Osheroff and @davidkcortez. 💊🛑🧬🐸
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Just won best poster at #EMBO DNA Topology meeting! @LillianVCampos showed great work as well. I feel really grateful and excited. Will hopefully share soon my project work in @Dewar_Lab, with collaboration with @davidkcortez and @Topo_Lab! 🐸🧬
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A collaboration between the @Townsend_Lab & the @Topo_Lab has resulted in a group of compounds with increased cytotoxicity and decreased cardiotoxicity. These compounds can make for improved anti-cancer therapies with less damage to the ❤️ @ACSCentSci news.vanderbilt.edu/2021/07/…
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Congratulations Neil Osheroff, elected to AAMC council leadership post! Read all about it: bit.ly/3eQ2azH @Topo_Lab @AAMCtoday
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We’re recruiting! The Brown lab has a Postdoc opening to investigate the molecular and structural basis for protein assembly. Expertise in cryo-EM and/or cell biology is strongly preferred. Please RT! lab.vanderbilt.edu/brown-lab…

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The Brown Lab is interested in understanding how aberrations in macromolecular protein assembly underlie human diseases. Our primary focus is using structural biology to understand the shape and...

lab.vanderbilt.edu
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Neil Osheroff (@Topo_Lab) at @VanderbiltU highlights the work from the Korn Lab @UChicago on the mediated #cellular response to camptothecin by #lipid-derived #electrophiles generated from drug-induced #oxidative stress dlvr.it/S1x7Ck
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A new @BiochemistryACS review by @topoisomeracer (@Topo_Lab) covers the basics of DNA topoisomerases, focusing on the type II enzymes. Check it out to learn how various anticancer drugs, dietary compounds, and environmental poisons act on topoisomerases. doi.org/10.1021/acs.biochem.…

Topoisomerase II Poisons: Converting Essential Enzymes into Molecular Scissors

Abstract. The extensive length, compaction, and interwound nature of DNA, together with its controlled and restricted movement in eukaryotic cells, create

pubs.acs.org
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A new article from Neil Osheroff (@Topo_Lab) et al in the journal Biochemistry describes the structure and catalytic mechanism of eukaryotic type II topoisomerases and converting essential enzymes into "molecular scissors": bit.ly/2Ta1WeN @ACSPublications
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Check out this research article just published in @ChemResTox by the Neil Osheroff lab, "1,2-Naphthoquinone as a Poison of Human Type II Topoisomerases": bit.ly/31i1jQX @Topo_Lab @ACSPublications
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Osheroff Lab retweeted
Jessica@relaxedchromies24 Mar 2021
My FIRST, first-author paper “1,2-Naphthoquinone as a Poison of Human Type II Topisomerases” was published today in @ChemResTox! So grateful for everyone in @Topo_Lab for their support and encouragement ❤️ pubs.acs.org/doi/10.1021/acs…

1,2-Naphthoquinone as a Poison of Human Type II Topoisomerases

Abstract. 1,2-Naphthoquinone, a secondary metabolite of naphthalene, is an environmental pollutant found in diesel exhaust particles that displays cytotoxi

pubs.acs.org
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Postdoc positions available! We are looking for enthusiastic structural biologists to study mechanisms of replication fork reversal and excision repair of interstrand DNA crosslinks. Vanderbilt has an exceptional genome maintenance community and training environment. Please RT.
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Proud of this one - high resolution AFM and MD describe supercoiled DNA in synergy - tweet thread incoming! – at Two Dales, England
Nature Communications@NatureComms16 Feb 2021
Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides @alicepyne @msesheffield @ANoyLab @PhysicsatYork go.nature.com/3rTwk8Y
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Postdoc position to determine structures of nucleotide excision repair (NER) complexes by EM and use fragment-based inhibitor discovery to suppress NER, for testing as an aid to cancer treatments with DNA damaging therapies. Come join the exciting cancer biochem. community at VU.
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My lab has multiple openings (research assistant, postdoc and staff scientist). Vanderbilt is a wonderful place to work and train. Great group of genome maintenance research colleagues, exceptional infrastructure, and strong career development activities. Please RT.
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Check out our J Med Chem paper on novel and highly selective anticancer inhibitors. Great collab @Topo_Lab⁩ ! ⁦@ACSPublications⁩ ⁦@IITalk⁩ ⁦@AIRC_it A Novel, Potent, and Druglike Inhibitor Highly Selective for Topoisomerase II α over β pubs.acs.org/doi/10.1021/acs…

Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human...

Abstract. We disclose a novel class of 6-amino-tetrahydroquinazoline derivatives that inhibit human topoisomerase II (topoII), a validated target of antica

pubs.acs.org
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The first paper from my lab is out! pubmed.ncbi.nlm.nih.gov/3304…

The SWI/SNF ATPase BRG1 stimulates DNA end resection and homologous recombination by reducing...

DNA double strand breaks (DSBs) are among the most toxic DNA lesions and can be repaired accurately through homologous recombination (HR). HR requires processing of the DNA ends by nucleases (DNA end...

pubmed.ncbi.nlm.nih.gov
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Hi #BlackinPhysio! My name is Tiffany and I am a pancreatic physiologist at @BiomedVandy @VanderbiltU studying islet function, diabetes, pancreas innervation, and purinergic signaling. Learn more below. Thanks for organizing #BiPWeek @BlackInPhysio! #BiPOfficialRollout
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