PhD Scholar at @iiscbangalore, Organic Chemistry
Bangalore, India
Joined March 2021
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Tushar Singha retweeted
Super-strained spirocycles meet AI-supported target fishing. ⏹️🤝🎣
We introduce a new class of "super-strained" spirocycles which through AI-supported target fishing (@CASChemistry) were found to be agonists for the sigma-1 receptor. 💊
Now in @angew_chem
Link in comments👇
Tushar Singha retweeted
⚡️Electrifying Pyridine Functionalization: Curious how electrochemistry enables selective C–H and C–X functionalization of pyridines? Read our review @ChemicalScience. Thank you @iiscbangalore @ANRFIndia
🔗doi.org/10.1039/D6SC00233A
Tushar Singha retweeted
Diastereoselective Synthesis of Housanes via the Carbocupration of Cyclopropenes | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/jac…
Tushar Singha retweeted
Human flight was inspired by birds. Large birds like swans run along the ground or water to build up speed before taking off, and they spread their wings to slow down and land smoothly
Tushar Singha retweeted
🚀Ring-expansion of ketones with [1.1.1]propellane to access functionalized MCB-ketones and spirocyclic scaffolds is out @J_A_C_S. A great collaboration with @MykhailiukChem. Thank you, @ANRFIndia and @iiscbangalore, for the financial support. pubs.acs.org/doi/10.1021/jac…
Tushar Singha retweeted
Cover Page: Our recent work on strain-release functionalization of NAr-BCBS to access spirocyclic sultams has been featured on the cover page of the current issue of Organic Letters. Thank you @JOC_OL @ACSPublications
Tushar Singha retweeted
🦋NAr-BCBS: Our work on strain-release functionalization of N‑aryl bicyclo[1.1.0]butane sulfonamides to access spirocyclic sultams is out in Org. Lett. @JOC_OL. Thank you, @iiscbangalore and @ANRFIndia, for the financial support.
pubs.acs.org/doi/abs/10.1021…
Tushar Singha retweeted
🚀Skeletal editing of ketones using [1.1.1]propellane to access functionalized MCB-ketones and spirocyclic scaffolds is out @ChemRxiv. A fantastic collaboration with @MykhailiukChem. Thank you, @ANRFIndia and @iiscbangalore, for the financial support. chemrxiv.org/engage/chemrxiv…
Tushar Singha retweeted
Access to potential bioisosteres of benzenes by this creative application of strain-release from @HariGroupIISc ⚡️⚡️⚡️ [2,3]-Sigmatropic rearrangement with [1.1.1]propellane | Nature Communications nature.com/articles/s41467-0…
Tushar Singha retweeted
🚀Propellane→MCB→BCH: Our work on the first sigmatropic rearrangement with [1.1.1]propellane for accessing functionalized MCBs and their application in the synthesis of BCHs is out @NatureComms. Thank you, @ANRFIndia and @iiscbangalore, for the funding.
nature.com/articles/s41467-0…
Tushar Singha retweeted
🦋RPC@BCB: Our work on strain-enabled radical-polar crossover annulation to access hetero-bicyclo[3.1.1]heptanes just out in @angew_chem. Thanks to @iiscbangalore and @ANRFIndia for the financial support.
onlinelibrary.wiley.com/doi/…
Tushar Singha retweeted
🏠Housanes: Our work on the stereoselective synthesis of (oxa)housanes and their skeletal remodeling to access bicyclic imides is out in @ChemicalScience. Thank you, @ANRFIndia @iiscbangalore, for the funding.
pubs.rsc.org/en/content/arti…
⚡Check out our work on the electrochemical Interrupted Dowd–Beckwith (IDB) reaction enabling deconstructive functionalization of cyclic ketones.
Deconstruction of Cyclic Ketones: Our work on the electrochemical interrupted Dowd–Beckwith reaction for deconstructive functionalization of cyclic ketones is out in @angew_chem. Thanks to @iiscbangalore and @ANRFIndia for the financial support.
onlinelibrary.wiley.com/doi/…
Tushar Singha retweeted
Deconstruction of Cyclic Ketones: Our work on the electrochemical interrupted Dowd–Beckwith reaction for deconstructive functionalization of cyclic ketones is out in @angew_chem. Thanks to @iiscbangalore and @ANRFIndia for the financial support.
onlinelibrary.wiley.com/doi/…
Tushar Singha retweeted
We finish X with a scientific firework! Very proud of a brilliant team to finally publish our work on C(sp3)-atom transfer @ScienceMagazine ! Thanks to @ERC_Research science.org/doi/10.1126/scie…
Tushar Singha retweeted
Spin State Matters: Our work on the selective generation of triplet carbenes to activate the C–Cl bond of polychloroalkanes is out in @JACS_Au. Thank you, @iiscbangalore @serbonline, for the financial support.
doi.org/10.1021/jacsau.4c009…
Tushar Singha retweeted
Our work on a unified strain-enabled radical-polar crossover annulation strategy to access spiro-, fused-, and enantioenriched-aza/oxa-bicyclo[3.1.1]hepatanes is out @ChemRxiv. Thank you, @iiscbangalore @serbonline, for the financial support.
doi.org/10.26434/chemrxiv-20…
Tushar Singha retweeted
Our work on a highly stereoselective synthesis of densely functionalized housanes and its application in skeletal remodeling to give polysubstituted bicyclic imides is out @ChemRxiv. Thank you, @iiscbangalore @serbonline, for the financial support.
doi.org/10.26434/chemrxiv-20…
Tushar Singha retweeted
#Spirocyclobutanes are highly valued in medicinal chemistry for their diverse biological activities and clinical uses. Leveraging ring strain in small molecules, the Hari group has developed new synthetic strategies to build complex molecules.
👉 thieme-connect.com/products/…
