M.D. Anderson Professor @UHEngineering. Interested in cancer #immunotherapy, #vaccines, #immunology
Houston, TX
Joined February 2020
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Our lab works at the interface of engineering, immunology and immunotherapy.
singlecell.chee.uh.edu/
Our latest work was published in @HoustonChron!
University of Houston nasal vaccine prevents COVID from spreading : houstonchronicle.com/news/ho…
NV Lab retweeted
Dr. Ankita Leekha from the @UH_NVLab led the development of NanoSTING 🦂, a nanoparticle formulation of the endogenous STING agonist, 2′−3′ cGAMP, to function as an immune activator and demonstrated its safety in mice and rats. 🐁 🐀
More here: go.nature.com/4bUds0j
NV Lab retweeted
Many congratulations to our Dr. Sunil Acharya @sunilacharya13 for his exciting research on CD70-targeting CAR NK cells, published in Cancer Discovery! Sunil and his co-authors showed that the incorporation of CD28 costimulation, which is normally absent in NK cells, in the CAR construct improves efficacy of CAR NK cells via the LCK/CD3ζ/ZAP70 pathway. Sincere thanks to our collaborators for their invaluable contributions. We’re excited about the promising clinical trials ahead! @MDAndersonNews #CancerResearch #Immunotherapy #CAR_NKCells @kchenken @UH_NVLab
Now online in @CD_AACR: CD28 Costimulation Augments CAR Signaling in NK cells via the LCK/CD3ζ/ZAP70 Signaling Axis - by @sunilacharya13 @lab_rezvani and colleagues doi.org/10.1158/2159-8290.CD… @MDAndersonNews
NV Lab retweeted
CD28 co-stimulation in NK cells? Who knew! New @CD_AACR paper from @lab_rezvani @MDAndersonNews showing CD28 costimulation can augment CAR signaling in mature NK cells via the LCK/CD3Z/ZAP70 axis.
aacrjournals.org/cancerdisco…
Latest UH press release featuring our new Nature Cancer paper! uh.edu/news-events/stories/2… @UHEngineering @UH_ChBE @UHouston
NV Lab retweeted
Check out the latest articles @NatureCancer "Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling" doi.org/10.1038/s43018-024-0…
Dynamic functional profiling of T-cell therapies uncover a subset of T cells, labeled CD8-fit, that are motile serial killers and are associated with clinical responses in diffuse B cell lymphoma patients.
nature.com/articles/s43018-0…
(No Paywall) singlecell.chee.uh.edu/wp-co…
An intranasal nanoparticle vaccine elicits protective immunity against Mycobacterium tuberculosis @UHEngineering @UH_ChBE sciencedirect.com/science/ar…
NV Lab retweeted
Next - @UH_NVLab @MDAndersonNews @UHouston is telling us about the metabolic plasticity of T-cell Therapies, with an intriguing title, "digest more fat"! @MelanomaReAlli
Understanding redundancies in cytotoxic mechanisms employed by CAR T cells in the killing of tumors @UHEngineering @UH_ChBE
Link: nature.com/articles/s41419-0…
NV Lab retweeted
Congratulations to PhD candidate Melisa Montalvo (advisor: @UH_NVLab) in her first-placr poster award at the @SHPE National Convention!
ALT UH ChBE PhD candidate Melisa Montalvo (second from right) stands with four men and receives a large check as her prize for the first-place poster award at the 2023 SHPE National Convention.
Congratulations to @CellChorus for being announced as a 2023 Houston Innovation Awards finalist in the Life Science Business sector! #startups #innovation #AI #immunology @_danmeyer
Link: houston.innovationmap.com/20…
Trained neural network detects apoptotic bodies of human melanoma cells without fluorescent labeling
@UHEngineering @UH_ChBE #MachineLearning #Immunology
Link: academic.oup.com/bioinformat…
NV Lab retweeted
Celebrating the induction of four of my @UHouston colleagues as senior members of the National Academy of Inventors. Congratulations Navin Varadarajan, @tjmountziaris, James Briggs and Gomika Udugamasooriya
Linking extracellular vesicle (EV) secretion to metastasis at the single-cell level
@MohsenFathi1993 @UH_ChBE @iScience_CP
iScience article: rb.gy/awtmw
NV Lab retweeted
Dr. Navin Varadarajan's team (@UH_NVLab) at @UHouston developed a method to identify 🔎 signatures of #ExtracellularVesicle secretion in metastatic #BreastCancer through functional single-cell profiling.
More in @iScience_CP
💡 bit.ly/3LPADzr
NV Lab retweeted
New tech developed at @UHEngineering shows promise as a weapon against #lymphoma bit.ly/3TgR8VN #nanotech
NV Lab retweeted
(1/2) This issue of #Parameters features stories on @UH_ChBE Prof. Gül Zerze's academic path; new grants for @UH_NVLab (immunotherapy) and @ekourent (diagnostics); an ASEE award for postdoc Dr. LeShorn Benjamin (with @dr_jah_director); awards for Profs. Anil Bhowmick, ...
Today we are excited to launch the fall 2022 issue of #Parameters. In this issue, we highlight some of the rising stars to have recently joined the #CullenCollege, along with their incredible work. ( 1 of 3)
NV Lab retweeted
Incredibly proud of Ye Ethan Li for having his PhD project published in Nat Med. His paper shows that trogocytosis drives relapse post CAR NK therapy & that modulating NK signaling can improve CAR NK efficacy. Congratulations Ethan! @KenChen @UH_NVLab
nature.com/articles/s41591-0…