@UKYCMB

The mission of the Center for Muscle Biology is to support excellence in basic and clinical research in the field of muscle biology.

 Kentucky, USA
uky.edu/chs/muscle
Joined December 2017
  • Tweets249
  • Following121
  • Followers717
26Media
Exciting new study led by Jordan Fuqua of the Miller Lab, in collaboration with our CMB colleague, Dr. Dupont-Versteegden, found impaired proteostatic mechanisms responsible for the limited recovery of old skeletal muscle following atrophy pubmed.ncbi.nlm.nih.gov/3744…

Impaired proteostatic mechanisms other than decreased protein synthesis limit old skeletal muscle...

Our data suggest that the failure of old muscle to recover after disuse is not due to limitations in the ability to synthesize myofibrillar proteins but because of other impaired proteostatic...

pubmed.ncbi.nlm.nih.gov
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An exciting new study led by Drs. Ismaeel and Van Pelt of the Dupont-Versteegden lab of the CMB. nam04.safelinks.protection.o…
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Exciting new study from the Dupont-Versteegden lab led by Dr. Zachary Hettinger of the CMB. physoc.onlinelibrary.wiley.c…

The transcript interactome of skeletal muscle RNA binding protein motif 3 (RBM3)

Skeletal muscle RNA binding protein motif 3 (RBM3) has been recognized as a potential regulator of muscle size, while potential mechanisms are unknown. This study isolates and characterizes the...

physoc.onlinelibrary.wiley.com
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Fantastic new study pubmed.ncbi.nlm.nih.gov/3654… extending earlier work by the Peterson lab led by Dr. Cory Dungan pubmed.ncbi.nlm.nih.gov/3490…

Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration - PubMed

Tissue regeneration requires coordination between resident stem cells and local niche cells1,2. Here we identify that senescent cells are integral components of the skeletal muscle regenerative niche...

pubmed.ncbi.nlm.nih.gov
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nam04.safelinks.protection.o… Findings from TELEX Clinical Trial published in JAMA!! CMB colleagues, Drs. Kosmac & Peterson, members of the research team. 6-month telmisartan treatment did not improve 6-minute walk distance of PAD patients. Muscle data presented at upcoming at AHA conf

Effect of Telmisartan on Walking Performance in Patients With Lower Extremity Peripheral Artery...

This randomized clinical trial compares the effect of telmisartan on 6-minute walk distance compared with placebo in patients with lower extremity peripheral artery disease at 6-month follow-up.

jamanetwork.com
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An exciting new study from the Dupont-Versteegden lab led by Nicholas Thomas. journals.physiology.org/doi/…

Satellite cell depletion does not affect diaphragm adaptations to hypoxia | Journal of Applied...

The diaphragm is the main skeletal muscle responsible for inspiration and is susceptible to age-associated decline in function and morphology. Satellite cells in diaphragm fuse into unperturbed...

journals.physiology.org
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Insightful meta-analysis from CMB colleagues on power training to treat frailty led by Alexander Sklivas and Kirby Mayer. physoc.onlinelibrary.wiley.c…

Efficacy of power training to improve physical function in individuals diagnosed with frailty and...

This systematic review assesses the efficacy of different training methods on chronically ill adults. The goal of this review was to determine if power training was more effective than traditional...

physoc.onlinelibrary.wiley.com
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NIH-supported post-doc to study satellite cell communication during muscle hypertrophy with aging using scRNA-seq, transgenic mice and extracellular vesicles. Contact Charlotte Peterson ([email protected]) or John McCarthy ([email protected]) at the University of Kentucky for details.
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CMB congratulates Zach Hettinger of the Dupont lab for getting the cover of Function. #myotwitter
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Congratulations to our CMB colleagues!! doi.org/10.3389/fphys.2022.8… #myotwitter

Frontiers | Potential Benefits of Combined Statin and Metformin Therapy on Resistance Training...

Metformin and statins are currently the focus of large clinical trials testing their ability to counter age-associated declines in health, but recent reports...

frontiersin.org
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From our CMB colleagues!! physoc.onlinelibrary.wiley.c… #MyoTwitter

Cross Talk proposal: Myonuclei are lost with ageing and atrophy

Click on the article title to read more.

physoc.onlinelibrary.wiley.com
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UKY Center for Muscle Biology retweeted
Kevin Murach@KevinMurachPhD24 Mar 2022
Dr. Cory Dungan with more 🔥 “Senolytic treatment rescues blunted muscle hypertrophy in old mice” in @GeroScienceAge @UKYCMB #myotwitter link.springer.com/article/10…

Senolytic treatment rescues blunted muscle hypertrophy in old mice

GeroScience - With aging, skeletal muscle plasticity is attenuated in response to exercise. Here, we report that senescent cells, identified using senescence-associated β-galactosidase (SA...

link.springer.com
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New study from our colleagues at the University of Kentucky, Center of Muscle Biology: faseb.onlinelibrary.wiley.co…
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More evidence of the importance of macrophages in muscle hypertrophy by Peck et al., of the CMB, “A muscle cell-macrophage axis involving matrix metalloproteinase 14 facilitates extracellular matrix remodeling with mechanical loading” FASEB J doi: 10.1096/fj.202100182RR
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In collaboration with CMB partners, the Lepley lab, using a novel preclinical model of ACL injury, found that neuromuscular communication was disrupted prior to muscle atrophy. journals.physiology.org/doi/…

Temporal disruption of neuromuscular communication and muscle atrophy following noninvasive ACL...

Many patients with anterior cruciate ligament (ACL) injuries have persistent quadriceps muscle atrophy, even after considerable time in rehabilitation. Understanding the factors that regulate muscle...

journals.physiology.org
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UKY Center for Muscle Biology retweeted
Kevin Murach@KevinMurachPhD24 Nov 2021
New from M3R & @UKYCMB feat. @FerdinandvW “Epigenetic Evidence for Distinct Contributions of Resident and Acquired Myonuclei During Long-Term Exercise Adaptation Using Timed In Vivo Myonuclear Labeling” Open Access @AJPCellPhys @APSPublications #myotwitter journals.physiology.org/doi/…

Epigenetic evidence for distinct contributions of resident and acquired myonuclei during long-term...

Muscle fibers are syncytial postmitotic cells that can acquire exogenous nuclei from resident muscle stem cells, called satellite cells. Myonuclei are added to muscle fibers by satellite cells during...

journals.physiology.org
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A new study led by Zach Hettinger of the Dupont-Versteegden lab of the CMB found aging muscle is more susceptible to mechanical-induced injury during recovery from disuse atrophy #myotwitter academic.oup.com/biomedgeron…

Age-Related Susceptibility to Muscle Damage Following Mechanotherapy in Rats Recovering From Disuse...

Abstract. The inability to fully recover lost muscle mass following periods of disuse atrophy predisposes older adults to lost independence and poor qualit

academic.oup.com
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UKY Center for Muscle Biology retweeted
Stuart Phillips (he/him)
@mackinprof26 Oct 2021
Resistance Exercise, Aging, Disuse, and Muscle Protein Metabolism onlinelibrary.wiley.com/doi/… via @james_mckendry @tjstokes5 & @MACleod_JC #goodreads
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NIH-supported post-doc to study the impact of AGING on MUSCLE HYPERTROPHY using scRNA-seq, novel transgenic models, and exosome-related techniques. Contact Charlotte Peterson ([email protected]) or John McCarthy ([email protected]) at the Univ of Kentucky for details. #myotwitter
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UKY Center for Muscle Biology retweeted
SciShow@SciShow2 Oct 2021
Want to get big #gains? A new study suggests the secret is in your gut! youtu.be/fAgIQOTQF-Q
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