Professor of Medicine at Harvard Medical School #Hematology #MedEd Founder of @TheBloodProjec1

Boston, MA
Joined August 2021
ANEMIA CLASSIFICATION
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A sneak peek at what we're planning for The Blood Project's booth at #ASH26! Stop by, pick up a curiosity card, test your knowledge, and explore the fascinating world of blood. We look forward to seeing you there!
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I've been quiet here for a few weeks, immersed in writing The River of Life, a book about blood. Here's a figure from the manuscript. How can someone survive with a hemoglobin of 2.4 g/dL, while another person can be dying from massive blood loss with a normal hemoglobin?
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1/3 WHY TBP? AI may soon be good enough that physicians no longer need to understand something deeply to get the right answer. So how do we train master clinicians in a world where it becomes possible to practice medicine without mastering medicine?
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2/3 Understanding used to come from the work of reaching the answer. With AI, it will increasingly have to be cultivated on purpose. Almost by accident, The Blood Project has been preparing for that world all along. Curiosity. Mechanism. Critical reasoning. Judgment.
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1/2 THE SMOKE ALARM PRINCIPLE Why does the body sometimes seem to overreact? Because the cost of a false alarm may be far lower than the cost of missing a real threat.
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2/2 Better to trigger fever, pain, nausea, cough, or anxiety 100 times unnecessarily than to miss the one threat that matters. Evolution favors alarms that err on the side of caution. Can you think of examples in hematology?
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A FIRST FOR ME TODAY: TRIPLE PICA A patient with iron deficiency reported craving and consuming three different substances: 🧊 Ice ⬜ Chalk 🌱 Peat moss I’m used to pica involving a craving for a single substance, especially ice. Rarely two.
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2/2 Three distinct cravings at the same time? I can’t remember seeing that before. Pica is a wonderfully strange manifestation of iron deficiency.
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William Aird retweeted
1/2 IRON DEFICIENCY IS MORE THAN ANEMIA Anemia gives us a fairly predictable set of symptoms: fatigue, dyspnea, exercise intolerance, palpitations. Iron deficiency is much more colorful: Fatigue Dyspnea Brain fog Pica Restless legs Hair loss And that’s not all...
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1/2 IRON DEFICIENCY IS MORE THAN ANEMIA Anemia gives us a fairly predictable set of symptoms: fatigue, dyspnea, exercise intolerance, palpitations. Iron deficiency is much more colorful: Fatigue Dyspnea Brain fog Pica Restless legs Hair loss And that’s not all...
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2/2 Brittle nails Cold intolerance Pruritus Easy bruising Tinnitus Glossitis Angular cheilitis Iron deficiency isn't simply anemia waiting to happen.
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William Aird retweeted
1/2 THE LOST ART OF THE CLINICAL NOTE Copying and pasting pages of imaging reports into a clinical note doesn’t make the note more thorough. It makes it harder to read. The art of note writing is deciding what matters, synthesizing it, and telling the reader why it matters.
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1/2 THE LOST ART OF THE CLINICAL NOTE Copying and pasting pages of imaging reports into a clinical note doesn’t make the note more thorough. It makes it harder to read. The art of note writing is deciding what matters, synthesizing it, and telling the reader why it matters.
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2/2 A clinical note should be an act of judgment, not data storage.
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POLL FROM CLINIC TODAY Have you ever recommended lactoferrin for treatment of iron deficiency?
1%Yes, routinely
6%Yes, occasionally
27%No, but familiar with it
66%Wait... lacto-what?
160 votes • Final results
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1/5 WHAT IS THE SOCIAL HISTORY FOR? I realized the other day that I’m so programmed to ask every patient whether they smoke and how much alcohol they drink that I feel uncomfortable leaving it out of the history.
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4/5 But should we mechanically re-ask both questions in every subspecialty encounter simply because that’s what we were taught to include in a social history?
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5/5 Every question has a cost: time, attention, and sometimes intrusion. Maybe social history should be problem-oriented, not checkbox-oriented. Ask because the answer might matter, not because the note feels incomplete without it.
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