PhD Candidate, Genetics @ucdavis | Starr–Luxton Lab | Cell Biology × Biophysics | Views my own🌈
Davis, CA
Joined December 2020
- Tweets200
- Following338
- Followers157
- Likes218
Excited to share another chapter of my dissertation! We found that LINC complexes acts as a brake on nucleolar assembly in C. elegans early embryos. Grateful to Dan and Gant, Steph and all other co-authors for making this work possible. biorxiv.org/content/10.64898…
The nucleolus is the largest condensate in the nucleus and the site where ribosomes are built. It has no membrane. It assembles by phase separation, components demixing from the nucleoplasm into a droplet.
So what decides when it forms? 🧵🪱💧
biorxiv.org/content/10.64898…
Proud to see our research featured in @QuantaMagazine!
New in @QuantaMagazine: the science of cytoplasmic crowding. From @LiamHoltLab & @SimoneReber to our discovery that in vivo cytoplasm is 50x more crowded than cultured cells. Thanks @DanStarrUCDavis & @GabrielPopkin quantamagazine.org/the-bioph… #mechanobiology #frontierscience
XIANGYI DING retweeted
Cytoplasmic crowding acts as a porous medium reducing macromolecule diffusion | PNAS pnas.org/doi/10.1073/pnas.25…
XIANGYI DING retweeted
TaoChongBao: A Large-Scale Caenorhabditis elegans Mutagenesis and Missense Variant Database Bridging Worm and Human Genomes biorxiv.org/content/10.64898… #biorxiv_bioinfo
Dear friends at ASCB, I’ll be giving a talk tomorrow at the minisymposium of Structure, Function and Mechanics of Nuclear Envelope, at 11:00 am in Room 118.
Come talk with me and all other Starr-Luxton Lab folks here Matt, Dan and Gant #ASCB #CellBio2025
XIANGYI DING retweeted
Cancer cells are notoriously plastic, but what triggers the changes in cell state? In our new @nature paper, Miranda Hunter found that mechanical pressure is a key to this switch. Check it out here: go.nature.com/47iwDm2
Check out our new preprint!! 🎉 Lamin variants in muscular dystrophy don’t just affect the nucleus — they disrupt a nucleolar–ribosomal axis that reshapes the entire cytoplasm. Very grateful to @DanStarrUCDavis , @gwgl1979 , and our lab team for the collaboration and support!
🧬 NEW Starr-Luxton Lab PREPRINT: Our 🌠grad student @XiangyiDing figured out why muscular dystrophy mutations cause such widespread cellular chaos. The answer wasn't what we expected - and it changes how we think about the disease. Thread🧵 (1/6). biorxiv.org/content/10.1101/…
Excited to share that a big part of my PhD in the Starr–Luxton lab @ucdavis is now published in Science Advances! The cytoplasm of living animal tissues is extremely crowded and constrained — maintained by ribosomes and the giant KASH protein ANC-1.
science.org/doi/10.1126/scia…
Huge thanks to my lab, all the co-authors especially @HongyanHao and @DanielElnatan for their key contribution, my mentors @gwgl1979 @DanielAStarr, our collaborator @LiamHoltLab who made this work possible. Thanks to the @AllenInstitute and @NIGMS for supporting our research!
XIANGYI DING retweeted
🚨Our fabulous graduate student Selin's paper on how the KASH protein UNC-83 regulates the activity of kinesin-1 to control developmental stage-specific nuclear migration is out! Another great collaboration between the Starr-Luxton and MOM labs @ucdavis.
sciencedirect.com/science/ar…
XIANGYI DING retweeted
From MBoC
Improved tools for live imaging of F-actin structures in yeast
Enhanced Lifeact probe drastically increases detection of F-actin in vivo at low expression levels, without altering cellular actin dynamics or organization @BruceLaneGoode
doi.org/10.1091/mbc.E24-05-0…
XIANGYI DING retweeted
Regulation of inflammatory responses by pH-dependent transcriptional condensates: Cell cell.com/cell/fulltext/S0092…
XIANGYI DING retweeted
How does the cell membrane adapt to its environment?
@dnr_robinson and Amy Rowat are developing CRISPR-powered technologies to identify proteins that impact cell membrane mechanics, particularly how membranes adapt to physical stress. #FrontierScience alleninstitute.org/division/…
XIANGYI DING retweeted
Chromatin heterogeneity modulates nuclear condensate dynamics and phase behavior.
Congratulations Jing! Happy to have contributed in a small way to this interesting work!
nature.com/articles/s41467-0…
XIANGYI DING retweeted
Our tour de force into the nucleolar world — a stunning exploration of spatial organization and the functional choreography of ribosome biogenesis now out in Nature✨ tinyurl.com/5n7jk3uz
Led by @sofiquinodoz, @jiang_lifei, @brangwynnelab, with theory partners @QiweiYu2, Andrej Kosmrlj, and all of our collaborators!!
Now on the Princeton Engineering and ODBI sites, a new mapping tool that allows researchers to peer deep into cells' inner compartments to watch and control ribosome assembly, shedding new light on the machinery responsible for making proteins.
ALT The words "New tool allows researchers to track assembly of cells' protein-making machines, image by Holly Cheng" with microscope image of pink and green globules
XIANGYI DING retweeted
Excited that our nucleolus mapping paper just came out today in Nature! Truly an amazing study from even more amazing due of @sofiquinodoz & @jiang_lifei w/ @LafontaineLab & Sebastian Klinge and other fantastic co-authors nature.com/articles/s41586-0…
Excited to share a new preprint!
(1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function?
biorxiv.org/content/10.1101/…
What an honor to deliver my plenary talk at 25th International Worm Meeting #Worm25 plenary session 2 today! Spoke to so many enthusiasts today and collected great questions and insights. I love this community. The Nobel Moment was unforgettable and inspiring. Do Genetics!!🧬 🪱
Thank you to my lab, especially my co-mentors @DanStarrUCDavis @gwgl1979 , people did great contributions to this work @HongyanHao @DanielElnatan, our collaborator @LiamHoltLab
Also big thanks to CGC for worm resources @cgc_worms and organizers for putting this together @GeneticsGSA , and our funding resources @AllenInstitute @NIGMS
