Nick & I & two eduWOSMs are in India helping out with the Bangalore Microscopy Course 17th. ~25 PhD students get a full-on 8 days of intensive training in light microscopy, from the basics to the latest systems, taught by experts. These joyous scenes are from Jennie Ross's talk.

 Out now on BiorXiv, doi.org/10.1101/2024.08.10.6… is about the eduWOSM, our advanced optical microscope for educational and resource-limited settings. $9K build cost, compact, open source, super-stable, super-bright, super-controllable, user friendly, easy-to-love, able to do this:

Sumiyoshi et al. pubmed.ncbi.nlm.nih.gov/3901… asks, can kinesin heads tethered via surface loops still drive microtubule gliding? Indeed! Scanning a dsDNA tether across all exposed loops reveals a core mechanical cycle of the motor that underlies, and is amplified by, linker docking.

Today Sir Paul Nurse visited us, invited & hosted by students from Warwick's Integrated Science Society. Paul's talk "What is Life?" concluded with the thought that every living thing is connected to its ancestors through an unbroken chain of cell divisions.

Yean Ming's new paper rdcu.be/dmiem shows that different human tubulin isotypes respond differently to taxol. 10 µM taxol accelerates kinesin-driven gliding of α1β4 microtubules, but not α1β3 microtubules. GMPCPP accelerates both.

Yean Ming's now-published paper rdcu.be/dmiem shows that different human tubulin isotypes respond differently to taxol. In these kymographs of segmented isotype microtubules, α1β3 segments depolymerise ~4x faster than α1β4. 100 nM taxol amplifies the difference to ~20x.

A year in a minute - MSci Integrated Natural Sciences warwick.ac.uk/fac/sci/med/st… at Warwick.

Iva Tolic’s provocative work on the forces developed between spindle microtubules has its roots in her early fascination with tensegrity structures - here the beautiful needle tower II en.wikipedia.org/wiki/Kennet…

We are seeking a fellow molecular motors enthusiast. A postdoctoral fellow molecular motors enthusiast atsv7.wcn.co.uk/search_engin…

eduWOSMogenesis, emergent self-replication of eduWOSMs. Note the characteristic bright colouration even at this early developmental stage, enabling these young individuals to clearly distinguish one another even in dense crowds.

Yean Ming’s new work biorxiv.org/cgi/content/shor… shows that taxol acts differently on different human tubulin isotypes. Here, taxol is shifting β4 but not β3 MTs to a faster-gliding conformation, forcing the trailing β4 segments of these gliding β3/β4 MTs to meander.

Integrated Natural Sciences end of term 1 Course Breakfast 2022. Students & course thriving, but more importantly, which gingerbread house is, in fact, the best? Happy Hols to science enthusiasts everywhere!

Molloy meets eduWOSM! The amazing frenzy of actomyosin-driven intracellular transport in a peeled-out layer of onion cells. Field around 230 µm laterally.

This evening Jan Löwe, Director of the MRC Laboratory of Molecular Biology in Cambridge, visits our Integrated Science student society warwicksu.com/venues-events/… to speak about his scientific life, especially it's early stages. All welcome! 18:00-19:30 IBRB 1.01

Thrice welcome from all at CMCB towers to our two newest mechanochemicalcellbiological PI recruits, Justin Molloy and @seamus_holden!