Dynamic Protein Designer @UWproteindesign
Seattle, Washington
Joined April 2017
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We sought to make proteins both potent and FAST. We used #proteindesign to design precise control over protein interaction lifetimes, enabling us to construct rapid-response circuits, biosensors, and switchable cytokines. Now published @Nature! Links to paper and tutorial below.
See this thread for a more technical summary of our findings. xitter.cf/adam_broerman/status/1…
Excited to announce our new #proteindesign strategy for allosterically controlling the kinetics of protein-protein interactions! Read on for cool applications in cytokine signaling, biosensing, and protein circuits. biorxiv.org/content/10.1101/…
Collaborating with @FloPraetorius, @malichtenstein, Christoph @PiehlerLab, @YangZhao102 and @MasatoOgishi at Garcia Lab, Maxx and Mark with @StollPatrol, Harry @DMZuckermanLab, the IPD cores, and all of @UWproteindesign took this project to the next level—thanks to all of you!