@adhynamic

Our lab tries to grasp the molecular mechanisms by which cells adhere to and move through the body environment in cancer, vascular and rare genetic diseases

 Candiolo Cancer Institute, IT
irccs.org/cell-adhesion-dynamics
Joined March 2013
  • Tweets695
  • Following813
  • Followers1.6K
23Media
Glad to share our last manuscript on a luminescent sensor we created to unveil novel potentially actionable regulators of β1 integrin activation in vascular endothelial cells and angiogenesis. Great collab w/ Jieqing Zhu Lab @VersitiResearch @ZanivanLab doi.org/10.1016/j.celrep.202…
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Mechanobiological mechanism of cyclic stretch-induced cell columnarization dlvr.it/TKdwss

Mechanobiological mechanism of cyclic stretch-induced cell columnarization

Lee et al. find that cyclic stretch induces epithelial cell columnarization via Piezo1-dependent mechanotransduction, involving apical cytoskeletal remodeling, tight junction straightening, and...

cell.com
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Local weakening of cell-extracellular matrix adhesion triggers basal epithelial tissue folding Andrea Valencia-Expósito, María Martín-Bermudo et al embopress.org/doi/full/10.10…
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Serini Lab retweeted
Ben Goult@bengoult3 Sep 2024
September issue of @JCellBiol also contains our new paper on TLNRD1 (talin rod domain containing 1) protein and its role in the Cerebral Cavernous Malformation complex. rupress.org/jcb/article/223/… @guijacquemet @LivUniISMIB @biokent @UniTurku – at Liverpool, England

TLNRD1 is a CCM complex component and regulates endothelial barrier integrity

Ball and Ghimire et al. identified that the actin-bundling protein TLNRD1 is an integral component of the CCM complex, specifically binding to CCM2. The TL

rupress.org
Journal of Cell Biology@JCellBiol2 Sep 2024
Our September issue is out! hubs.la/Q02N4zdK0 🔬 The cover shows the heart (cardiac tube) of a 20-day old adult #Drosophila stained with phalloidin (red), while adjacent pericardial cells are marked by dorothy-GFP (green). From @gera_jayati et al (hubs.la/Q02N4zxk0)
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Our paper is now out!! Great and exciting collaborative work. Thank you all. PlexinB1 Inactivation Reprograms Immune Cells in the Tumor Microenvironment, Inhibiting Breast Cancer Growth and Metastatic Dissemination aacrjournals.org/cancerimmun…

PlexinB1 Inactivation Reprograms Immune Cells in the Tumor Microenvironment, Inhibiting Breast...

The authors show that PLXNB1 inhibition in the TME reprograms immune cells and vessels in TNBC models hampering tumor growth and metastasis, and enhancing the response to immunotherapy. Thus, PLXNB1...

aacrjournals.org
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Serini Lab retweeted
Ben Goult@bengoult18 Jun 2024
We just updated our preprint, "The structure of an Amyloid Precursor Protein/talin complex indicates a mechanical basis of Alzheimer's Disease" to include beautiful new proximity ligation data of talin and APP in neurons. 😍 @jcl_lambert @LivUniISMIB biorxiv.org/content/10.1101/… – at Liverpool, England
Talin and Amyloid Precursor protein interaction in neurons, as shown using a Proximity Ligation Assay (aka PLA)

ALT Talin and Amyloid Precursor protein interaction in neurons, as shown using a Proximity Ligation Assay (aka PLA)

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Serini Lab retweeted
Cell@CellCellPress20 May 2024
Now online! Ligand binding initiates single-molecule integrin conformational activation dlvr.it/T791P4

Ligand binding initiates single-molecule integrin conformational activation

Viewing integrins in action through single molecules shows that ligand-dependent activation is the predominant factor initiating signaling.

cell.com
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Rab7 deficiency induces lysosome formation from recycling endosomes leading to an increased degradation of cell surface proteins biorxiv.org/content/10.1101/…

Rab7 deficiency induces lysosome formation from recycling endosomes leading to an increased...

Cell surface receptors such as integrins are repeatedly internalized from and recycled back to the plasma membrane before routed to lysosomes for degradation. In search for modulators of β1 integrin...

biorxiv.org
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Check out our latest review in which we discuss the recent exciting discoveries on single-cell and collective ERK signaling dynamics!
PertzLab@PertzL15 May 2024
Check out our recent review on the ever-evolving #MAPK/#ERK signaling dynamics. It never ceases to amaze me how one of the most studied signaling pathways continues to deliver new surprises. Thanks to @paoloarmando83 for writing this with me. sciencedirect.com/science/ar…
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Very pleased to share our latest preprint on MAPK dynamics and cell fate decisions in lung cancer biorxiv.org/content/10.1101/… . Does EGFR mutation mean MAPK is always on? NO, it shows dramatic pulses👇1/4
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💥Check out our latest work just out @NatureComms 🔬#Platelets shape the outgrowth of #metastasis, even growing & established foci. 🎯We further identified #targets and tools with therapeutic potential rdcu.be/dHL7i #mouse #zebrafish #imaging #Immunology #hemostasis
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Thrilled to announce our latest research just published in @NatureComms! We investigated how therapy induces therapy resistance via cell state transition and vessel co-option in glioblastoma. (1/11) nature.com/articles/s41467-0… #GBM #btsm #Research

VC-resist glioblastoma cell state: vessel co-option as a key driver of chemoradiation resistance

Nature Communications - In patient with glioblastoma, a major cause of resistance to chemotherapy and radiotherapy is the high degree to intratumoral heterogeneity and cell plasticity. Here, the...

nature.com
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Our latest paper! A promising avenue for therapeutic intervention in fibroses, characterized by excessive ECM production, via targeted inhibition of TANGO1-mediated ER export. TANGO1 inhibitors reduce collagen secretion and limit tissue scarring nature.com/articles/s41467-0…
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Thrilled to see our latest work “Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function” led by Alice Santi and @emilyjkay1 on the cover of @scisignal. Beautiful images by @BairBeatson Paper here 👇🏻 science.org/doi/10.1126/scis…
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Serini Lab retweeted
Guido Serini@gserini18 Jul 2023
Looking very much forward to my visit to @CIBIO_UniTrento of Thu July 20th, meeting and discussing with its scientists
CIBIO - UniTrento@CIBIO_UniTrento18 Jul 2023
We are glad to host "In search of normality: looking for molecular strategies to repair #cancer blood vessels" a seminar by @gserini 🗓️ July, 20th at 2.30pm 🏛️ Room A104, Povo 1 ℹ️ webmagazine.unitn.it/node/11… #blood #bloodtumor
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We are glad to host "In search of normality: looking for molecular strategies to repair #cancer blood vessels" a seminar by @gserini 🗓️ July, 20th at 2.30pm 🏛️ Room A104, Povo 1 ℹ️ webmagazine.unitn.it/node/11… #blood #bloodtumor
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Interested in a Post-doc @IvaskaLab @BioscienceTurku working on novel anti-invasive barriers in BrCa - cutting edge cell biology/imaging/HTS/clinical collaboration? Watch this space! We will be shortly opening a call a post-doc @WorldwideCancer granted 3 year funding
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Online today! 👉Mutated #AxonGuidance gene #PLXNB2 sustains growth and invasiveness of stem cells isolated from #CancerOfUnknownPrimary By @GiraudoEnrico, L. Tamagnone & colleagues @fpoirccs @unito @Unicatt 🗞️Read #openaccess: doi.org/10.15252/emmm.202216…
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Our paper is now out!! Great and exciting collaborative work. Thank you all. xitter.cf/EmboMolMed/status/1620…
EMBO Mol. Medicine@EmboMolMed1 Feb 2023
Online today! 👉Mutated #AxonGuidance gene #PLXNB2 sustains growth and invasiveness of stem cells isolated from #CancerOfUnknownPrimary By @GiraudoEnrico, L. Tamagnone & colleagues @fpoirccs @unito @Unicatt 🗞️Read #openaccess: doi.org/10.15252/emmm.202216…
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Serini Lab retweeted
Polo Lab@polosimona123 Jan 2023
Latest preprint from our lab: a myosin VI-Dock7 axis controls RAC1 in follower cells to promote collective motion!! Great collaboration with @scita_lab @IFOM and Fabio Giavazzi @confucio_unimi biorxiv.org/cgi/content/shor…
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