@agtebo

🏳️‍🌈🧬🔬 fluorescent biosensors, protein engineering, Group Leader @HHMIJanelia, Black Lives Matter, she/they

janelia.org/lab/tebo-lab
Joined March 2009
  • Tweets501
  • Following355
  • Followers965
6Media
We’re excited to announce the next Fluorescent Proteins & Biological Sensors conference! Abstract submissions are now open—hope to see you there. janelia.org/you-janelia/conf…

Fluorescent Proteins and Biological Sensors VIII

janelia.org
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Alison Tebo retweeted
Polly Fordyce@fordycelabJun 3
Characterizing AI-designed proteins requires quantitative biochemistry at massive scale. Enter Amplicon/Protein Bead Display (APB-Display), a fully in vitro platform that quantifies Kd's for >100,000 variants in <3 days (preprint link below!) @Stanford_ChEMH @czbiohub (1/n)
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We're excited to announce that plasmids for HYlight2, our improved sensor for fructose 1,6-bisphosphate, are now available on @Addgene! Preprint is here: biorxiv.org/content/10.64898…
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📢 Applications are open! Join us @HHMIJanelia to explore next-gen fluorescent proteins, biosensors, imaging advances + ML/computational approaches to accelerate design. 🛏️ Meals & lodging covered Apply by May 21 ➡️ janelia.news/FPS26 @HHMIscience @ERSchreiter @agtebo
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👩🏽‍🔬Do your graduate research at Janelia! ✨ Apply by Dec. 1 to our joint graduate programs with @JohnsHopkins & @HopkinsMedicine. 🥼 Experience the benefits of training in a highly collaborative & innovative research environment. Learn more & apply ➡️ janelia.link/graduate-progra…
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🥼The Tebo Lab @HHMIJanelia develops high-performance biosensors for bioimaging using new protein engineering techniques. But did you know that protein engineering also enhances laundry detergents? Learn more at #ScienceOnTap on Oct. 17 @OldOxBrewery. Hosted by @LoudounLibrary.
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NPR’s @NPRjonhamilton did a podcast on @FlyWireNews #connectome and our simulation work, comparing it a bit to fly immortality. Have a listen, it’s fun. Or come hear about it today at #sfn2024 Dual Perspectives session at 1.30pm. npr.org/2024/10/07/121093585…

Fruit flies are hard to swat. Mapping their brain might tell us why : Short Wave

Fruit fly brains are smaller than a poppy seed, but that doesn't mean they aren't complex. For the first time, researchers have published a complete diagram of 50 million connections in an adult...

npr.org
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We recently posted a preprint from my lab, summarizing work over the past couple of years where we show that the neuromodulator dopamine is released from varicosities that synapse onto the processes of target neurons. biorxiv.org/content/10.1101/…

Synaptic Specializations at Dopamine Release Sites Orchestrate Efficient and Precise Neuromodulat...

Dopamine is a key chemical neuromodulator that plays vital roles in various brain functions. Traditionally, neuromodulators like dopamine are believed to be released in a diffuse manner and are not...

biorxiv.org
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🔊 Listen to Janelia Group Leader @srinituraga & @uni_tue Professor @jakhmack discuss their new research using AI & the connectome to predict brain cell activity on NPR's All Things Considered!🎙️ hhmi.news/3TnvOQU

A new AI model can predict some brain signals in fruit flies

Researchers have created an AI model that can predict some fruit fly brain signals. It was able to predict the activity of neurons in a fruit fly by looking at how those neurons were connected.

npr.org
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the lab is recruiting scientists @HHMIJanelia! we are particularly excited about engineering fluorescent proteins and biosensors using high-throughput assays and machine learning. questions? please get in touch!
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The Kilosort4 paper is now published @naturemethods. We put a lot of work into building and properly documenting all things Kilosort (including for older versions). w/ @computingnature #kilosort paper: nature.com/articles/s41592-0… code: github.com/MouseLand/Kilosor…
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#Cellpose remains the state-of-the-art for cellular segmentation. See our new paper, in response to Ma et al, Nat Methods 2024. Paper: biorxiv.org/content/10.1101/… Leaderboard results ⬇️⬇️⬇️
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#Cellpose 3! Not all images are perfect. Restore your images with Cellpose3 to get better segmentations, w/ @marius10p biorxiv.org/content/10.1101/…
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Alison Tebo retweeted
Pratik Kumar@prat_i_k14 Jan 2024
Turns out rhodanine-based fluorogen can be combined with spliFAST tags to dimerize proteins :-) New work with Tebo lab @agtebo and twitter-less Alina @HHMIJanelia biorxiv.org/content/10.1101/…

Transforming chemigenetic bimolecular fluorescence complementation systems into chemical dimerizers...

Chemigenetic tags are versatile labels for fluorescence microscopy that combine some of the advantages of genetically encoded tags with small molecule fluorophores. The Fluorescence Activating and...

biorxiv.org
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Alison Tebo retweeted
CC_Lab@chiluncellbio30 Nov 2023
We are thrilled to introduce FABCON, a “Fluorogen-Activated Bimolecular complementation at CONtact sites” tool kit for interrogating lipid droplet-organelle interaction and beyond in living cells. biorxiv.org/content/10.1101/…

A fluorogenic complementation tool kit for interrogating lipid droplet-organelle interaction

Contact sites between lipid droplets and other organelles are essential for cellular lipid and energy homeostasis. Detection of these contact sites at nanometer scale over time in living cells is...

biorxiv.org
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Transgenic Tet- and Cre-inducible jGCaMP8m/s mice lines are now available as pre-order from JAX.  Janelia is distributing a new RiboL1-tagged line that localizes jGCaMP8s to the soma.  Check out the white paper describing all the lines and order here: forms.gle/jnmBfZdh8g7QVRBg7
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For the past decade, Luke Lavis (@rhodamine110) and his team have been creating and perfecting the Janelia Fluor dyes. Now, they’re working with biologists to design dyes for specific biological applications. janelia.org/news/next-genera…

Next-generation Janelia Fluor dyes do more than just shine

To neuroscientist Jason Vevea, Luke Lavis is not just a chemist. He’s a modern-day magician. For the past decade, Lavis, a senior group leader and head of Janelia’s molecular tools and imaging

janelia.org
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🔥 Apply now for Beyond the Connectome, a conference examining the development of tools & techniques for acquiring, storing & utilizing additional data types to increase the impact of current & future connectomes.🧠 Apply by June 16 ➡️ janelia.org/you-janelia/conf… @janeliaconf
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🔬 Are you an imaging expert looking for your next challenge? 🔥 Apply today for one of our open positions or check out our open call for imaging experts ▶️ hhmi.news/3nxXPIo
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📢 Applications are now open for the seventh installment of our Fluorescent Proteins and Biological Sensors conference, showcasing the development of cutting-edge tools & technology for biological imaging. Learn more and apply by June 9 ➡️janelia.org/you-janelia/conf… @janeliaconf
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