Open access science and drug discovery. Founded and (still) direct @thesgconline. My comms folks shudder when I tweet.
Toronto
Joined October 2010
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aled edwards retweeted
A well anticipated overview highlighting the first CACHE challenge, which brought together 23 research teams from 10 countries to collectively predict 1,955 compounds targeting LRRK2-a protein linked to #ParkinsonsDisease.
pubs.acs.org/doi/10.1021/acs…
aled edwards retweeted
A news feature by @Nature addresses the longstanding issue of unreliable antibodies in biomedical research and highlights the efforts of initiatives like @YCharOS1.
A piece worth reading featuring the amazing work by @laflamme_c58627's group: nature.com/articles/d41586-0…
aled edwards retweeted
Save the date for the second annual Conscience Symposium on Open Drug Discovery! Join us in Montreal on April 7-8, 2025, for two days dedicated to advancing open and AI-driven drug discovery. Learn more: conscience.ca/event/save-the…
This WD paper reports machine learning applied to DNA-encoded library screening datasets at scale. Bottom line it works. Sometimes. Lots of opportunities to improve. Including by open sourcing models as James has done here.
chemrxiv.org/engage/chemrxiv…
In collaboration with @XChemInc, @Relay_Tx, & @Google we published a large-scale effort to unlock the potential of WD40 proteins-cloning 100, screening for ligands, & making vast resources publicly available.
pubs.acs.org/doi/10.1021/acs…
The Unites States government is now going to do the grand experiment to test if those loud and opinionated armchair athletes and coaches have what it takes when given the chance to lead the team. I don’t think it’s going to be pretty.
Waiting to board flight to Toronto and just in front of me in line was @FP_Champagne, Canada’s Minister of Industry and other things. He headed to his seat in economy (as did I). Spending Canadian tax dollars wisely. Gotta like it.
Want to be a fly on the wall in an industry-standard drug discovery program? Join the M4K Pharma monthly zooms. Real pros at work, sharing their expertise to try to invent an open source medicine to treat children’s brain tumours.
M4K Pharma's October Scientific Update meeting is now available online: youtube.com/watch?v=c5-4CZQC…
In this session, our team provides detailed insights into the latest progress on developing new treatments for DIPG through our #OpenScience approach.
#BrainCancer #Medicines4Kids
aled edwards retweeted
#AlphaFold3 is open-source for academic use now! See what our partner, @MoAlQuraishi, has to say about our upcoming OpenFold3 project and commercial availability. #BioAI #OpenSource #OpenFold
nature.com/articles/d41586-0…
aled edwards retweeted
Just Launched! Episode 1 of the Target 2035 Podcast Series🎧 In the debut episode, @LabScribbles welcomes @CherylArrowsmi1, a leading scientist in chemical biology and one of the initiators of Target 2035.
podcasters.spotify.com/pod/s…
#Target2035 #OpenScience #DrugDiscovery
It’s very encouraging that funders support projects like YCharOS, which does not address hypotheses, but rather does the foundational, but not sexy, work of testing and characterizing reagent antibodies in order to make everyone else’s science more robust and reproducible.
CQDM is proud to announce the funding of a collaborative research project made possible through a grant of nearly Can$1.49M from the Government of Quebec (@economie_quebec). A project of @YCharOS1 in partnership with @mcgillu.
👉cqdm.org/en/news-and-events/…
Congrats to @thesgconline Board member, Dafydd Owen 🏴, for leading the team that invented the active ingredient in Paxlovid, which was awarded a #PrixGalien prize last night!
Trump got fewer total votes this election than last. 12 million (!!) Democrats just didn’t show up and vote this time. It would have been landslide Harris victory if they had.
aled edwards retweeted
Steve Kerr on the election
Kerr: “I believe in democracy. I think the American people have spoken and voted for Trump. I want him to do well the next four years. I want our country to do well.”
Kerr (sarcastically): “I'm just thankful there wasn't any voting fraud this time. Last time, all those illegal immigrants who crashed the border, raped and murdered people and then voted six times, that was unfortunate. But thankfully this time everything was clean. It's great that every election has been really valid except for that last one four years ago. Twinkle in my eye as I say that, in case you didn't see it.”
Listen to his full answer below 👇🏼
🎥: @NoaDalzell
aled edwards retweeted
Draining the swamp. Assessment of 614 commercial antibodies, targeting a total of 65 neuroscience-related proteins, demonstrated two thirds of them did not work as recommended by manufacturers. Don’t trust, validate @aledmedwards nature.com/articles/d41586-0…
aled edwards retweeted
Neuroscientist Carl Laflamme describes @YCharOS1, an initiative testing commercial antibodies to determine if they work as advertised, and making findings open to improve research efficiency and reproducibility. via @Nature
buff.ly/40AgsNn
#OpenScience
A charismatic leader. Economic malaise. Enemies within. Expert propaganda. Angry young men. Demonization of “others”. And voted into power. We’ve seen this script before. C’mon America, we don’t want to watch the sequel.
Does machine learning work on DEL datasets? Indeed it does. Sometimes.
pubs.acs.org/doi/10.1021/acs…