@alperlab

Molecular and Cellular Biophysics Laboratory

 Clemson, SC
alperlab.sites.clemson.edu/
Joined August 2015
  • Tweets134
  • Following273
  • Followers195
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Check out or latest paper on dynein regulation in trypanosomes. Outstanding work, @subashcgodar et al! journals.plos.org/plospathog… @EPICClemson @ClemsonScience @ClemsonResearch @PandaClemson

Light chain 2 is a Tctex-type related axonemal dynein light chain that regulates directional...

Author summary Kinetoplastea is a class of ciliated protists that include parasitic trypanosomes, which cause severe disease in people and livestock in tropical regions across the globe. All trypan...

journals.plos.org
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Beautiful work! Conversion of anterograde into retrograde trains is an intrinsic property of intraflagellar transport cell.com/current-biology/ful…

Conversion of anterograde into retrograde trains is an intrinsic property of intraflagellar...

Intraflagellar transport (IFT) allows the assembly of cilia by moving components from the cell to the ciliary tip and back. Nievergelt et al. demonstrate that, contrary to what was previously...

cell.com
If you are in DC stop by the National Museum of American History and the #ACCelerateFestival to learn about our lab's Building Brains project! @ClemsonResearch @ClemsonScience @PandaClemson
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Our latest paper is now available online at Biophysica Journal! Long-Range Electrostatic Interactions Significantly Modulate the Affinity of Dynein for Microtubules disq.us/t/46bnirk @ashoknizamian17 @ClemsonScience @PandaClemson @apurbapaul0 @ClemsonResearch
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Good luck, Pauline! It's awesome to see former Alper Lab members do such great things!
Clemson University
@ClemsonUniv9 Feb 2022
Tune in to watch Pauline Bisaccio, a junior in Biochemistry and Psychology, represent Clemson during the #JeopardyCollegeChampionship Thursday night at 8/7c on ABC and Hulu! 🏆 We asked Pauline questions about her experience! ⤵️
A woman wearing an orange shirt with Clemson across the front stands behind a Jeopardy podium.

ALT A woman wearing an orange shirt with Clemson across the front stands behind a Jeopardy podium.

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Read our latest paper: Calculating the force-dependent unbinding rate of biological macromolecular bonds from force-ramp optical… disq.us/t/446uwpl. Congratulations @apurbapaul0! @PandaClemson @ClemsonScience @ClemsonResearch
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If you or someone you know is looking for a great summer undergraduate research experience, check out the Biophysics REU at Clemson - clemson.edu/science/departme…
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Our latest pre-print is available: Long-Range Electrostatic Interactions Significantly Modulate the Affinity of Dynein for Microtubules biorxiv.org/content/10.1101/… Congratulations Ashok! @ashoknizamian17 @PandaClemson @ClemsonScience

Long-Range Electrostatic Interactions Significantly Modulate the Affinity of Dynein for Microtubules

The dynein family of microtubule minus-end directed motor proteins drives diverse functions in eukaryotic cells, including cell division, intracellular transport, and flagellar beating. Motor protein...

biorxiv.org
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Alper Laboratory retweeted
bioRxiv@biorxivpreprint25 Nov 2021
Long-Range Electrostatic Interactions Significantly Modulate the Affinity of Dynein for Microtubules biorxiv.org/cgi/content/shor… #bioRxiv
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Our latest pre-print is now available - Light chain 2 is a Tctex-type related axonemal dynein light chain that regulates directional ciliary motility in Trypanosoma brucei biorxiv.org/content/10.1101/… Nice work, Subash et al.! @subashcgodar @PandaClemson @ClemsonScience

Light chain 2 is a Tctex-type related axonemal dynein light chain that regulates directional...

Flagellar motility is essential for the cell morphology, viability, and virulence of pathogenic kinetoplastids, including trypanosomes. Trypanosoma brucei flagella exhibit a bending wave that...

biorxiv.org
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Check out our latest pre-print: Calculating the force-dependent unbinding rate of biological macromolecular bonds from the force-ramp optical trapping assays biorxiv.org/content/10.1101/… Nice work, Apurba! @apurbapaul0 @PandaClemson @ClemsonScience

Calculating the force-dependent unbinding rate of biological macromolecular bonds from the force-...

The non-covalent biological bonds that constitute protein-protein or protein-ligand interactions play crucial roles in many cellular functions, including mitosis, motility, and cell-cell adhesion....

biorxiv.org
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Check out our latest paper - Out-of-Equilibrium Biophysical Chemistry: The Case for Multidimensional, Integrated Single-Molecule Approaches pubs.acs.org/doi/10.1021/acs… Congratulations Ashok et al! @ashoknizamian17 @ClemsonScience @PandaClemson

Out-of-Equilibrium Biophysical Chemistry: The Case for Multidimensional, Integrated Single-Molecule...

Abstract. Out-of-equilibrium processes are ubiquitous across living organisms and all structural hierarchies of life. At the molecular scale, out-of-equili

pubs.acs.org
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Check out our latest preprint on the TPP riboswitch in RNA! Great work @subashcgodar! rnajournal.cshlp.org/cgi/con…
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Check out our latest preprint: Ensemble Switching Unveils a Kinetic Rheostat Mechanism of the Eukaryotic Thiamine Pyrophosphate Riboswitch disq.us/t/3vi4ptc
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Undergrads looking for a great summer opportunity: Biophysics REU program - Nature’s machinery through the prism of physics, biology, chemistry and engineering jobs.spsnational.org/jobs/14…
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BPS and the Motility & Cytoskeleton Subgroup are pleased to congratulate Marija Zanic, Vanderbilt University, recipient of the Subgroup's 2021 Early Career Award! @ZanicLab @VUBasicSciences
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Alper Laboratory retweeted
New Scientist
@newscientist25 Jul 2020
Rosalind Franklin, born 100 years ago today, made a significant contribution to the discovery of the DNA double helix, but was overlooked for a Nobel prize. bit.ly/32Pg6o7
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Congratulations Hailey et al.! @HaileyDLovelace
Dimitris Vavylonis@DVavylonis24 Jul 2020
Our contribution to "Symmetry Breaking in Cells and Tissues” Cells issue: Spatial model of pombe Cdc42 oscillations, with past and current group members, including REU student @HaileyDLovelace : mdpi.com/778122

Fission Yeast Polarization: Modeling Cdc42 Oscillations, Symmetry Breaking, and Zones of Activation...

Cells polarize for growth, motion, or mating through regulation of membrane-bound small GTPases between active GTP-bound and inactive GDP-bound forms. Activators (GEFs, GTP exchange factors) and...

mdpi.com
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I will add a statement to my syllabus that requires students to have a socially-distanced, absolutely required in-person meeting with the instructor both on the first and last day of the semester. It is worth 1% of the final grade and is non-negotiable. ice.gov/news/releases/sevp-m…
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Here is our new lab poster and our commitment. Thanks to @SammyKatta for the idea and templates. More here: sammykatta.com/diversity
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