Alternative splicing on alternative music. PI at @CompHealthMuc & CCRC Hauner (LMU) Previously: Postdoc - @landau_lab; PhD - @Koenig_lab
Munich, Germany
Joined February 2012
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I'm happy to share that since January, I have started my lab at @HelmholtzMunich @CompHealthMuc
& Hauner CCRC (LMU) 🎉
We aim to combine single-cell, long-reads, computational modeling, and functional genomics to understand RNA-driven regulation in pediatric diseases.
Mariela Cortés López retweeted
nature.com/articles/s41375-0…
Cancer is an RNA disease: DNA is not destiny, RNA determines leukemia fate
Mariela Cortés López retweeted
Check out full text here: cell.com/cell/fulltext/S0092…
Congrats to Wei-Yu, Sang-Ho, @raimondi_ivan and the whole team! Grateful to @TheMarkFdn @SMaHTnetwork @cegs_ica for the support
Mariela Cortés López retweeted
🚨Paper alert🚨 Very excited to share our manuscript, published today in @ImmunityCP, where we describe how ‘Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome’. (1/16) cell.com/immunity/fulltext/S…
Mariela Cortés López retweeted
We have an open position for a #PhD student (last week to apply!) & a lab technician/TA. For more information see: beuschlab.org/join-us
Interested in understanding post-transcriptional regulation and how #RNA #splicing decisions are made? Then take a look or share with others!
I am currently recruiting PhD students, both computational and experimental jobs.helmholtz-muenchen.de/q… and jobs.helmholtz-muenchen.de/u… Feel free to reach out or share with anyone interested.
Mariela Cortés López retweeted
Huge shoutout and congrats to Chiara Evans (@pharmphreshsci) & Hanzhi Luo (@hanzhi_luo)! 🎉
Two @KharasLab oral presentations TODAY at #ASH25:
🕧 12:30 W224 —MSI2 arginine methylation HSC and therapy
🕒 3:15 W311 — Blood stem cells & nuclear speckles with SON
Don’t miss them!
Mariela Cortés López retweeted
Today, postdoc leaders from across campus met to determine next steps for winning a fair contract. We voiced our support for countering @WeillCornell's arbitrary deadline with OUR OWN strike deadline to ensure they make real progress by the end of the month. Stay tuned!
Mariela Cortés López retweeted
#OnlineFirst In the Spotlight: RNA Splicing as a Therapeutic Vulnerability in Therapy-Refractory #MultipleMyeloma doi.org/10.1158/2643-3230.BC…
A commentary to Therapy-Resistant Subpopulation in Myeloma doi.org/10.1158/2643-3230.BC…
Mariela Cortés López retweeted
Interested in learning how to be a good speaker and give effective talks? Season 2 of the NYC Postdoc Night Science Club begins October 15th. Join us NYC Postdocs for a 2hr workshop and maybe also a drink at a bar! Free registration (usually ~100 come): docs.google.com/forms/d/1dII…
Mariela Cortés López retweeted
Today hundreds of us came out to our Picket to Protect Science to show @WeillCornell that they must agree to a fair contract now!
Mariela Cortés López retweeted
Hi, we've made a new R package for APA analysis of long read RNA-Seq data. Works best on Oxford Nanopore direct RNA-Seq data. We call it APALORD. apalord.com
Mariela Cortés López retweeted
Delighted to have our preprint led by @lvchosen1 up: Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells
biorxiv.org/content/10.1101/…
🧵 below ...
Mariela Cortés López retweeted
The cells in our bodies constantly acquire mutations. But what are the patterns of mutations across tissues? How do mutations in normal cells lead to disease? These and other questions we will tackle within the SMaHT Network, now described in @Nature
nature.com/articles/s41586-0…
Sharing this op-ed we co-authored with other international postdocs, highlighting the struggle of doing science under an increasingly hostile political climate, while also fighting for fairer working conditions.
“We moved across the world to do life-saving research. We deserve stability, not uncertainty. We will strike if necessary for protection and a fair contract”
medium.com/@alt_spliced/inte…
Mariela Cortés López retweeted
Very excited to share our new paper out now in @MolecularCell. We show how U1 snRNP -a well-known splicing factor- regulates the activity of alternative promoters in human cells cell.com/molecular-cell/full…
Mariela Cortés López retweeted
[1/n]📢How is your spatial analysis *transcript*-omic if transcripts are only aggregated to gene counts? Introducing SPLISOSM, our new computational method for learning the isoform landscape and its regulation from spatial transcriptomics data
doi.org/10.1101/2025.05.02.6…
Mariela Cortés López retweeted
"Single-molecule multimodal timing of in vivo mRNA synthesis" a collaboration with Rippei Hayashi's lab, work led by AJ Sethi @_AJSethi #RNA #premRNA #splicing #RNAprocessing #m6A #polyadenylation biorxiv.org/content/10.1101/…
Mariela Cortés López retweeted
🚨Today in @CellCellPress, we show that RNA splicing factor mutations in myeloid cancers generate splicing-derived public neoantigens targetable by #TCR tx. Amazing collaboration co-led by @AbdelWahablab, @bradleybio, and @KlebanoffLab. #Tcellpower
cell.com/cell/fulltext/S0092…
