Annie Ly (@anni3_ly) header
Annie Ly (@anni3_ly) profile picture

Annie Ly

@anni3_ly

PhD candidate @NeuronRoot lab | NIMH F31 NRSA Fellow | Former postbac @HurdLab | @Middlebury '16 | she/her

 Boulder, CO
scholar.google.com/citations?user=qIf9keEAAAAJ&hl=en
Joined January 2019
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4Media
Photo by Annie Ly (@anni3_ly)Photo by Annie Ly (@anni3_ly)Photo by Annie Ly (@anni3_ly)Photo by Annie Ly (@anni3_ly)
🤩🔥👏 Amazing story from ⁦@NedergaardLab⁩ on what drives brain clearance during sleep || Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep: Cell cell.com/cell/fulltext/S0092…
Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep

Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep

Norepinephrine oscillations during NREM sleep drive synchronized changes in cerebral blood volume and cerebrospinal fluid, promoting glymphatic clearance. Optogenetic and pharmacological manipulati...

cell.com
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Different information sharing mechanisms shaping different social foraging dynamics , check out and share our new preprint : biorxiv.org/content/10.1101/…
Image from Ahmed El Hady (@zamakany)
Ahmed El Hady (@zamakany) profile pictureAhmed El Hady
@zamakany4 Dec 2024
Replying to @zamakany
and also live on biorXiv, make sure to share it around : biorxiv.org/content/10.1101/…
Social patch foraging theory in an egalitarian group

Social patch foraging theory in an egalitarian group

Foraging is a widespread behavior, and being part of a group may bring several benefits compared to solitary foraging, such as collective pooling of information and reducing environmental uncertain...

biorxiv.org
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I'm excited to share with you all our new paper (co-authors the twitterless Anna Lally and @Healeylab) out in @CommsBio!! I've made a tweet thread abstract below, spooky halloween style.🎃 Open access at the following link: doi.org/10.1038/s42003-024-0… 1/14
Auditory pallial regulation of the social behavior network

Auditory pallial regulation of the social behavior network

Communications Biology - A study in songbirds using site-directed pharmacology, immediate early gene labeling, and awake electrophysiology reveals a link between regions of the pallium critical for...

nature.com
Jeremy Spool (@jeremyspool) profile pictureJeremy Spool@jeremyspool9 Mar 2023
New preprint with twitterless Anna Lally and @HealeyLab ! 📰doi.org/10.1101/2023.03.08.5… Mystery! Intrigue! Auditory pallium! Social behavioral control? Birds?? Brains?! 1/2
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It's peak spooky season- but imagine not feeling any fear at all! This week, @PennNGG student Omer Zeliger discusses Patient S.M., a woman with a rare neurological disorder that quite literally made her fearless. Learn more here: pennneuroknow.com/2024/10/29… #scicomm #spookyscience
Patient S.M.: Neuroscience’s most fearless participant

Patient S.M.: Neuroscience’s most fearless participant

From creepy-crawlies to horror films, S.M. takes them all in stride. For almost 35 years, she has been helping neuroscientists understand why.

pennneuroknow.com
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A little article I wrote about our research and queer women's health research broadly: OPINION Queer women are overlooked in LGBTQ+ and women’s health research, and we’re here to change that  windycitytimes.com/2024/10/2…
OPINION Queer women are overlooked in LGBTQ+ and women’s health research, and we’re here to change...

OPINION Queer women are overlooked in LGBTQ+ and women’s health research, and we’re here to change...

By Cindy Veldhuis  NOTE: This article focuses primarily on research and health among cisgender queer women, largely because I am a cisgender queer woman myself, and this perspective has shaped my...

windycitytimes.com
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Ever wanted to explore the driving forces underlying inhibitory neuronal signalling? We did! So, for my MSc in @JosephRaimondo lab, we developed the all-optical approach ORCHID - all-Optical Reporting of CHloride Ion Driving force. Now out in @NatureComms nature.com/articles/s41467-0…
Image from Josh Selfe (@joshsselfe)
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26 years after Larry Swanson emphasized “the amygdala is neither a structural or functional unit” we used sn-RNAseq to answer the question: “What is the [primate] amygdala?” Check out the preprint 👇 biorxiv.org/content/10.1101/…
Image from Vincent Costa (@VincentCostaPhd)
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Neuroscientists care about the causes of behavior, while ethologists care about the consequences. These approaches need to merge for us to understand human behavior and its associated suffering. Dorian Battivelli, Fan Zhengxiao, Hu Hailan, and I lay out the why and what.
EMBL Rome (@EMBLRome) profile pictureEMBL Rome@EMBLRome15 Oct 2024
The study of behavior requires a combination of the ethology and neuroscience approaches. The latest publication from the Gross group outlines the tools needed to optimise this holistic approach to study fear, aggression and dominance behaviours: nature.com/articles/s41583-0…
Image from EMBL Rome (@EMBLRome)
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Shoutout to @_TheTransmitter for some excellent recent articles! Highly recommend these recent pieces: thetransmitter.org/the-big-p… And this one on what defines a neural mechanism (a key topic we cover in my first-year PhD systems neuroscience class): thetransmitter.org/the-big-p…
What makes memories last—dynamic ensembles or static synapses?

What makes memories last—dynamic ensembles or static synapses?

Teasing out how different subfields conceptualize central terms might help move this long-standing debate forward. I asked eight scientists to weigh in.

thetransmitter.org
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A new tool for visualising synaptic vesicle release sites: A Munc13-1-SNAP knock-in mouse line. It works with the help of a new chemical biology probe, by the one and only @BroichhagenJ biorxiv.org/content/10.1101/…
Endogenous tagging of Munc13-1 with a SNAP tag as a tool for monitoring synapse nanoarchitecture

Endogenous tagging of Munc13-1 with a SNAP tag as a tool for monitoring synapse nanoarchitecture

Synaptic function is governed by highly regulated protein machineries, whose abundance and spatial localization change continually. Studies to determine the dynamic changes in synaptic proteins...

biorxiv.org
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New preprint from @kuldeepshrivas3 looking at how BNST and lateral hypothalamic glutamatergic neurons coordinate reward seeking based on energy state. researchsquare.com/article/r…

Energy state guides reward seeking via an extended amygdala to lateral hypothalamus pathway

Impaired regulation of food intake underlies numerous health problems, including obesity and type 2 diabetes, yet how brain systems controlling reward seeking become dysregulated to promote overeat...

researchsquare.com
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Big news! The fly connectome is featured on the cover of a special edition of Nature. This is all possible thanks to the collaboration of 292 members of The FlyWire Consortium! nature.com/immersive/d42859-… Check out the thread for an overview of the 9 #flywire papers published today
Image from FlyWire (@FlyWireNews)
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The brain has a surge in functional connectivity moments before death: pnas.org/doi/abs/10.1073/pna…
Surge of neurophysiological coupling and connectivity of gamma oscillations in the dying human...

Surge of neurophysiological coupling and connectivity of gamma oscillations in the dying human...

The brain is assumed to be hypoactive during cardiac arrest. However, animal models of cardiac and respiratory arrest demonstrate a surge of gamma ...

pnas.org
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One week from today, the Nobel Prize in Medicine/Physiology will be announced. Here are the 79 most likely awardees, each of whom has won two or more pre-Nobel “predictor” prizes:
Image from Jason Sheltzer (@JSheltzer)
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We're thrilled to share the lab's first preprint- on CRF neurons, hypocretin/orexin signaling, and BNST neurophysiology in excess alcohol drinking and withdrawal-enhanced anxiety behavior! A collaborative effort with @JulieKauer75377 and @AnneVassalli, led by postdoc Dr. Yihe Ma
Image from Giardino Laboratory (@GiardinoLab)
bioRxiv Neuroscience (@biorxiv_neursci) profile picturebioRxiv Neuroscience@biorxiv_neursci8 Sep 2024
Sex-Specific Roles of Hypocretin Receptor Signaling in CRF Neurons on Alcohol Drinking, Anxiety, and BNST Neuronal Excitability biorxiv.org/cgi/content/shor… #biorxiv_neursci
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We are hiring 3+ Neuroscience faculty at CU Boulder! Seeking applicants with outstanding research programs in cell/molecular neuroscience, behavioral neuroscience, and integrative physiology. #academicjobs @FuturePI_Slack @NeuroRumblr jobs.colorado.edu/jobs/JobDe…
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big day!! so excited to share the preprint of my postdoc project in @TheHongLab 🥳🥳🙌🏼🙌🏼🕺🏼🕺🏼 we identified how prefrontal populations enable social groups to coordinate into huddles during thermal challenge! ❄️🐭🐭🐭🐭❄️
bioRxiv Neuroscience (@biorxiv_neursci) profile picturebioRxiv Neuroscience@biorxiv_neursci19 Sep 2024
Neural basis of collective social behavior during environmental challenge biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Excited to share the preprint of my thesis work in @themazelab! In collaboration with @MuirLab we utilized a new chemical tool to label and enrich for endogenous substrates of protein dopaminylation in vivo! my favorite bits below:🧵 biorxiv.org/content/10.1101/…
Hippocampal γCaMKII dopaminylation promotes synaptic-to-nuclear signaling and memory formation

Hippocampal γCaMKII dopaminylation promotes synaptic-to-nuclear signaling and memory formation

Protein monoaminylation is a class of posttranslational modification (PTM) that contributes to transcription, physiology and behavior. While recent analyses have focused on histones as critical...

biorxiv.org
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Effect of psilocybin versus escitalopram on depression symptom severity in patients with moderate-to-severe major depressive disorder: observational 6-month follow-up of a phase 2, double-blind, randomised, controlled trial - eClinicalMedicine thelancet.com/journals/eclin…

Effect of psilocybin versus escitalopram on depression symptom severity in patients with moderate...

Six-week intensive treatments with either psilocybin or escitalopram (with psychological support) for MDD were associated with long-term improvements in depressive symptom severity. The greater...

thelancet.com
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Motion capture technology sheds light on how flocks of pigeons detect and respond to predator attacks while foraging for food. elifesciences.org/digests/95…

Vigilant pigeons

Motion capture technology sheds light on how flocks of pigeons detect and respond to predator attacks while foraging for food.

elifesciences.org
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