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Many of you have been asking us: "Who is Approved?" "Where is Approved?" and even, sometimes… "Why is Approved?"
Rather than let this mystery haunt us any longer, here is our official breakdown of what this podcast covers. Check it out:
Approved retweeted
Biotech still runs on who owns the patent and who approves the drug.
That was my takeaway from @alexkesin's session at DataDrivenPharma West last week.
Alex wrote one of the most widely shared analyses of China's biotech rise this year, and it has become a reference point in the policy debate. He also co-hosts @approvedfm with [@MatthewPech], a podcast on how drugs get discovered, developed and sold. He walked a room of operators through where the value sits now.
Four quick hits:
- 1:3. Doing the work in China costs a half to a third of the US price.
- Rent, don't sell. Beijing's new export controls block the sale of biotech platforms. Licensing, partnerships and contract research stay open.
- 3x. China tripled its university patent conversion rate in two years, to 10.1%.
- 8% to 32%. China's share of the global early-stage pipeline, from 2015 to 2024.
The first hit explains the last five years. China got cheap and fast, and the West bought what it built. Most of those deals were fast-follows on targets Western labs discovered. The West owned the original IP and rented China's speed.
The other three point to the next five.
The export controls dropped the same morning as the session. Read them next to the new five-year plan, which makes biotech and biomanufacturing a national priority through 2030. The strategy looks clear to me. Generate IP faster than the US, keep ownership at home, and let the world license it.
Pipeline share has quadrupled. Patents are moving out of universities and into companies. Nine out of ten still sit unused, so there's plenty of room to grow.
Patents are still the currency. Regulators still set the exchange rate. The FDA turned away a Chinese PD-1 copycat because its trial ran only on Chinese patients. To get paid in the US, you still need FDA approval and a partner who can launch here.
What changes is who holds the paper. When the West generated the IP, licensing meant Western companies owned the value and paid for speed. As more IP is generated and kept in China, the same deal structure sends more value the other way. The West ends up renting the molecule instead of owning it.
This is a gold rush for intellectual property. The question is who can generate novel IP in a specific area, and do it first.
Therapeutics is the beachhead. The US market pays enough for new drugs that the long road through the FDA still earns a return.
In this gold rush, anyone can be a miner. The fastest ones will have the best maps.
And maps only come from data.
#ddpwest26
Approved retweeted
An absolute masterpiece of a podcast episode by @approvedfm @alexkesin and Matthew Pech about Blueprint Medicines. As someone who worked in a platform company for 16 years I found myself in rapt attention. I now also know what a CVR is. :-)
open.spotify.com/episode/4Z0…
Approved retweeted
I encourage folks to listen to the episode about Geron on @approvedfm - directly relevant here re what it takes to take a stem cell therapy to clinic and then to approval.
Induced pluripotent stem cell technology has already opened countless new possibilities for treating disease, but Shinya Yamanaka says he believes the best is yet to come.
cell.com/stem-cell-reports/f…
Approved retweeted
.@alexkesin and Matthew Pech have an absolute masterpiece of a podcast about the science and business of getting a medicine to approval: @approvedfm
Every episode is like a superb thriller movie. I cannot recommend it strongly enough.
podcasts.apple.com/us/podcas…
Approved retweeted
Apparently @approvedfm is now among the top 200 science podcasts on Apple Podcasts. A very pleasant surprise indeed!
Approved retweeted
This podcast is great! Like Acquired, but for biotech/pharma. Couple great episodes already!
Approved retweeted
If you haven’t already please subscribe and listen to @approvedfm . It’s such an excellent podcast.
Approved retweeted
How did Botox go from an obscure treatment for lazy eye to a wrinkle drug?
The answer may surprise you: a single perceptive patient!
Approved retweeted
One (of so many) highlights of this great ep of Approved=focus on von Hippel concept of "Field Discovery"-how many new indications (here, for Botox, but true more generally-classic ref, from 2006, is this: pubmed.ncbi.nlm.nih.gov/1650… ) originated w observant clinicians. @alexkesin
Wow-another fantastic ep of "Approved" pcast w @alexkesin & Matthew Pech, this time focused on improbable story of botox, from bioweapon to strabismus med (1st indic!) to med for aesthetic & other uses: podcasts.apple.com/us/podcas… (2y ago I rev'd fascinating bk on topic for WSJ)
Approved retweeted
Wow-another fantastic ep of "Approved" pcast w @alexkesin & Matthew Pech, this time focused on improbable story of botox, from bioweapon to strabismus med (1st indic!) to med for aesthetic & other uses: podcasts.apple.com/us/podcas… (2y ago I rev'd fascinating bk on topic for WSJ)
Approved retweeted
Even outside of pharma, Botox is one of the world's strangest enduring businesses.
The total amount of drug sold globally each year weighs about *two ladybugs* by mass; its biggest commercial moat runs on manufacturing secrets; and most famously, its biggest use case (cosmetics) was discovered by accident.
So it's no wonder then that it's been fought over as much as it has (we get into that!)
New on @approvedfm: the history of Botox and the company that made it, Allergan Pharmaceuticals.
Approved retweeted
I'm biased but this is such a cool listen on the complexity and fun of drug discovery.
Both Christoph and Alexis (2 of my Curie.Bio co-founders), plus a few other members of our team, talking about how they built Blueprint Medicines into a $9.5b M&A deal with a real meaningful approved medicine for patients.
approved.fm/p/blueprint-medi…
podcasts.apple.com/us/podcas…
Approved retweeted
Huge kudos to @alexkesin and Matthew Pech for yet another captivating episode of Approved, this one about Blueprint Medicine & early days of @ThirdRockV podcasts.apple.com/us/podcas… - really captures nuance, messiness, uncertainty, & gap between narrative & life so well!
Approved retweeted
Blueprint Medicines went from having under $100k in the bank to a $9.1B acquisition last year by Sanofi. All thanks to a "holy grail" kinase platform and a lucky pivot into mast cell disease.
New @approvedfm + exclusive interviews with the founders and drug hunters, out now:
RT @alexkesin: Our next episode of Approved dives into Blueprint Medicines.
Out on Tuesday, August 4th.
Approved retweeted
Finally got around to listening to the @approvedfm keytruda episode and I recommend it. It strikes the difficult balance between science and narrative. Lots of original material including interviews with Organon and Schering-Plough execs. More of this please.

















