Cheyenne (@booleanbio) header
Cheyenne (@booleanbio) profile picture

Cheyenne

@booleanbio

Working at the intersection of AI and drug development. Just here to bool sh*t ✨

ceziegler.com
Joined September 2022
  • Tweets534
  • Following423
  • Followers290
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Photo by Cheyenne (@booleanbio)Photo by Cheyenne (@booleanbio)Photo by Cheyenne (@booleanbio)Photo by Cheyenne (@booleanbio)Photo by Cheyenne (@booleanbio)Photo by Cheyenne (@booleanbio)Photo by Cheyenne (@booleanbio)Photo by Cheyenne (@booleanbio)Photo by Cheyenne (@booleanbio)
Cancer patients with the same diagnosis often have very different tumor biology. Molecular testing can reveal underlying differences, but that's slow and expensive. Introducing Holon-S1, our platform to predict genes and biomarkers from routine pathology slides. • beats two other models at predicting spatial gene activity in a controlled comparison • has identified potentially novel biomarkers in breast cancer and colon cancer • evaluated across 16 organ types and more than 15 scanners, using slides from both formalin-fixed, paraffin-embedded and fresh-frozen tissue. We believe Holon-S1 has the potential to help researchers find new biomarkers in slides they already have, discover treatment targets, and bring more personalized cancer care within reach!
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Cheyenne retweeted
JT (@jiratickets) profile picture
JT
@jiraticketsOct 19
Next year, I will assign one of my jira tickets to every kid in America. This will be the first of many.
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A look inside Origin Genomics and our work to advance therapeutic germline gene editing, from NPR. npr.org/2026/09/29/nx-s1-595…
This startup wants to prove gene-editing embryos is safe for making healthy babies

This startup wants to prove gene-editing embryos is safe for making healthy babies

Origin Genomics aims to prove that the potential benefits of its technology for editing disease-causing genes in human embryos outweigh the risks.

npr.org
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at ucsf
Image from Kevin A. Scott, PhD (@Sculpturatus)
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Cathy Tie (@CathyTie) profile picture
Cathy Tie
@CathyTieAug 21
Every day we get closer to a world where people can be born without inherited disease
Image from Cathy Tie (@CathyTie)
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Avi Marcus (@Avi_Marcus) profile picture
Avi Marcus
@Avi_MarcusJun 28
Image from Avi Marcus (@Avi_Marcus)
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Bio red-teaming group called mCherry
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I interviewed @geochurch and learnt we're already gene editing humans. You just haven't noticed. 0:00 - Gene Editing Mammals → Humans 8:36 - Germline vs Somatic 14:56 - Modified Humans Are Already Here 18:50 - Enhancing Healthy Humans 25:00 - Aging Therapies vs Cognitive Enhancement 30:20 - Embryo Selection 38:10 - Is US Losing To UAE? 42:33 - Biotech Failures 49:31 - Next Dire Wolf Moment 54:21 - AI x Science 1:02:07 - Synthetizing Entire Genomes
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Jake Feala (@FealaJake) profile picture
Jake Feala
@FealaJakeFeb 22
I drink alcohol sometimes, but only for the dropout regularization
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Will (@wstone_bd) profile picture
Will
@wstone_bd26 Dec 2025
Image from Will (@wstone_bd)
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Wow! This is so cool and way more fun than boring BioRender! Plus, developing fine motor skills through hand drawing and creativity without limitations in shapes or form! Try it out yourself here chat.figurelabs.ai/invitatio…
Image from PiatkevichLab (@PiatkevichL)
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🚨🧬 Want to build in drug discovery? Join the M-Boltz Hackathon (Oct 20–21, 2025) with @merckgroup & the awesome Boltz team! Tackle challenges in protein, nucleic acid & drug co-folding, scale cutting-edge models, and build the next wave of open science. (+ get to hang with @GabriCorso) 🌍 Hubs in Darmstadt & Boston + remote 💡 Sponsored by @huggingface, @nvidia , and @awscloud 🔗 Register now: moml.mit.edu/m-boltz-hackath…
Image from Georgia Channing (@cgeorgiaw)
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Replying to @SynBio1
Only real biologists own this pen.
Image from Cheyenne (@booleanbio)
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send me a message, i take a nap call that a rest api
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MLSB @workshopmlsb will be a co-located event with NeurIPS this year! Despite the workshop proposal being rejected, the community loves MLSB so much - we’re excited to keep this going with all your support! (Pls help spread the word that MLSB is still happening)
Gina El Nesr (@ginaelnesr) profile pictureGina El Nesr
@ginaelnesr28 Jul 2025
The MLSB workshop will be in San Diego, CA (co-located with NeurIPS) this year for its 6th edition in December 🧬🔬 Stay tuned @workshopmlsb as we share details about the stellar lineup of speakers, the official call for papers, and other announcements!🌟
Image from Gina El Nesr (@ginaelnesr)
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🚀 GenMol is now open‑sourced: you can now train and finetune on your data! It uses masked diffusion + a fragment library to craft valid SAFE molecules, from de novo design to lead optimization. #GenMol #DrugDiscovery #Biopharma
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Guy who just woke up at noon: "We are so early"
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reviving this meme once again.
Image from ℏεsam (@Hesamation)
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25 years
Image from David M. Sabatini (@DMSabatini)
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Last bit of rant for the night (insomnia sucks): Humans make things. It's your birthright as a human to be free to make things and be at the helm of your own destiny. Anything that reduces agency in exchange for convenience is an act of misanthropy emboldened by greed.
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