Single cell biology, cancer genomics, mathematical methods. Associate Professor at @PennGenetics

Philadelphia, PA
Joined October 2011
New preprint from our lab🎉: "Morphology-robust quantification of subcellular organization in complex cells", led by Robert Hu, in collaboration with @ophirshalem and Nima Naseri. biorxiv.org/content/10.64898…
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Pablo G. Camara retweeted
Happy to share the revised and now published in Cell Systems version of our paper, where we explore why dCas9-KRAB(KOX1) protein levels drop so drastically after neuronal differentiation in WTC11 and KOL2.1J iPSC lines. Paper: doi.org/10.1016/j.cels.2026.…
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Pablo G. Camara retweeted
Big progress vs cancer, folks. The kind of event curves from randomized trials that we've not seen before for a couple of the most deadly cancers. Congrats to the oncology research community for getting these trial done. #ASCO26, @ASCO
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Pablo G. Camara retweeted
Our CytoSignal paper is now published in @NatureGenet! During revision, we generated a one-of-a-kind dataset with direct measurements of ligand-receptor protein interactions in situ in the mouse embryo, along with Visium HD spatial transcriptomics. nature.com/articles/s41588-0…
How can you use RNA velocity to infer the dynamics of cell signaling from spatial transcriptomic data? Check out our new preprint!
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Pablo G. Camara retweeted
🤩 spatial panoramic in vivo CRISPR screen via Perturb-DBiT 🤩 Excited to share our collaborative work with @sidichen lab and many outstanding collaborators, now published in Nature Biotechnology! nature.com/articles/s41587-0…
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We’d love to hear from people who try it, especially on datasets where cell morphology has made localization analysis difficult.
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We are really grateful to @czi and the @NIH BRAIN Initiative for supporting this effort.
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Pablo G. Camara retweeted
I think @littmath makes a good point. Erdos' quote aside, mathematicians are not machines to prove theorems, nor is human society or economy a machine to optimize anything else than what humans decide is valuable, and we need humans to do so.
Assuming models have complete advantage over human mathematicians in all areas of math (IMO not guaranteed in 15 years, but likely enough), this seems to be a question about the shape of society. Arguably the answer is not at all special to math--presumably the answer is basically the same for all knowledge work (and maybe all professions?). I think in this world the most likely background situation is that humans are not really useful for proving theorems, but nonetheless lots of basic and understandable questions remain open, including many that are open today (since I think these have basically unbounded difficulty). And lots of other questions of basic interest have been resolved. So human activities might include (1) trying to understand solutions, (2) trying to understand progress and obstructions to resolving open questions, (3) (non-rigorously) understanding mathematical phenomena. In all these activities, the purpose of the human is to serve as a locus of understanding. There's an obvious question as to why we would pay someone to do this. One plausible answer is that maybe we want to avoid complete disempowerment--at a minimum we might want people to understand what they can about what the AIs are doing--which requires development of human capital.
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Pablo G. Camara retweeted
Multiple post-doctoral positions are available in my group!

 Human Statistical Genomics Population Genomics Complex traits studies (diabetes, cardiometabolic traits) Data science and methods development projects See voightlab.com/join for details.
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Pablo G. Camara retweeted
As we are sending back the revised version of our pooled prime editing gene tagging paper, I am happy to share a website for design of prime tagging libraries, including some images, all generated from a single pooled transduction and in situ sequencing. primetagging.org
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