Neuroscience Postdoc & Paediatrician. Researching the Autism-Epilepsy co-occurrence + other brain things. Aspiring to be a clinical academic.
London, England
Joined November 2015
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Delighted to have our work published in @ImagingNeurosci
🤔 TLDR:
We studied the activity of communicating neural populations. Our findings:
- Provide new insight into the nature of this communication
- Inform how M/EEG functional connectivity should be measured
New paper in Imaging Neuroscience by Chirag Mehra, Jonathan O’Muircheartaigh, et al:
Zero-phase-delay synchrony between interacting neural populations: implications for functional connectivity-derived biomarkers
doi.org/10.1162/IMAG.a.985
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Including zero-phase connectivity increased the reliability, convergence with neurobiology and prognostic ability of functional connectivity metrics.
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🎯 Why it matters:
Our findings present a shift to how the field should consider and handle zero-phase-delay functional connectivity.
Many thanks to @ahmadbeyh, @JonnyOMuir, and many others in @Aims2Trials.
Have a read, and tell me your thoughts!
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🧠Preprint Alert!
We show the first evidence that EEG brain-connectivity measures can predict changes in adaptive functioning (skills applied to navigate the everyday environment) in #autistic people.
📄Full text: doi.org/10.1101/2025.05.17.2…
#EEG #Neuro #Biomarker
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The metrics worked best for autistic people aged 15-21 years – a key transitional period of development.
⚡️The EEG measures:
✅ Outperformed behavioural predictors of adaptive function
✅ Showed high test-retest reliability
✅ Were associated with brain-volume genes
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Chirag Mehra retweeted
Zero-phase-delay connectivity increases the reliability, concordance with structure, and prognostic ability of functional ... biorxiv.org/cgi/content/shor… #biorxiv_neursci
Chirag Mehra retweeted
📢 We are excited to announce that the Handbook of Diffusion MR Tractography is finally out! 🎉
Huge thanks to all the authors and the ever growing tractography community at IST @tractography and DSG-ISMRM @DiffusionISMRM !!
From @flaviodellacqua, @maxdescoteaux, @Alex_Leemans
🎉 New Year, New Preprint.
Happy to share the first preprint from my #PhD! 🧠
🤔 TL;DR: Our findings are relevant to anyone using EEG/MEG functional connectivity analyses. They affect the choice of method when analysing data.
Check it out : shorturl.at/TD3wc
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📊 Findings:
Using a novel approach, we found that most FC occurs with zero-phase-delay, even when artefactual connectivity is likely negligible. Including zero-phase connectivity increased the reliability, convergence with neurobiology and prognostic ability of FC metrics.
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Our findings present a shift to how the field should consider and handle zero-phase-delay functional connectivity. Have a read and let me know your thoughts!
#Neuroscience #Neuroimaging #EEG #brainconnectivity
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We just need one more participant to complete the @Aims2Trials LEAP-Epilepsy study 🎉
If you have co-occurring #autism and #epilepsy, are aged between 6-35 years and live in the UK, please consider participating in our study!
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This is one of the most important things happening in academia right now. Thanks @LucinaUddin, this is amazing.
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