em retweeted
Replying to @NondescriptRed
A lot of people who talk about opsec don't have operations to secure and should probably focus on job security first
Another pompous bumblefuck who needs to shut up and grow up. Counterculture this counterculture that. Just another smug little sanctimonious sycophant you are. Don't you know that the motto of this city is "Oro en Paz, Fierro en Guerra" - Gold in Peace, Iron in War? This city was sticks before the gold rush of 1849, literal sticks, population 1,000. Why the hell do you think this city exists in the first place? Gold diggers, literal gold diggers, that's right. What the hell do you think came before the hippies? You think Yerba Buena has been populated with beatniks since time immemorial? Get fucking real. Picks and shovels, jostling elbows, that's the true spirit of San Francisco. Look at our flag. A phoenix - boom and bust, baby, boom and bust. You don't know jack you fucking softie. I'm sure you love aping as a cultural connoisseur. Who the fuck do you think funded the Symphony, the Opera? Stanford is railroad money. Hearst is mining money. Who the fuck do you think saved the Opera last year? Jensen Huang - AI money. Just kidding, you don't go to any of those places cuz you ain't even from here, you fucking East Coaster! You don't know diddly-squat about San Francisco, I bet you call it San Fran! Shut the fuck up about our city. All you know is tourist shit. You know why we have cable cars? Because we fucking invented them in 1873. You know why we're the only city to still have cable cars in 2026? Cuz we have the highest fucking GDP per capita on the planet. "min-maxed Machiavellian social dynamics" Shut the fuck up! It's another boom cycle and we're doing what we do best, which is inventing the future and making money doing it. Name the last time NYC invented a new technology and scaled it to the gigawatt. Yeah, you fucking can't. Why don't you go back to your bodega and have a little chopped cheese? Fucking poser.
It has been interesting to watch San Francisco as it has been stripped of nearly all of its original countercultural garments (distrust/apathy towards The Cathedral, high-openness, suspicion of credentialism, original thought, etc.) and has donned a new zeitgeist that is the absolute antithesis of its former ethos.
Everywhere you look resembles third-world, low-trust, social hierarchy jostling . "How much did you raise bro? Did you get the Sequoia check? You don't work at a Tier 1 lab? You didn't... didn't go to Stanford?".
The city that was once great because of its disgust with these sorts of people has now been corrupted by them as they have min-maxed Machiavellian social dynamics to accumulate power in the valley like XP points. Power which is now completely divorced from any genuine talent, skill, or benevolence. All that matters is that you are able to Scam a16z out of $15M (@cluely) because you are a poaster and you are anointed with SF Clout™
This infestation is so deep that even those who rightfully call it out are still willful participants in the exact culture they so detest (check her bio).
em retweeted
dude "you can see everything" was so boring, i couldn't even make it an hour and a half into the movie before i left the theater
em retweeted
some news: i didn't get the job at anthropic :/
i did well at the technicals but they were disappointed that i was unable to commit to inhaling a pack of unfiltered mongolian cigarettes during the interview, citing a lack of confidence that i truly believed in transformative asi
Replying to @viriditax
literally 0 understanding of cerebrolysin or prions
a successful synthesis of a 'EC508', an estradiol prodrug with a slower release, that could provide oral HRT pills much less damaging to the liver. pretty cool!
update on this (short 🧵)
initial synthesis has succeeded with a good yield!
some time within the next month or so i’ll be publishing the second part of this which will go into the pharmacology of EC508, which will be more interesting than an alternate synthesis route.



























