@corcoran_lab

Dr. Jenn Corcoran (she/her) Interested in what viruses have to teach us about cell biology. FIND ME NOW AT: @corcoranlab.bsky.social

 University of Calgary, Canada
Joined July 2015
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  • Following1.1K
  • Followers1.4K
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Thrilled to share our most recent paper. Led by the amazing @marielkleer, we show that a viral RNA called kaposin drives nuclear speckle seeding beside the KSHV viral genome, an event which optimizes viral gene expression. sciencedirect.com/science/ar…
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ShorterLab@ShorterLabOct 24
PARP1 directly disassembles nucleosomes to regulate DNA repair: Molecular Cell cell.com/molecular-cell/full… – at Millbourne, PA

PARP1 directly disassembles nucleosomes to regulate DNA repair

Verma, Zhu, et al. show that PARP1 promotes NAD+-dependent eviction of H2A-H2B dimers, generating oriented hexasomes with increased DNA accessibility. The H2A C-terminal tail supports this remodeling...

cell.com
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BAK and BAX form a multiprotein complex to drive mtDNA efflux and caspase-independent cell death | Science science.org/doi/10.1126/scie…

BAK and BAX form a multiprotein complex to drive mtDNA efflux and caspase-independent cell death

The apoptotic regulators BAX and BAK, once activated, form homo-oligomers to trigger mitochondrial outer membrane permeabilization (MOMP), activating the apoptosome and caspases. Activation of...

science.org
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Silvi Rouskin
@silvirouskinSep 26
This is totally brain shattering ;) An LLM that was never “told” what is thermodynamics, was just given sequences , picks up alternative structures of riboswitches and critical tertiary loop-loop contacts. It also discovers new putative human riboswitches ( stay tuned :). Shout out to God of RiNAlmo @msikic Check out our updated pre print biorxiv.org/content/10.64898…
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Ryan Hisner@LongDesertTrainSep 26
Phenomenal 🧵 (& paper) on why Omicron is less efficient at infecting lungs than previous variants. Initial ideas on this were proven wrong, & it's been an utter mystery since. Stuart has largely explained it & revealed vital aspects of the SARS-2 life cycle along the way.
Stuart Turville@StuartTurvilleSep 25
SARS-CoV-2 phenotypic trajectory and the Omicron Paradox. Discussion of the following pre-print and the complex intertwined pathways that have dictated phenotypic outcomes for SARS-CoV-2. This can be otherwise termed the pandemic to endemic trajectory: biorxiv.org/content/10.64898…

Proteolytic control of the SARS-CoV-2 furin cleavage site defines the phenotypic evolution from the...

The successive emergence of SARS-CoV-2 variants with altered tissue tropism has progressively decoupled transmissibility from lower respiratory tract pathogenicity. Omicron lineages transmit except...

biorxiv.org
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ShorterLab@ShorterLabSep 23
Direct cell-to-cell transmission of retrotransposons: cell.com/cell/fulltext/S0092…

Direct cell-to-cell transmission of retrotransposons

Retrotransposons can infect neighboring cells using a mechanism that relies on a small fusogen-like protein rather than on the envelope protein that is typically required for infection.

cell.com
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Eric Topol
@EricTopolSep 22
How do cells die? What used to be thought were 2 ways, now it's >20 nature.com/articles/d41586-0…
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Corcoran Lab@corcoran_labSep 17
Nuclear body assembly by a viral repeat RNA promotes Kaposi’s sarcoma-associated herpesvirus gene expression: Molecular Cell cell.com/molecular-cell/full…

Nuclear body assembly by a viral repeat RNA promotes Kaposi’s sarcoma-associated herpesvirus gene...

Kaposin is an abundant viral RNA produced by the virus, Kaposi’s sarcoma-associated herpesvirus (KSHV). Kleer et al. reveal that kaposin drives nuclear speckle formation adjacent to the viral genome,...

cell.com
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Snyder Spotlight: Meet the Lahl Lab! What happens to a baby’s immune system as it develops? The Lahl Lab is working to better understand the complex processes that shape immune development early in life. #SnyderInstitute #UCalgary #Research #Immunology #SnyderSpotlight
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Nuclear body assembly by a viral repeat RNA promotes Kaposi’s sarcoma-associated herpesvirus gene expression: Molecular Cell cell.com/molecular-cell/full…

Nuclear body assembly by a viral repeat RNA promotes Kaposi’s sarcoma-associated herpesvirus gene...

Kaposin is an abundant viral RNA produced by the virus, Kaposi’s sarcoma-associated herpesvirus (KSHV). Kleer et al. reveal that kaposin drives nuclear speckle formation adjacent to the viral genome,...

cell.com
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A new/old SARS-CoV-2 paper for us is now in @NatureComms nature.com/articles/s41467-0… We submitted first in 2023 and due to a variety of reasons, it is now out, in 2026. The manuscript details our look into conserved SARS-CoV-2 Omicron mutations outside the receptor binding domain.

Loss-of-function mutation in Omicron variants reduces spike protein expression and attenuates...

Nature Communications - Spike mutations in SARS-CoV-2 Omicron variants impact vaccine-mediated protection. In this study, the authors identify mutations that also alter spike cleavage and virus...

nature.com
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Molecular Cell@MolecularCellSep 16
Online Now: Nuclear body assembly by a viral repeat RNA promotes Kaposi’s sarcoma-associated herpesvirus gene expression dlvr.it/TVWFm2
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Mini-Medical School Lecture Series Season 12! Hear from Dr. Fui Boon Kai and Dr. Kerri Johannson as they explore the biology behind fibrosis and how the disease progresses and the challenges. Learn more and register: snyder.ucalgary.ca/series-tw… #MiniMedicalSchool #PulmonaryFibrosis
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ShorterLab@ShorterLabSep 16
Nuclear body assembly by a viral repeat RNA promotes Kaposi’s sarcoma-associated herpesvirus gene expression: cell.com/molecular-cell/full…

Nuclear body assembly by a viral repeat RNA promotes Kaposi’s sarcoma-associated herpesvirus gene...

Kaposin is an abundant viral RNA produced by the virus, Kaposi’s sarcoma-associated herpesvirus (KSHV). Kleer et al. reveal that kaposin drives nuclear speckle formation adjacent to the viral genome,...

cell.com
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@MIID_UCalgary @Charb_Cancer @UCalgaryMed @SnyderInstitute
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Thanks also to essential contributions by co-authors @rorypmulloy Maxwell Bui-Marinos, Michael Johnston, Morgan Khan and David Schriemer.
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ShorterLab@ShorterLabSep 8
Strenuous physical activity is associated with a younger age of amyotrophic lateral sclerosis onset in two independent cohorts: academic.oup.com/braincomms/…

Strenuous physical activity is associated with a younger age of amyotrophic lateral sclerosis onset...

Kennedy et al. report that strenuous exercise may contribute to an earlier onset of amyotrophic lateral sclerosis in susceptible individuals. Within two co

academic.oup.com
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Incredibly happy to share the first publication from our lab, now published in Nature Cell Biology! 🎉 How do cells coordinate RNA processing with nuclear organization and the cell cycle? nature.com/articles/s41556-0… 1/10
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