Jake Smith (@crying_EM) header
Jake Smith (@crying_EM) profile picture

Jake Smith

@crying_EM

doing some science | using cryo-ET to study tissues in situ ❄️🔬 | @OxCellStruBio @RosFrankInst

Joined October 2019
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cryo lift out: a summary
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it was great to share some results from mine & @glynnca93's latest preprint! It has been an interesting meeting with plenty of overlap between different imaging modalities/sample prep disciplines. Lots of insightful discussion/ideas!🔬 @VolumeEM1
Rosalind Franklin Institute (@RosFrankInst) profile pictureRosalind Franklin Institute@RosFrankInst22 Oct 2024
Jake Smith (@crying_EM), PhD student at the Franklin and @UniofOxford , gave a fascinating talk this afternoon about his PhD work studying the hippocampus using cryo-EM as part of the vEM Technology Forum's Cryo FIB-SEM Methods Development Session. #vEMTechForum2024 @VolumeEM1
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cool tie @ the bear
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After thousands of microscope hours and several years of painstaking optimisation, @glynnca93 and I are very excited to share our latest manuscript. We outline our approach to investigate the molecular organisation within hippocampus tissue using cryo-ET.
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We hope that our structural and cell biology friends can adapt our approach to their favourite tissue biology question. To find out more, please check out our preprint: biorxiv.org/content/10.1101/… #teamtomo #LiftLaughLove
Charting the molecular landscape of neuronal organisation within the hippocampus using cryo...

Charting the molecular landscape of neuronal organisation within the hippocampus using cryo...

Cellular cryo-electron tomography (cryoET) enables the capture of detailed structural information within a biologically relevant environment. However, information in more complex samples, such as...

biorxiv.org
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A huge shoutout to the rest of the team at the Franklin for making this happen. And of course the biggest shoutout to Michael Grange (now twitter-less) for steering the ship🫡. On to the next one 👀🧠🔬
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15 years later nothing has changed...
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watching the 3DEM mailing list:
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Subtomogram averaging from lamellae
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Our high-resolution (2.2 Å) in situ structural work reveals details of translational landscape, with various cofactors and antitumor drug/inhibitor, all directly within human cells! biorxiv.org/cgi/content/shor…
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big well done @hels_watson & team! obligatory group meeting slide to commemorate such an occasion hopefully you free up the GPUs now this is out
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excited to finally have a copy! @BriegelAriane @FriedrichForst1 (also thanks Magdalen xxx)
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Cars and microscopes
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Hallelujah! He has risen! (jk the autoloader is broken)
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al fresco coffee break whilst getting that bank holiday sun 😍 happy Easter from me and the hydra 💕
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