We uncover how cells sense, communicate, and exchange material, with a focus on pH sensing, intercellular communication, and the dark proteome.
Miami
Joined August 2019
- Tweets509
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IsomLab retweeted
Brain cancers take advantage of neural circuit activity. Re-purposing an anti-seizure med called levetiracetam disrupts an important neuron-cancer interaction in #DMG #DIPG, slowing growth and extending survival in mice and retrospective patient data.
nature.com/articles/s41591-0…
IsomLab retweeted
Happy to share our preprint: "A Unified 3D Generative Model for Synthesizable Structure-Based Drug Design". Highlights, preprint, and code below: 🧵1/10
IsomLab retweeted
67 years ago today, ‘Take Five’ by Dave Brubeck Quartet was released as a single.
It went on to become the best-selling jazz single of the 20th century.
IsomLab retweeted
BindCraft2 from the @MartinPacesa lab is here and available now on Ariax!
We called BindCraft a “DeepSeek moment” in protein design. BC2 builds on that proven foundation with major speed improvements and a much broader range of therapeutic formats.
ariax.bio/resources/bindcraf…
IsomLab retweeted
From the one and only Jacob Rowe. An Editorial Pick which highlights top papers at the greatest @jbiolchem ! Check it out- this is molecular engineering at its best.
PIONEER: A Periplasmic Display Platform for Synthetic Biology-Based Screening of Genetically Encoded Protein Regulators - Journal of Biological Chemistry jbc.org/article/S0021-9258%2…
IsomLab retweeted
We just made an app that walks you through designing a novel protein with AI from scratch. Takes about 5 minutes, requires zero biology knowledge.
➡️ design-a-protein.com
The best part: we will actually synthesize 1000 of those protein designs in the lab and test their real world function as a therapeutic.
IsomLab retweeted
And at @SylvesterCancer @umiamimedicine, Zheng Chen, Alejandro Villarino, Yan Guo, @PeterHoseinMD, & Oliver McDonald will study an enzyme that they believe may drive tumor growth and immune suppression in gastric cancers & could be a therapeutic target.
themarkfoundation.org/portfo…
IsomLab retweeted
The @Pap_Corps continues to make strides toward a world without cancer. Congratulations, Dr. Daniel Isom (@danIsomLab), honored with endowed chair in recognition of his impactful research in molecular and cellular pharmacology. 🙌 loom.ly/UYwl2h4
IsomLab retweeted
Yesterday a Nobel prize was given for alpha fold. Alpha fold could not exist without the Protein Data Bank (PDB), a public database funded by US taxpayers. Every structural biologist in the world that deposited their structure to the PDB indirectly helped train alpha fold.
IsomLab retweeted
#BTS at @SylvesterCancer labs & offices where innovation meets discovery! 🧪🔬 Uncovering the science @TheRaiLab @SWelfordLab @danIsomLab Kerry Burnstein David Lombard Jaime Merchan @MikkaelSekeres that shapes the future, one experiment at a time.
IsomLab retweeted
I’m really excited to see this manuscript finally make it out into the world. It was a lot of fun & taught us more than we thought it would.
jbc.org/article/S0021-9258(2…
IsomLab retweeted
Now that we are settled into our new digs at @FredHutch in Seattle, the Ring Lab is expanding! We have 2 #postdoc positions and a research tech position open. See below for links. (1/4)
IsomLab retweeted
Meet 👋🏽 Sam Taylor, Cancer Biology Grad Student of @danisomlab, working to push the boundaries of molecular & cellular pharmacology. The Tumor Biology Program @sylvestercancer is dedicated to applying cutting-edge technologies to provide leading-edge care for cancer patients.
IsomLab retweeted
.@DrJashDatta, a surgical oncologist at Sylvester, was awarded an $800,000 grant by the U.S. @DeptofDefense for his innovative #research on #PancreaticCancer. Learn more about the study: loom.ly/2nfUpZo
IsomLab retweeted
"PoseBusters: AI-based docking methods fail to generate physically valid poses or generalise to novel sequences"
"We show that no DL-based method yet outperforms standard docking methods when consideration of physical plausibility is taken into account."
arxiv.org/abs/2308.05777
IsomLab retweeted
Marie Curie died of aplastic anaemia on 4 July 1934, a result of years of exposure to radiation through her work. Even today her laboratory notebook from 1899-1902, is radioactive and will be for 1,500 years.
ALT Two pages from Madame Curie's notebook. She has made scientific notes with pictures and handwritten text.
IsomLab retweeted
Proteins with similar sequences would be expected to have similar structures. But sometimes seemingly minor sequence changes can lead to big structural changes.
cen.acs.org/physical-chemist…
IsomLab retweeted
Contrastive learning in protein language space predicts interactions between drugs and protein targets pnas.org/doi/abs/10.1073/pna…
IsomLab retweeted
Registration deadline today! Join us in July for a great conference!
Motifs, modules, networks: Assembly and organization of regulatory signaling systems asbmb.org/meetings-events/mo…
