We study genomics and viral diseases, especially HIV and now feat. COVID-19, and spend a lot of time wondering what makes viruses cause disease.
Madison, WI
Joined June 2015
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Got milk? Interested in citizen science? We are starting to look for grocery store milk and cream from certain dairy processors (can be identified from labeling on the carton) from around Wisconsin as part of our ongoing H5N1 influenza monitoring. DM @dho_lab if interested.
The job will involve working with @publichealthmdc and our clinical colleagues at @UWHealth to examine sequences from people at high risk: persistent infections, reinfections, and those who become infected despite full vaccination.
The job requires lab work and personnel oversight, but could have partial work-from-home options for the right candidate, especially for those who are strong in computational biology. Apply at jobs.hr.wisc.edu/en-us/job/5… by June 21 for assured consideration. CC: @dho @tcfriedrich
New work in collaboration with colleagues at UC-Davis modeling sexual transmission of #Zika virus during early pregnancy. Repeated intravaginal ZIKV challenge was followed by embryonic loss in 2 out of 3 pregnancies. doi.org/10.3389/fimmu.2021.6…
oconnorlab retweeted
Excited to see that this review with my friends from @TheDohertyInst and @KirbyInstitute on SARS-CoV-2 assays and animal models is out! nature.com/articles/s41577-0…
Been a while since we posted new animal model data. In collaboration with @BCM_HGSC we are making a new high quality long-read Syrian golden hamster genome. First results are full-length blood transcripts with data here: ncbi.nlm.nih.gov/bioproject/…
oconnorlab retweeted
Our preprint on initial results of rapid turnaround, mobile RT-LAMP testing now available. Much work to do, but pretty encouraging. medrxiv.org/content/10.1101/… – at MADISON
My group with @slo_wis , @tcflab , regulatory support from @UWMadison, saliva guidance from @NathanGrubaugh , support from @WARF_News , @wnprc, and @NIH RADx.
First day testing van-based, fast-turnaround COVID testing by RT-LAMP. Spit in a tube (h/t @NathanGrubaugh), inactivate for 30 minutes, then RT-LAMP to look for color change. Hoping a version of this could enable twice-weekly testing of teachers to keep schools open.
oconnorlab retweeted
@KATarinambraun and I have been so fortunate to be in labs that allowed us to shift gears and quickly begin to understand the current pandemic! Excited to see where this all goes! @dho_lab @tcflab – at Wisconsin, USA
When SARS-CoV-2 began spreading around the world, graduate students Katarina Braun and Gage Moreno made a quick pivot from studying virus evolution and transmission to sequencing local samples of the virus that causes #COVID19: grad.wisc.edu/2020/06/09/cor…
Introducing the Southwest bike trail virus that we identified in common marmosets. Congrats to Anna for getting it into Biorxiv!biorxiv.org/content/10.1101/…
oconnorlab retweeted
We have updated our WI #SARSCoV2 @nextstrain build to show the 369 genomes that @KATarinambraun and I have sequenced. You can now view it by all of WI, Dane County, or the greater Milwaukee area with higher resolution in the map view ➡️ go.wisc.edu/r7374f
@dho_lab @tcflab
oconnorlab retweeted
Our preliminary analysis of the #Milwaukee #SARSCoV2 / #hCoV19 outbreak is on @LabKey at go.wisc.edu/dp6k0p. The Milwaukee epidemic appears to have few introductions and is largely driven by established chains of local transmission.
@KATarinambraun @dho_lab @tcfriedrich
Certain neighborhoods in #Milwaukee have been disproportionately affected by #COVID19 but lacked viral sequencing to understand their outbreak. @KATarinambraun and I were lucky enough to add 93 sequences to the global tree to begin to understand the #MKE outbreak @dho_lab @tcflab
oconnorlab retweeted
Certain neighborhoods in #Milwaukee have been disproportionately affected by #COVID19 but lacked viral sequencing to understand their outbreak. @KATarinambraun and I were lucky enough to add 93 sequences to the global tree to begin to understand the #MKE outbreak @dho_lab @tcflab – at Wisconsin, USA
We've just added 93 new genomes from Wisconsin to nextstrain.org/ncov thanks to @KATarinambraun @GageKMoreno @tcflab @dho_lab @GISAID! New seqs in red. 37 of these cluster together in an introduction that seems related to viruses from Asia and California
oconnorlab retweeted
We continue to sequence Wisconsin viruses – recent viruses are nesting with previously identified clusters, consistent with ongoing community transmission. Physical distancing remains important! @GageKMoreno @tcflab @dho_lab
We've just added 33 new genomes from Wisconsin (red) to nextstrain.org/ncov thanks to @KATarinambraun @GageKMoreno @tcflab @dho_lab @GISAID! Several of these nest directly with previously sampled seqs from WI suggesting community transmission
oconnorlab retweeted
The new sequences from WI, USA cluster with previously sampled WI sequences within the North American clusters. Thanks to @KATarinambraun @GageKMoreno @tcflab @dho_lab!
Thanks to the efforts of David B., we now have a Wisconsin-centric version of the @nextstrain SARS-CoV-2 visualization with data collected by @GageKMoreno and @KATarinambraun openresearch.labkey.com/wiki…
oconnorlab retweeted
Thanks to everyone who tuned in to hear about the #SARSCoV2 / #COVID19 research happening at AVRL ! If you missed it you can watch it here: uwmadison.box.com/s/zl1warig…
@dho_lab – at Wisconsin, USA
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oconnorlab retweeted
Thanks to @LillyPad @MountSinaiNYC @KATarinambraun @GageKMoreno @tcflab @dho_lab @UNMHSC and @GISAID, we've added 153 genomes from the US (IL, WI, NY, WY)! Many NY genomes (orange, image 1) cluster with those previously sampled there. We also can now see transmission chains in WI
oconnorlab retweeted
SARS-CoV-2 nonhuman primate data through day 10 now available. Infected animals’ lung lesions seem to be improving. openresearch.labkey.com/proj…?