Postdoc in the @wick_wolfgang lab @DKFZ. Interested in #biomarkers for #glioblastoma using #multiomics Now at Bluesky @dirkchoffmann.bsky.social
Heidelberg, Germany
Joined November 2020
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Great study by @JulienHiblot and team who developed a chemical toolkit that allows tracking of calcium levels in live-time and much more! Well done 👏
🔬Ever wanted to spy on your model system? 🕵️♂️
Now you can! With bio-orthogonal chemical labeling, we've unlocked the ability to capture transient cellular events. 🌟
Dive in our study in @ScienceMagazine: science.org/doi/10.1126/scie…
A 🧵 1/15
As part of my PhD thesis @wick_wolfgang lab @DKFZ, @uniklinik_hd, @UniHeidelberg, @HdNeurooncology we investigated the cellular and molecular composition of tumor microtube networks in #Glioblastoma (1/6)
The manuscript is hot off the press @NatureComms:
nature.com/articles/s41467-0…
We thank all collaborators
@magnus_huppertz
@JulienHiblot
@HeuerSophieE
@AKourtesakis
@kaulen_leon
@Miriam__Ratliff
@ErikJung_HD
@VarunVenkatara2
@MarioSuva
@sahm_lab
@Winkler_Lab
@wick_wolfgang
on X and beyond, the DFG (unite-glioblastoma.de), and the patients (6/6)
Special thanks to Xless Ling Hai and Tobias Kessler who co-led this study.
We are looking forward to seeing the connectivity signature in action #GBM #BrainCancer @CancerNeurosci1 #CancerNeuroscience #CancerResearch #clinicaltrials
Great piece of work by my colleague @kaulen_leon at @wick_wolfgang lab in collaboration with @sahm_lab and @bb_610. This study sheds light on the mutational and transcriptomic landscape of Epstein-Barr virus-transformed primary CNS lymphoma. @DKFZ @HdNeurooncology
Pleased to share our 📰, which defines the genetics of EBV+ PCNSL using WES/RNASeq. Our work establishes EBV+ PCNSL as a distinct molecular entity and identifies alterations, which pave the way for targeted therapies. @HdNeurooncology @DKFZ @NeuroOnc link.springer.com/article/10… 🧵:
Dirk Hoffmann retweeted
Incredibly proud to share our latest work (tinyurl.com/2wumvwsn) published in @CellCellPress. This is the fruit of my postdoctoral training with @BradEBernstein at @DanaFarber @broadinstitute and @harvardmed. Now a thread about the science 🧵👇 #glioma #CELL #CancerResearch
Dirk Hoffmann retweeted
Spatial epigenome–transcriptome co-profiling of mammalian tissues | Nature nature.com/articles/s41586-0…
It was a pleasure to participate in the 1st #CancerNeuroscience Conference in Heidelberg. Great lineup of speakers, lively interactions and new collaborations - already looking forward to the next one. #Glioblastoma #HCCN2023
Dirk Hoffmann retweeted
We’re excited to share our preprint on spatial organization in glioblastoma: doi.org/10.1101/2023.07.06.5…. We combine spatial transcriptomics (Visium) and proteomics (CODEX) to reveal a five-layer organization of cellular states and highlight a role of hypoxia as tissue organizer. 1/
Wonderful collaboration between the teams led by @VarunVenkatara2 and @Prevedel_Lab. Pathing the way for understanding spatiotemperal evolution of #Glioblastoma.
#CancerNeuroscience
1/ We're thrilled to share our preprint on Deep3P - a new approach that takes us on a deep dive into the world of brain tumors, using three-photon microscopy and #AI. This exciting endeavor is brought to life together with the amazing @Prevedel_Lab ! tinyurl.com/mpz3extr
In this amazing work led by my colleague @Miriam__Ratliff @Winkler_Lab
@DKFZ, we leverage the power of genetic reporters, microscopy and single cell transcriptomics to decipher the interrelation of proliferation and invasion in #GBM. A perfect collab😍 #BrainCancer #Neurooncology
Glioblastoma: do cells that "go" also "grow"?
We now show in @NeuroOnc that invading GB cells are proliferative and less connected to the tumor network. After colonisation the cells become part of the network and slow-cycling.
Curious? doi.org/10.1093/neuonc/noad1… and a 🧵👇
Really insightful and interesting study! Well done @MA_Karreman and team @Winkler_Lab! 👏
#ICYMI— Active remodeling of capillary endothelium via cancer cell-derived MMP9 promotes metastatic brain colonization, by @Winkler_Lab, @MA_Karreman et al.
bit.ly/44ieznQ
Dirk Hoffmann retweeted
HCCN is an excellent opportunity for newcomers and experts to get a deep insight into this very new and intriguing field between neuroscience and oncology in- and outside the brain!
Join the Heidelberg Conference on Cancer Neuroscience (HCCN) @DKFZ in Heidelberg on July 18th and 19th, 2023 - it is the first international meeting of the field!
Abstract Submissions are open until June 15th.
cancerneuroscience.de/confer…
Dirk Hoffmann retweeted
Happy to share our work on TRAF7muts in meningioma/congenital heart disease. Shared genetics can be traced to common neural crest origin. Mutations disrupted scaffold protein function and caused cilia defects. @YNeurosurgery @PETERJIN999 @HdNeurooncology
pnas.org/doi/10.1073/pnas.22…
We offer a PhD position in the @wick_wolfgang lab at the crossroads of medicine and #Glioblastoma biology. Curious? Get in touch with me or us and find more information on our and the @DKFZ PhD program´s websites.
Would be happy to be your future colleague! =)
Apply now for the Summer Selection of the International #PhD Program at the German #Cancer Research Center, covering all areas of #cancerresearch, including #datascience, #bioinformatics, #epidemiology, #medicalphysics. To apply for your #PhDatDKFZ visit bit.ly/2WKlVwR
Well done Mirco and whole team! 👍Excited to see further applications of the system
Next one out (and first paper with Feng Zhang @ Broad Institute of MIT and Harvard): Spearheaded by the amazing grad student Joe Kreitz, we developed a complete new system for future in vivo gene therapy delivery:
Check it out! ⬇
nature.com/articles/s41586-0…
