Assistant Professor @tcddublin. Neuroimmunology in CNS disease and repair. Previously @broadinstitute, @HHMIJanelia and @cambridge_uni🇮🇪🇪🇺🏳️‍🌈

Dublin, IRL
Joined September 2018
🧵1/ How does the brain repair myelin after injury? We mapped the full cellular choreography of white matter repair using snRNA-seq + Slide-seqv2, uncovering a type I interferon-driven glial program that recruits lymphocytes to promote remyelination. biorxiv.org/content/10.1101/…
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📢 New webinar coming soon 📢  Ozgun Gokce @ozgungokce from German Center for Neurodegenerative Diseases will be our next speaker on October 7th. Check all the information in the flyer and add it to your calendar!
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I am hiring a Postdoctoral Fellow. Please share with your colleagues and feel free to reach out for an informal chat if interested.
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Incredible work, congratulations @Oliver__Hahn
Can you rejuvenate an old brain by giving it young immune cells? 🧠 My lab @calico put it to the test. In our new study, we replaced the brain's immune cells in old mice with young ones. The result? The old brain environment forced the young cells to age RAPIDLY. A 🧵👇
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The Department of Genetics at Trinity College Dublin is hiring a new faculty member. Come join our lively, diverse and collaborative group of investigators. my.corehr.com/pls/trrecruit/…
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There's also a grant mechanism for international talent from @Researchirel to get significant start up funds to do top tier research in Ireland ! researchireland.ie/funding/g…
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Fantastic opportunity to join and amazing lab!
We are very excited to be hiring a Postdoc to our expanding team! Are you interested in neuroinflammation, immunometabolism and/or epilepsy research?? 🧠📷 Apply now 📷my.corehr.com/pls/coreportal…… @Futureneuro_ie @RCSIPharmBioMol **********Closing date 16th July**********
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Fantastic new molecular technology from @Don_B_Arnold lab.
ATLAS, a rationally designed transsynaptic tracer is out today! Plasmids will soon be available on @Addgene addgene nature.com/articles/s41592-0… Many thanks to first authors Jackie Rivera and Haoyang Huang, and to collaborators, @blsabatini @Kanoski_Lab @vincentw_weng @beherring
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Delighted to give a talk at the wonderful @CentreMyelin annual symposium in Cambridge, UK. Truly fantastic conference and an amazing community. Thank you to @ThoraKaradottir and @mssocietyuk for organising!
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Today, we are launching the first publicly available AI Scientist, via the FutureHouse Platform. Our AI Scientist agents can perform a wide variety of scientific tasks better than humans. By chaining them together, we've already started to discover new biology really fast. With the platform, we are bringing these capabilities to the wider community. Watch our long-form video, in the comments below, to learn more about how the platform works and how you can use it to make new discoveries, and go to our website or see the comments below to access the platform. We are releasing three superhuman AI Scientist agents today, each with their own specialization: A general-purpose agent (Crow); An agent to automate literature reviews (Falcon); and An agent to answer the question “Has anyone done X before” (Owl). We are also releasing an experimental agent, Phoenix, that has access to a wide variety of tools for planning experiments in chemistry. More on that below. The three literature search agents (Crow, Falcon, and Owl) have benchmarked superhuman performance. They also have access to a large corpus of full scientific texts, which means that you can ask them more detailed questions about experimental protocols and study limitations that general-purpose web search agents, which usually only have access to abstracts, might miss. Our agents also use a variety of factors to distinguish source quality, so that they don’t end up relying on low-quality papers or pop-science sources. Finally, and critically, we have an API, which is intended to allow researchers to integrate our agents into their workflows. Phoenix is an experimental project we put together recently just to demonstrate what can happen if you give the agents access to lots of scientific tools. It is not better than humans at planning experiments yet, and it makes a lot more mistakes than Crow, Falcon, or Owl. We want to see all the ways you can break it! The agents we are releasing today cannot yet do all (or even most!) aspects of scientific research autonomously. However, as we show in the video, you can already use them to generate and evaluate new hypotheses and plan new experiments way faster than before. Internally, we also have dedicated agents for data analysis, hypothesis generation, protein engineering, and more, and we plan to launch these on the platform in the coming months as well. Within a year or two, it is easy to imagine that the vast majority of desk work that scientists do today will be accelerated with the help of AI agents like the ones we are releasing today. The platform is currently free-to-use. Over time, depending on how people use it, we may implement pricing plans. If you want higher rate limits, especially for research projects, get in touch. @m_skarlinski, @andrewwhite01, @_tnadolski, Remo Storni, @semajazarb, @ludomitch, @MichaelaThinks, as well as @jasonjoyride and his team for making such fantastic videos of us!
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9/ None of this work would be possible without the mentorship of @stevens1lab and @macosko. Or the hard work of two phenomenal RAs: Raphael Rakosi-Schmidt and Eric Garcia! Thank you to all our collaborators and coauthors!
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