Motivated to understand and better the conditions of life @ CompNeuro Lab, Monash University. What survives is not us; what survives is the story of us.

Oz
Joined July 2019
1/16 Our work is now published in @Nature. The psychedelic brain is often described as desynchronised or entropically disordered. That is true, but incomplete. Beneath the apparent disorder, we found structured brain activity aligned with context. nature.com/articles/s41586-0…
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Psychedelics can transform experience. Preparation for psychedelics can shape how this transformation unfolds. Could meditation-based preparation support psychedelic transformation? Prior research has found that an individual’s state of mind predicts both the quality of a psychedelic experience and its therapeutic outcomes. Meditation can shift one's mind state, yet it remains largely unexplored as a way to prepare for psychedelic experiences. Our new paper, "Practitioner perspectives on meditation-based preparation for psychedelic experiences," in press at Mindfulness, explores how meditation may support psychedelic preparation. We surveyed 123 individuals from 24 countries, all of whom were regular meditators who had at least one high-dose psychedelic experience (such as from psilocybin or LSD). They rated the benefits they believed meditation training can offer, which specific practices might help most, and how a preparation program could be designed and implemented. Here are the key themes that emerged: ➡️ Meditation was consistently rated as beneficial for psychedelic preparation. Participants perceived meditation as helpful across several dimensions, including post-session integration, increasing the likelihood of positive experiences, gaining helpful insights, and creating lasting benefits. ➡️ Meditation was thought to support psychedelic experiences by enhancing psychological acceptance, present-moment focus, and feelings of boundlessness while reducing anxious ego-dissolution. ➡️ Participants rated loving-kindness meditation as the most helpful practice type for psychedelic preparation, followed, in order, by open monitoring, self-transcendence, and focused attention. ➡️ Among participants with less meditation (1-3 years) and psychedelic (1-20 sessions) experience, those adhering to specific meditation traditions reported significantly higher perceived benefits compared to non-adherents. This pattern was reversed for highly experienced meditators (10+ years) with less psychedelic experience. ➡️ Regarding implementation, participants indicated preferred three weeks of preparation at about 30 minutes daily, with a majority favoring online (86.2%) and asynchronous (84.6%) delivery methods. Because we recruited participants experienced in both meditation and psychedelics, our sample may have favored those who already viewed both positively and were therefore more receptive to combining them. Future trials should test whether meditation-based preparation improves clinical outcomes for psychedelic interventions, while rigorously assessing the safety and adverse events related to this context. Full manuscript PDF: meditation.mgh.harvard.edu/f… My gratitude to first author Rosalind G. McAlpine (@rosmcalpine) and co-authors Merve Utangac, Joanna Kuc (@joanna_kuc), Henok Pankhurst, Amelia Sellers, Doug Kraft, Andrew Litchy, Naina E. Gupta, Christopher Timmermann (@neurodelia), and Sunjeev K. Kamboj (@sunjeevk). I’m grateful to the participants who shared their experiences and perspectives, making this research possible. May this work benefit many 🙏 #contemplativescience #psychiatry #wellbeing #advancedmeditation #mentalhealth
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Devon Stoliker retweeted
Super excited to see our work published in @Nature! This was a tremendous collaborative effort led by @dpsyc42 and @adeelrazi, and I’m grateful to have contributed to the work through core machine-learning and analytical components of the study.
Our new paper in @Nature is now out. Psychedelics don’t simply disorder the brain. Using fMRI, EEG and AI in 62 psychedelic-naive adults, we found hidden, context-sensitive organisation beneath the apparent chaos -- strongest in people reporting more positive, profound experiences and a reduced sense of separation from the world. The paper: nature.com/articles/s41586-0… Huge congratulations to @dpsyc42 who led from the front, @novelli_leo and @MKhajehnejad were exceptional in performing highly sophisticated and complex data analyses and thanks the whole @ConnectPsi team and collaborators. Our explainer: theconversation.com/new-rese… Data descriptor: nature.com/articles/s41597-0… ML model (TAVRNN): nature.com/articles/s42003-0… Fully open-access dataset: openneuro.org/datasets/ds006… Code for processing and cleaning data: github.com/razilab/psiconnec… @matthewdgreaves Tmarin Barta, @ManaBiabani, @SidChop, @anilkseth, @RCarhartHarris, @FredBarrettPhD, @KatrinPreller, @gary_egan @turnerinstitute @MonashPsych, @Monash_FMNHS, @MonashUni @CIFAR_News
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Devon Stoliker retweeted
Rather than just scrambling neural activity, the psychedelic substance psilocybin also reorganizes brain dynamics so as to align with a person’s context and experiences go.nature.com/4qu8j8e
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Devon Stoliker retweeted
Want to know what our @Nature paper found, and what it actually means? This excellent thread from @dpsyc42 breaks down the complexity of the analyses and walks through the key findings beautifully.
1/16 Our work is now published in @Nature. The psychedelic brain is often described as desynchronised or entropically disordered. That is true, but incomplete. Beneath the apparent disorder, we found structured brain activity aligned with context. nature.com/articles/s41586-0…
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Nature最新論文。シロシビンは脳を単に「無秩序化」するのではなく、音楽・瞑想・視覚刺激など、その時の文脈に合わせて脳活動を再編成することが示さレました。サイケデリック体験を「脳のカオス」から「文脈への適応」と捉え直す研究といえます。 Psilocybin may not simply make the brain more chaotic—it reorganizes brain activity to align with context, including music, meditation, and visual stimuli. A new view of psychedelic states as context-sensitive brain dynamics. nature.com/articles/s41586-0…
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Devon Stoliker retweeted
In a Melbourne lab, a volunteer swallowed a psilocybin capsule, slid into an MRI scanner, and began to merge with it. "Melding with the MRI machine, floor, walls, air," they reported afterward. Another volunteer described losing all sense of self and becoming "at one with all my surroundings ... as part of a bigger network of things." Sixty-two adults went through that scanner. None had ever taken a psychedelic. It's the largest single-site brain imaging study of a psychedelic ever run, and Nature published it this morning. Half now rank it among the most meaningful experiences of their lives, even though it happened inside a metal tube. For a decade, brain scans told a story of disorder, activity dissolving into noise. A 2024 Nature paper was titled "Psilocybin desynchronizes the human brain." Headlines translated... Psychedelics scramble your mind. This team looked closer, and inside the noise they found order. Instead of averaging brain activity over the scan, they used machine learning to track it moment by moment as people rested, meditated, listened to music, and watched a movie. Under psilocybin, each context carved its own pattern in the brain. Networks that normally wall your inner world off from the outer one started working together. And the deeper a person's sense of self dissolved, the more precisely their brain aligned with whatever surrounded them. The researchers named the state embeddedness: not connected to your environment, which still implies two separate things, but continuous with it. The boundary between you and everything else is not something your brain perceives. It's a construction your brain actively maintains every waking second, and psilocybin relaxes it. And the volunteers who dissolved deepest changed the most: bigger mindset shifts the next day and, a month later, measurable gains in personal meaning, closeness to nature, and acceptance of death. The visuals contributed far less. The dissolving drove it. Remember that the next time a startup pitches a psychedelic with the trip engineered out. It's the strongest brain-level case yet for what practitioners have insisted on since the 1950s. Under psilocybin, the brain doesn't just notice the room. It joins the room. The music, the space, and the person beside you become part of the medicine. I've built a decade of work on that principle, and as of today it has a Nature paper behind it. The authors close with a sentence I'll carry for a while... Psychedelics may reveal less about what they add to consciousness "than about what ordinary neural dynamics keep apart."
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Devon Stoliker retweeted
Our new paper in @Nature is now out. Psychedelics don’t simply disorder the brain. Using fMRI, EEG and AI in 62 psychedelic-naive adults, we found hidden, context-sensitive organisation beneath the apparent chaos -- strongest in people reporting more positive, profound experiences and a reduced sense of separation from the world. The paper: nature.com/articles/s41586-0… Huge congratulations to @dpsyc42 who led from the front, @novelli_leo and @MKhajehnejad were exceptional in performing highly sophisticated and complex data analyses and thanks the whole @ConnectPsi team and collaborators. Our explainer: theconversation.com/new-rese… Data descriptor: nature.com/articles/s41597-0… ML model (TAVRNN): nature.com/articles/s42003-0… Fully open-access dataset: openneuro.org/datasets/ds006… Code for processing and cleaning data: github.com/razilab/psiconnec… @matthewdgreaves Tmarin Barta, @ManaBiabani, @SidChop, @anilkseth, @RCarhartHarris, @FredBarrettPhD, @KatrinPreller, @gary_egan @turnerinstitute @MonashPsych, @Monash_FMNHS, @MonashUni @CIFAR_News
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13/16 Thus, “disorder” and “order” are not opposites here. Time-averaged desynchronisation can coexist with low dimensional temporal order. The method and timescale determine which is visible, showing why individual-level, time-resolved analyses matter.
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16/16 Paper: nature.com/articles/s41586-0… Open data: openneuro.org/datasets/ds006… Descriptor: nature.com/articles/s41597-0… We hope these resources support more individual-level, time-resolved and context-sensitive work on psychedelic brain dynamics.
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Additional thanks to our co-authors @anilkseth @RCarhartHarris @FredBarrettPhD @KatrinPreller and to the full author, clinical and research teams. Above all, thank you to the participants who made PsiConnect possible.
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10/16 We call the experiential correlate of context alignment “embeddedness”: felt continuity with a broader physical and psychological relational context. Whereas connectedness links entities that remain separate, embeddedness describes continuity between self and world.
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12/16 Our interpretation: ordinary brain dynamics maintain a distinction between internal models and external sensory context. Psilocybin reduces it, while brain activity becomes more temporally coherent within each context and more differentiated across contexts.
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11/16 This distinction captures what may be transformative: not merely feeling more connected, but less separate. Context alignment scaled with the depth of self- and boundary-dissolving experience and next-day mindset change, providing a measurable basis for embeddedness.
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