
Computational cancer biology @OxfordOncology 🧬 | Previously @EdinCRC @roslininstitute @ESA @CERN | Parent, gardener, cat butler 🏴 🇬🇧🇪🇺he/him
Edinburgh
Joined July 2008
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Incredibly honoured to have contributed to this work. Phenomenal teamwork and dedication!
'Our findings represent a significant advancement in understanding colorectal cancer.'
Ian Tomlinson (@OxfordOncology) comments on the most comprehensive analysis to date of the genetic makeup of #ColorectalCancer, just published in @Nature.
cancer.ox.ac.uk/news/ground-…
Steve Thorn 🦋 retweeted
Yesterday I presented a webinar about solving The Red Line Problem with PyMC. You can watch the video and get the slides here:
allendowney.com/blog/2024/07…
Come for the Bayesian statistics -- stay for the Banana of Ignorance!
Steve Thorn 🦋 retweeted
New paper! Maximally dysregulating APC should provide the maximal selective advantage to colorectal cancer cells? Doesn't appear so.
We quantify 'just-right' APC inactivation, at scale, in a variety of contexts, in our preprint:
doi.org/10.1101/2024.07.10.6…
Steve Thorn 🦋 retweeted
Finally published. In this paper we showed that despite heterozygous exonuclease deficiency of pold1 has a minor effect on the germline and somatic mutation rate. Homozygous deficiency increase mutation rate by 2 orders of magnitude and causes cancer nature.com/articles/s41431-0…
Our preprint about the role of POLD1 deficiency in soma and germline mutations is out. biorxiv.org/content/10.1101/…
Two main findings: surprisingly, POLD1 deficiency has a recessive effect on mutation rate; POLD1 alters mutational spectra to the same degree in soma and sperm
Steve Thorn 🦋 retweeted
Our new youTube channel:
youtube.com/playlist?list=PL…
Comments welcome!
Steve Thorn 🦋 retweeted
Does a significant GSEA result also mean your groups are biologically distinct for that signature?
In short; no
To avoid inaccurate interpretation, we developed “dualGSEA” to distinguish Statistical Significance & Biological Distinction
Preprint: biorxiv.org/content/10.1101/…
🧵👇
Steve Thorn 🦋 retweeted
A cat co-authored a scientific paper in 1975, when his owner, a physicist named Jack H. Hetherington, decided to add him as a second author to avoid changing the plural pronouns in his manuscript. The cat’s name was Chester, and he was given the pen name F.D.C. Willard, which stood for Felix Domesticus, Chester. Willard was also the name of Chester’s father. The paper was about atomic behavior at different temperatures, and it was published in Physical Review Letters, a prestigious physics journal.
Chester’s co-authorship was revealed when Hetherington sent some signed copies of the paper to his friends and colleagues, and included the cat’s paw prints as his signature. The story became widely known and amused many people in the scientific community. Chester even published another paper as the sole author in 1980, in a French popular science magazine. He died in 1982, but he is still remembered as the first and only cat to have authored a published scientific paper.
Steve Thorn 🦋 retweeted
We are looking for a Research Assistant to join our fabulous new group at @EdinUni_IGC studying liver plasticity and cancer. Come join our team!
elxw.fa.em3.oraclecloud.com/…
Steve Thorn 🦋 retweeted
My "Friends don't let friends make bad graphs" repository has reached 1000+ stars on GitHub! I can't believe it! Thanks everyone for the interest and support. Gonna add this to my CV. 😂😂😂
github.com/cxli233/FriendsDo…
Steve Thorn 🦋 retweeted
Did you miss out on our summer #bioinformatics workshops? Good news - lectures are now available on our Youtube channel, with all our course materials on bioinformaticsdotca.github.i… . Keep reading for a listing of everything we've recently published (for free!)... 🧵#OpenScience
Steve Thorn 🦋 retweeted
Really excited to share our paper out today! We show how germline de novo mutation rates and signatures are associated with parental germline mutation status in POLE, POLD1 and MUTYH 🧬
Huge thanks to everyone involved! @EdinCRC @group_tomlinson @clpalles
nature.com/articles/s41467-0…
Steve Thorn 🦋 retweeted
We are now hiring a core-funded PDRA position
***Please share!!***
Interested in #sustainable #invertebrate #aquaculture #immunology & molecular biology??
Enquiries welcome.
Full details here 👇
elxw.fa.em3.oraclecloud.com/…
Steve Thorn 🦋 retweeted
📣Our work on identifying cancer subtypes by splicing signatures came out @NatureComms nature.com/articles/s41467-0… 😀🎊Beautiful work led by the incredibly talented David Wang 👏💪. Why am I excited about it? 🧵 1/n
Steve Thorn 🦋 retweeted
In the LLM-science discussion, I see a common misconception that science is a thing you do and that writing about it is separate and can be automated. I’ve written over 300 scientific papers and can assure you that science writing can’t be separated from science doing. Why? 1/18
Steve Thorn 🦋 retweeted
6 incredible resources developed by top universities to help you become a proficient academic writer — totally free:
Steve Thorn 🦋 retweeted
Congratulations to Nathalie Feeley (best presentation) & Sarah Taylor (runner-up) during today’s series of 3rd/4th Year PhD-students talks in @EdinCRC @EdinUni_IGC. The event was organised by Prof Susan Farrington and recognition comes from voting by their fellow students! 👏👏
Steve Thorn 🦋 retweeted
In 1993 BMJ asked Doug Altman🇬🇧to write a few 600-word “filler” pieces on statistics education. The result was BMJ’s *Statistics Notes* series, mostly co-authored with JM Bland🇬🇧. The 67 articles are called “perhaps the finest series of short articles on the use of statistics”





























