@durocherlab

We are located at the Lunenfeld-Tanenbaum Research Institute and work on understanding the fascinating processes underlying genome integrity

 Toronto, Ontario, Canada
durocherlab.org
Joined April 2011
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  • Following2.2K
  • Followers3.1K
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durocherlab retweeted
Cell@CellCellPressAug 26
Now online! DDIAS shields single-stranded DNA in mitosis and promotes vertebrate brain development dlvr.it/TVB4mR

DDIAS shields single-stranded DNA in mitosis and promotes vertebrate brain development

DDIAS is identified as a factor that protects single-stranded DNA during mitosis to maintain chromosome stability, and inactivating mutations in DDIAS are identified in a human neurodevelopmental...

cell.com
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Online Now: Mitotic single-stranded DNA suppression by DDIAS dlvr.it/TV9XqY
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Incredible stuff from Tiger in Pelletier lab
Tiger Jian@tigerhzjianMar 25
(1/6): How can we better test therapeutics without using animals or risking lives? Lab-grown human mini-organs, called “organoids”, provide an answer! Despite their progress, organoids and related methods lack realistic flow through blood vessels, the “plumbing” of our bodies.
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durocherlab retweeted
Artem Babaian@RNA_LifeJan 15
Molecular Genetics @ University of Toronto 🇨🇦@UofT🦠 is recruiting an Assistant Professor in #Virology!! Come build your dream lab! 🔗jobs.utoronto.ca/job/Toronto…

Assistant Professor - Virology

Assistant Professor - Virology

jobs.utoronto.ca
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Ce jour nous rappelle solennellement les graves conséquences de la violence fondée sur le sexe. En mémoire des 14 jeunes femmes assassinées à Polytechnique Montréal, réaffirmons notre devoir de combattre cette violence et d’associer le souvenir à l’action. ow.ly/oihy50XExBH
Plaque installée à l’École polytechnique à la mémoire des quatorze victimes du massacre survenu à Montréal le 6 décembre 1989.

ALT Plaque installée à l’École polytechnique à la mémoire des quatorze victimes du massacre survenu à Montréal le 6 décembre 1989.

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Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1101/… With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
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durocherlab retweeted
Dan Landau@landau_lab14 Oct 2025
Big, beautiful trees!! SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life. biorxiv.org/content/10.1101/…
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New work from the lab! 🔬 We report that DDIAS is a new component of the mitotic CIP2A-TOPBP1 pathway of genome maintenance. biorxiv.org/content/10.1101/…

Mitotic single-stranded DNA suppression by DDIAS

Incomplete DNA replication and chromosome breakage during mitosis pose major threats to chromosome segregation. The CIP2A-TOPBP1 complex acts to mitigate this peril, but its exact role is not yet...

biorxiv.org
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Longer thread on the Blue site. Thanks to all authors and collaborators, chiefly Yibo Xue but that's not all!
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Kaima Tsukuda and Andy Blackford have a highly complementary study that indicates that mutations in DDIAS (and CIP2A) caused neurodevelopmental defects, pointing a role for this pathway in development. /fin biorxiv.org/content/10.1101/…

DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosis

DNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome...

biorxiv.org
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Job Alert 🚨 We are looking for outstanding candidates to join our institute! Find out more & apply: Biomedical Discovery ➡️ apply.interfolio.com/172703 Population Health Data Science ➡️ apply.interfolio.com/172529
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JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. nature.com/naturecareers/job… Please repost!
Image of Toronto

ALT Image of Toronto

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⚠️DEADLINE APPROACHING ⚠️ #BGFP25 early bird and talk submission deadline closes on 30 Jan 2025! 🧬 Don't miss out on the opportunity to present at this fantastic conference, submit your abstract now ➡️ bit.ly/3AnsVZF
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In a Review now available online, Natalie Ngoi, David Gallo, Carlos Torrado, Mirella Nardo, Daniel Durocher & Tim Yap provide an updated and comprehensive overview of the role of systhetic lethal strategies in cancer therapy nature.com/articles/s41571-0…
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Excited that our work on transcription-coupled DNA repair is now published @CellCellPress! We recapitulated TC-NER in Xenopus egg extract and identified STK19 as a core repair factor that couples stalled Pol II to TFIIH. 🧬🐸 ➡️ cell.com/cell/fulltext/S0092…
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durocherlab retweeted
Cell@CellCellPress30 Sep 2024
Now online! Pervasive mislocalization of pathogenic coding variants underlying human disorders dlvr.it/TDrxKg
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Postdoc positions in the @MRSantosLab! Please RT. Upcoming departure of several very successful lab members + new funding = postdoc positions! Exciting new avenues in mouse development, hypertranscription, dormancy and environment-epigenome interactions. mrsantoslab.org

Santos Lab

mrsantoslab.org
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Great start of the Durocher lab retreat. Some of the entries to our lab meme effort! You may notice a theme....
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