@ed_battey

Post doc in the Sylow lab at the University of Copenhagen | Investigating the regulation and mechanisms of action of Rho GTPases in skeletal muscle

 Copenhagen, Denmark
Joined April 2020
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  • Following558
  • Followers236
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New pre-print from the lab @Metabolcenter spearheaded by PhD student @shoreseashell & in collaboration with the Zeqiraj group @UniversityLeeds ; providing structure-based molecular insights & cellular actions of the potent #AMPK inhibitor, BAY-3827 biorxiv.org/content/10.1101/…

Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827

Inhibition of AMP-activated protein kinase (AMPK) is under increasing investigation for its therapeutic potential in many diseases, including certain cancers. However, existing AMPK- inhibitors...

biorxiv.org
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I've joined blue sky ☀️ bsky.app/profile/edbattey.bs…
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We have an exciting opening for a postdoc in our lab @Kings_BHFCentre Hoping to appoint someone within the next few weeks. Link to advert here: my.corehr.com/pls/coreportal… Pls RT!
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In our latest study led by @tcppham, we found that the mitochondrial (mt) protein SLIRP is a PGC-1α target that regulates mt structure, respiration, and mt-mRNA in muscle. And exercise restored these functions, even with SLIRP disruption and low mt-mRNA! nature.com/articles/s41467-0…

The mitochondrial mRNA-stabilizing protein SLIRP regulates skeletal muscle mitochondrial structure...

Nature Communications - Muscle mass is lost in patients with diabetes, which is associated with mitochondrial disfunction. Here they show that SLIRP maintains muscle mitochondria and that exercise...

nature.com
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Ed Battey retweeted
Hao Yin
@HaoYin208 Nov 2024
Metabolic myofiber typing on Cryosections of mouse whole hindlimb muscle MYH7/MYH2/MYH4 co-staining MYH1 @DSHB_antibodies Videos: How to use Cryotome MyoVision 2.0 MuscleJ2 @Kei__Sakamoto @STARProtocols 2024 star-protocols.cell.com/prot…
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New protocol paper from the lab for muscle fibre typing in whole lower mouse hindlimbs. Spearheaded by former visiting researcher in our group @ed_battey ,supported by postdoc @itsmedipsikha & in collaboration with Pascal Maire & Matthew Dos Santos. star-protocols.cell.com/prot…
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#Cellsize is important for many cellular processes, including biosynthesis, organelle homeostasis and development. If you need an overview of how cell size is controlled, and how it affects cell function, we have you covered: doi.org/10.1152/physrev.0004… @YagyaChadha @arohikhurana1

Eukaryotic cell size regulation and its implications for cellular function and dysfunction |...

Depending on cell type, environmental inputs, and disease, the cells in the human body can have widely different sizes. In recent years, it has become clear that cell size is a major regulator of...

journals.physiology.org
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New pre-print from the lab spearheaded by former visiting researcher in our group @ed_battey & supported by postdoc @itsmedipsikha Protocol for simultaneous visualization of different muscle compartments in cryosections of whole lower mouse hindlimbs. biorxiv.org/content/10.1101/…

Protocol for muscle fiber type and cross-sectional area analysis in cryosections of whole lower...

We outline a robust, simple, and cost-effective method to simultaneously visualize all mouse lower hindlimb skeletal muscles. We describe procedures for orientating the whole lower hindlimb in gum...

biorxiv.org
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It's #FluorescenceFriday, and we love muscle fibers. So cool to visualize this plasma membrane-targeted biosensor in mature muscle fibers! It seems that the protein also allows us to see the T-tubule system (?) @ed_battey #FluorescenceFriday
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Fully funded PhD opportunity with myself, @AndrewCapel1988 and @Sportrometrist now available. Skeletal muscle sex differences | Postgraduate study | Loughborough University lboro.ac.uk/study/postgradua…
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In this work, driven by amazing postdoc in our team @A_Irazoki, we found that adaptations to cancer in mice critically depend on housing temperature. biorxiv.org/content/10.1101/…

Housing temperature dictates the systemic and tissue-specific molecular responses to cancer in mice

Cancer cachexia is a metabolic condition affecting up to 80% of patients with cancer. Cachexia is mediated by reduced muscle and fat mass and impaired function, and it lowers survival for patients....

biorxiv.org
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After countless requests, we're thrilled to introduce PK Mito Orange FX - a fixable variant of PKMO. PKMO FX allows immunolabeling and CLEM approaches. Happy to have contributed to this project led by @ZhixingChen2 and Christian Jüngst. #mitochondria pnas.org/doi/10.1073/pnas.23…
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How do endurance exercise and the ageing process affect the positioning and number of myonuclei within muscle fibres? Edmund Battey (@KclPhysiology) et al. investigate in this article! 📜buff.ly/3UuaytN
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Older people who regularly do endurance exercise maintain similar muscle health to younger people The research suggests inactivity has a greater effect on some muscle characteristics than simply getting older Read more 🔽 kcl.ac.uk/news/muscle-health…

Muscle health may be informed by activity level rather than ageing process | King's College London

A new study comparing muscle structure between active and inactive people has found that older people who regularly do endurance exercise maintain similar muscle characteristics to younger counterp...

kcl.ac.uk
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🧵1/ Our @stroud_lab @OchDr study, recently accepted in Experimental Physiology, on muscle fibre size and myonuclear positioning in exercise trained and aged humans. physoc.onlinelibrary.wiley.c…

Muscle fibre size and myonuclear positioning in trained and aged humans

Changes in myonuclear architecture and positioning are associated with exercise adaptations and ageing. However, data on the positioning and number of myonuclei following exercise are inconsistent....

physoc.onlinelibrary.wiley.com
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8/ Thank you to all collaborators @kingsmedicine @kingscardio @KCLBMBioscience involved in this effort and @KCL_MRCDTP @Kings_BHFCentre @KingsCollegeLon for funding the study.
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9/ Also thanks to the reviewers with whom we had valuable in-depth discussions and whose suggestions greatly improved the manuscript.
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