@ericjoycelab

Associate Professor, @PennGenetics @PennEpiInst 3D Genome structure and function

 University of Pennsylvania
ericjoycelab.com/
Joined July 2017
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  • Following677
  • Followers1K
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Patrick Walsh (@pjwalsh1688) in the @ericjoycelab defends his thesis tomorrow!
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Dr. Randi Isenhart (@isenhartrandi) has a new 1st author publication for her work in the @ericjoycelab on: The length and strength of compartmental interactions are modulated by condensin II activity: dx.plos.org/10.1371/journal.…

The length and strength of compartmental interactions are modulated by condensin II activity

Author summary The three-dimensional organization of the genome plays a critical role in regulating cellular function, yet the mechanisms that govern large-scale chromatin architecture during...

journals.plos.org
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We are deeply saddened by the loss of an esteemed colleague, friend, mentor & a pioneer in Drosophila & meiosis research. R. Scott Hawley was a dedicated supporter of GSA & a champion of genetics. Read an In Memoriam published in Genes to Genomes: buff.ly/3EoNQh8
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Exciting news 📃🧬🔬 Today we report on the dynamics of a fascinating class of molecular motors, so-called SMC proteins in @CellCellPress doi.org/10.1016/j.cell.2024.…
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Excited to share our latest work on bioRxiv! Using cell-cycle dynamics and NIPBL depletion, we show that long-range enhancer interactions can form de novo without loop extrusion. Alternative mechanisms, including LDB1 and YY1, may play key roles.biorxiv.org/content/10.1101/…

Cis-regulatory chromatin contacts form de novo in the absence of loop extrusion

NIPBL promotes chromatin loop extrusion by the cohesin complex until it stalls at convergently oriented CTCF sites, leading to the formation of structural loops. However, to what extent loop extrus...

biorxiv.org
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ft. @HarkeJailynn, Jeewon Lee, @SonCNguyen, Staci Rakowiecki, @rebecca_yunker, @doug_epstein, @ericjoycelab (@PennGenetics), Arian Arab, @Melike_Lak (@PennEpiInst) & @SHugelier (@UPennPhysiology) @MolecularCell cell.com/molecular-cell/abst…
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Congratulations @HarshiniChandr8 💐 Using human neurons homozygously-engineered with familial AD mutations, she found a role for miswired promoter-enhancer multi-loops in dysregulated excitatory and inhibitory gene expression programs BioRxiv: doi.org/10.1101/2024.02.27.5…
Genome Organisation Australia@GenomeOrgAus25 Nov 2024
We are excited to announce the winner of the GOA Young TAD for 2024 is @HarshiniChandr8 🏆🥇🏅 Congratulations to Harshini and also to the other finalists! The 3D genome field is in great shape with so many innovative young scientists!
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🚨Inter-chromosomal contacts (‘kissing chromosomes’) organize human genome topology along a spatial gradient of genome activity (62 Hi-C datasets). Check rdcu.be/dZYQw, @NatureComms, @4DNucleome, @The3DGenome, @humangenomeorg, @netscisociety, @Emblebi, @MoGen_Grads
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Happy to share work with Hadi, Yao & @Maxime_Tortora characterizing the impact of dynamic CTCF barriers for cohesin loop extrusion biorxiv.org/content/10.1101/…

Dynamic barriers modulate cohesin positioning and genome folding at fixed occupancy

In mammalian interphase cells, genomes are folded by cohesin loop extrusion limited by directional CTCF barriers. This interplay leads to the enrichment of cohesin at barriers, isolation between...

biorxiv.org
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First preprint from the lab 🚨 How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process? biorxiv.org/content/10.1101/… (1)

Synergy between cis-regulatory elements can render cohesin dispensable for distal enhancer function

Enhancers are critical genetic elements controlling transcription from promoters, but the mechanisms by which they convey regulatory information across large genomic distances remain elusive. Here,...

biorxiv.org
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Excited to share a new preprint! (1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function? biorxiv.org/content/10.1101/…
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1/🧬Does chromatin organization shape immune responses? Our recent study with @NickAdams_PhD led by Reizis Lab and @leonidmirny explores how cohesin, a key player in chromatin loop extrusion, controls the chromatin architecture essential for conventional dendritic cells (cDC)👇
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📣Sharing the latest research from the @MRSantosLab, just released on bioRxiv! We found LINE1 RNA promotes nuclear compartmentalization to repress the 8-cell state in human embryonic stem cells. biorxiv.org/content/10.1101/… 👇Key findings:

LINE1 promotes nuclear compartmentalization to repress the 8-cell state in embryonic stem cells

The family of LINE1 transposable elements underwent a massive expansion in mammalian genomes. While traditionally viewed as a mutagenic selfish element, recent studies point to roles for LINE1 in...

biorxiv.org
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Eric Joyce retweeted
zack chiang
@z_chiang26 Sep 2024
We then show these changes are found within tissues and during aging. To learn more, check out our preprint! Thank you to all co-authors, the Buenrostro lab, and everyone at @HSCRB & @broadinstitute who made this work possible! biorxiv.org/content/10.1101/…

Expansion in situ genome sequencing links nuclear abnormalities to hotspots of aberrant euchromatin...

Microscopy and genomics are both used to characterize cell function, but approaches to connect the two types of information are lacking, particularly at subnuclear resolution. While emerging multip...

biorxiv.org
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Eric Joyce retweeted
Jane Skok@jane_skok11 Sep 2024
Speaker Spotlight: @MariekeOudelaar from the Max Planck Institute will share exciting research on the mechanisms behind 3D genome folding and its role in gene regulation during cellular differentiation. Don't miss it! Register here 👉 bit.ly/chromatin-2024 #chromatin2024
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Excited to see our paper officially out in the August issue of @CD_AACR !
Cancer Discovery@CD_AACR3 Sep 2024
Condensate-Promoting ENL Mutation Drives Tumorigenesis in vivo through Dynamic Regulation of Histone Modifications and Gene Expression, Yiman Liu, Qinglan Li, @LilingWanLab, and colleagues. @PennMedicine @PennCancer @PennEpiInst @Penn_CBIO bit.ly/4cTwIvw
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Happy to share work with @Maxime_Tortora on modeling the physical chemistry of cohesin loop extrusion! biorxiv.org/content/10.1101/…

The physical chemistry of interphase loop extrusion

Loop extrusion constitutes a universal mechanism of genome organization, whereby structural maintenance of chromosomes (SMC) protein complexes load onto the chromatin fiber and generate DNA loops of...

biorxiv.org
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Happy to share my thesis work, now online at bioRxiv. We show that LDB1 organizes Enhancer-Promoter interaction networks and can function independently of cohesin! biorxiv.org/content/10.1101/…

LDB1 establishes multi-enhancer networks to regulate gene expression

How specific enhancer-promoter pairing is established is still mostly unclear. Besides the CTCF/cohesin machinery, only a few nuclear factors have been studied for a direct role in physically...

biorxiv.org
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Eric Joyce retweeted
Shiv Grewal@grewalsh2 Aug 2024
📢ACCESS DENIED!! Ever wonder how heterochromatin causes transcriptional gene silencing and is epigenetically inherited? Excited to share our new story showing that histone deacetylation, a conserved feature of heterochromatin domains from yeast to mammals, limits access to SWI/SNF chromatin remodelers to prevent unraveling of nucleosomes, which enforces gene silencing and maintains high H3K9me3 density required for epigenetic inheritance #epigenetics #heterochromatin #histones #chromatin Congratulations to @rakesh_k_sahu and other lab members! cell.com/molecular-cell/full…
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Happy to share our latest review, in which we discuss how small-scale 1D features of nucleosome positioning influence large-scale 3D genome folding patterns: sciencedirect.com/science/ar… Great team work with @abrarjah and @clemauksch!
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