@evanovoad

PhD at Molecular Metabolism CiMUS/IDIS

Joined February 2022
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🌞 It’s summer, and from the Molecular Metabolism group we’re contributing to your summer reading with a fresh new paper! 📚 Our latest study, “Resmetirom Ameliorates Fibrogenesis in HSC”, uncovers a new mechanism through which resmetirom may directly modulate liver fibrosis.
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We think that this work opens new questions about targeting thyroid hormone signaling in HSCs as a strategy against liver fibrosis. If you want to see more: onlinelibrary.wiley.com/doi/… #MASH #MASLD #LiverFibrosis #Resmetirom #Hepatology
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And, of course, science is always a team effort. ❤️ A huge thank you to everyone who contributed to this work, both within and beyond the Molecular Metabolism group. And a very special thank you to @CabaleiroAlba , my eternal companion in science. 🫶
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Hoy, en el Día de la Mujer Trabajadora, salimos en el periódico. Un orgullo compartir este logro y seguir avanzando en ciencia. Gracias especialmente a mi compañera @ParrachoTamara por su trabajo, esfuerzo y dedicación 💜🔬 lavozdegalicia.es/noticia/la…

Completar el puzle que lleva a la cicatrización del hígado: el objetivo de un equipo de investiga...

Una parte del grupo de Metabolismo Molecular del CiMUS, de la Universidade de Santiago, dedica su estudio al papel de las células estrelladas en la fibrosis

lavozdegalicia.es
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We are back!! I'm excited to share our new paper from @RubenNogueiras lab at @cimususc , where we identified the key role of PCK1 in liver fibrosis progression. Key findings below...👇
Cell Metabolism@Cell_MetabolismFeb 23
New! Online now: Lack of PCK1 in hepatic stellate cells causes liver fibrosis by fueling tricarboxylic acid cycle and increasing glycolysis dlvr.it/TR6mSR
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So, PCK1 protects the liver from scarring by keeping fibrogenic cells in a quiescent state. When PCK1 is reduced, these cells undergo metabolic reprogramming characterized by increased glycolysis, become aberrantly activated, and promote liver fibrosis in mice.
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Finally, this work wouldn't have been possible without our entire lab team and collaborators, but special thanks to @ParrachoTamara and @ChusaGzlzRellan for driving this project to success! 🔬
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I'm excited to share the findings from our recent study from @RubenNogueiras lab, where we investigated whether GLP-1 and GIP agonists have direct actions on human hepatocytes and hepatic stellate cells (HSCs)... Here is a brief summary of the newest findings...👇
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This work wouldn’t have been possible without the entire lab team, but I especially want to thank @CabaleiroAlba and Natalia for making this project a success. 🙌
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🔍 For more details, check out the full article here: link.springer.com/article/10…

GLP-1 and GIP agonism has no direct actions in human hepatocytes or hepatic stellate cells

Cellular and Molecular Life Sciences - The use of incretin agonists for managing metabolic dysfunction-associated steatohepatitis (MASH) is currently experiencing considerable interest. However,...

link.springer.com
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