ALT An illustration of the Open Targets project framework, and an example of an Open Targets research project showing the emergence and journey of a potential target lead through the workflow. We bring together publicly available data with data generated through the collaborative research program’s projects to provide causal evidence for target-disease associations as well as foundational knowledge related to genes and diseases. This knowledge is integrated into our open-source informatics platforms. Potential targets are fed into our validation lab for further mechanistic insights. The workflow at each step feeds into our industry partners’ drug discovery pipelines, and, once publicly available, into the wider scientific and drug discovery community, with the ultimate aim of helping to develop safer and more effective medicines