Tokenizing loops of antibodies has now been published in mAbs! Antibody loops are critical for binding, but hard to design. Our tokenizer, Igloo, learns multimodal tokens that capture sequence, structure, and similarity to other loops. Igloo can be used to: 🔍 retrieve similar loops for library design 🎯 generate similar CDR H3 loops 🤖 plug into protein language models 🧪 boost predictions of variant effects on binding affinity 💊 Diversity loops for library design of antibodies Link to paper and github below. Big thanks to: @frdreyer Rob Alberstein, and Simon Kelow @genentech