Assistant Professor at @jacksonlab | Brain tumor microenvironment No longer active here. https://xitter.cf/t.co/dQryRN49s9
Farmington, CT
Joined April 2009
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Latest work by the Glioma Longitudinal Analysis Consortium is out!
We integrated genomic, pathology, and microscopy approaches to discover common molecular paths gliomas take following therapy.
➡️ @CellCellPress link: authors.elsevier.com/c/1fAB3…
A 🧵on what we learned (1/10):
Fred Varn retweeted
We are thrilled to have published our recent findings regarding the way that GBM tumours adapt to, and survive, treatment in @GenomeBiology. This brief thread highlights what we found: 1/8
Fred Varn retweeted
It's Ph.D. application season! Ready for the next step in your scientific career? #PhDchat
Learn more & apply for JAX's exceptional Ph.D. program in mammalian genetics, neuroscience, or biomedical sciences: jax.org/phd
Fred Varn retweeted
Online Now: Transcriptome analysis reveals tumor microenvironment changes in glioblastoma dlvr.it/Skh20l
Today is officially my first day as an Assistant Professor at @jacksonlab in Farmington, CT. My lab will be applying genomic and pathology approaches to examine how the tumor microenvironment shapes evolution and treatment resistance in diffuse glioma
I want to thank my postdoctoral advisor, @roelverhaak, my PhD advisor, @chengchao12, the @JCCFund, as well as all my colleagues at JAX and in the brain tumor research community for their support. As a faculty, I plan to pay it forward
Fred Varn retweeted
We think we've found something v.interesting 🧐:IDHwt GBMs can be stratified by treatment response which might inform targeted therapies. Read our study here: tinyurl.com/3ybvwutd Funded by @UKRI_News @BRUKresearch @DiMeN_Diversity @LDShospcharity @OscarsCharity @YorkshireBTC
Fred Varn retweeted
We just published in Neuro-Oncology 🥳 GBMdeconvoluteR quantifies immune & neoplastic cells in bulk RNAseq of IDHwt GBM:tinyurl.com/2bpueaas. More research facilitated by @LeedsNeuroRTB funded by @YorkshireBTC and @OscarsCharity.
Congratulations to former summer student @Gordon_Y_Ye!
🎉 Congrats to @jacksonlab Summer Student alumni Emma Wade (left) & Gordon Ye (right) for being selected as 2023-24 Churchill Scholars! This competitive scholarship covers one year of master’s study at @ChurchillCol, a stipend and travel costs. Read more: bit.ly/3XzMLI6
ALT Emma Wade headshot
ALT Gordon Ye headshot
Fred Varn retweeted
🎉 Congrats to @jacksonlab Summer Student alumni Emma Wade (left) & Gordon Ye (right) for being selected as 2023-24 Churchill Scholars! This competitive scholarship covers one year of master’s study at @ChurchillCol, a stipend and travel costs. Read more: bit.ly/3XzMLI6
ALT Emma Wade headshot
ALT Gordon Ye headshot
Fred Varn retweeted
We'd love to hear back from the community about GBMdeconvoluteR, our tool to infer relative proportions of cancer & TME cells from bulk GBM RNAseq data biorxiv.org/content/10.1101/… Made possible thanks to funding from @UKRI_News @YorkshireBTC @OscarsCharity @3DBioImaging @BNS_updates
Fred Varn retweeted
Very happy to share our latest manuscript @CellCellPress with you: authors.elsevier.com/c/1fVaE…
TL;DR: Glioblastomas are incurable brain tumors colonizing the entire brain. We overlay molecular and functional data to uncover a hijacking of neuronal mechanisms driving invasion.
ALT Glioblastoma hijacks neuronal mechanisms for invasion. We find three neuronal layers: a molecular neuronal-like cell state driving glioblastoma invasion, neuronal-like cellular mechanisms and neuron-glioma synapses driving neurite-like sprouting of tumor microtubes.
Fred Varn retweeted
Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma dlvr.it/SS7TqG
Thanks for reading! It was an honor to work with so many great people on this project. I want to highlight @Kevin_C_Johnson, @JanMartinek1, @PaluckaLab, and the GLASS pathology team for their contributions; my mentor, @roelverhaak, and GLASS leadership for the guidance; (9/10)
The Jane Coffin Childs Memorial Fund (@JCChildsFund) for helping fund this work; and finally, the patients and their families whose donations made this study possible (10/10)