@gavinjknott

RNA Biochemist | Nucleic Acid Sensors | CRISPR | Lab Head @MonashBDI | Postdoc @doudna_lab | Ph.D. UWA. Views my own.

 Melbourne, Victoria
Joined April 2017
  • Tweets145
  • Following720
  • Followers1.4K
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Excited to share our new paper describing the structure of an SpCas9 adenosine base editor (ABE) out now @ScienceMagazine! Co-first authored with @Sarkele1, we captured a base-editor in the act using cryo-EM! science.sciencemag.org/conte… (1/5).
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We are excited to share pre-prints describing a successful foray into ML-driven protein design. With @Rhys__G we designed proteins to potently inhibit CRISPR-Cas13 (doi.org/10.1101/2024.12.05.6…) or block heme piracy by pathogenic E. coli (doi.org/10.1101/2024.12.05.6…):
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These are challenging targets, CRISPR which are large multi domain RNA binding proteins and ChuA - an uncharacterized transmembrane protein. End-to-end design and validation would not have been possible without the hard work of @CyntiaTaveneau @_danielfox and all co-authors!
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Did you enjoy @crispr2023 or want to come to the next one! The #crispr conference will be in ⁦@Christchurch_NZ⁩ organised by ⁦@PeterFineran⁩, ⁦@dsashital⁩ ⁦@gavinjknott⁩ and ⁦@drbridgetwatson⁩. Check out the website crispr2025.org
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Thrilled to share my remarkable journey visiting #MonashUniversity, #Melbourne. Blown away by the exceptional minds at the #KnottLab and #GreeningLab, where the synergy between dedication & innovation pushes the boundaries of scientific discovery. 1/2 #AcademicTravel🌏🔬🎓
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Hi #CRISPR enthusiasts. #CRISPR2024 is being hosted in #NewZealand by @dsashital, @gavinjknott, @drbridgetwatson and I. If you are thinking of attending, help us lock in a date by completing the following survey surveymonkey.co.uk/r/WYZM58Q. Pls RT @crispr2023
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An amazing opportunity to work with an incredible team on cutting-edge CRISPR research. Would highly recommend working with Audrey and her team at ASU!
Audrey Lapinaite@Sarkele116 Nov 2022
🚨We are hiring!🚨 The Lapinaite Lab is looking for a Postdoctoral Fellow #postdocposition with experience in #CryoEM. Join us and be part of an international team of researchers studying #CRISPR #baseediting #precisionmedicine #RNA How to apply: lapinaitelab.org/open-positi…

Open Positions — Lapinaite Lab

lapinaitelab.org
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🚨We are hiring!🚨 The Knott Lab is looking for a Postdoctoral Fellow with experience in #CryoEM. Join us and be part of a global and industry aligned team of researchers studying #CRISPR and #RNA. Details and how to apply: careersaustralia.monash.edu/…
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Gavin Knott retweeted
NOTDRS@NOTDRS_Monash8 Aug 2022
📢Seminar alert!! Don’t miss the chance to hear all about life as an overseas post doc from a line up of fantastic speakers: @gavinjknott @Dr_Ellisdon @QiZhang85 @monashbdi ➡️Join us in-person Tues 16th 10:30am AEST in s13, 11 rainforest walk for talks followed by light snacks!
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It’s been ~10 yrs since #CRISPR biotech exploded onto the scene. What’s new in the field and where is it headed? Join us in Berkeley for the 5th International Conference on CRISPR biotechnology to hear answers to these questions and more! More details - aiche.org/crispr
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Coot 1 is out and it’s cooler than ever!🎉 #ccp4 ✅ the GUI has been re-implemented ✅ the graphics has significantly improved, you can now export maps and models as glTF files to be used in #Blender3d and other 3D software. ✅ coot is now a module to be imported in Python 3
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Gavin Knott retweeted
Minni Anko@wilhelmstore8 Mar 2022
A-RNA Conference: Registrations open until April 1 and filling fast! The Inaugural Australasian RNA Biology and Biotechnology Conference will go ahead in Thredbo from 15-18th May. Details of the program can be found at a-rna.org. @ARNAconference #RNA
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Announcing our three new Snow Fellows! Congratulations to Gavin Knott @gavinjknott @MonashUni, Emily Wong @em6wong @VictorChangInst, and Stephin Vervoort @Stephintje @WEHI_research. Read more about their transformative research here snowmedical.org.au/our-snow-… #SnowMedical #EMCR
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Thank you to @SnowMedical and the Snow family for this incredible opportunity. It’s an honour to be named a Snow Fellow and my team and I are thrilled to enable #RNA research. Also, a huge congratulations to the incredible @em6wong and @Stephintje who received Snow Fellowships!
Tom Snow
@tomrsnow1 Mar 2022
Our family is VERY proud to be supporting three more amazing researchers through @SnowMedical… bringing our commitment to medical science to over $90 million theaustralian.com.au/higher-…
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Gavin Knott retweeted
Tom Snow
@tomrsnow1 Mar 2022
Our family is VERY proud to be supporting three more amazing researchers through @SnowMedical… bringing our commitment to medical science to over $90 million theaustralian.com.au/higher-…
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Up next at #SciencemeetsParliament: Join Australia’s Chief Scientist Dr Cathy Foley @ScienceChiefAu to open our welcome reception at 3.45 AEDT. We are so grateful for the generous support of @AbbVie_AU for this brilliant event. #SmP2022
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Awesome opportunities to work at the University of Rochester, seeking multiple tenure-track faculty using a cohort recruiting approach, and the ability to also join the Center for RNA Biology: nature.com/naturecareers/job… Happy to DM or chat about this, if interested!
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Building #mRNA therapeutics & #vaccine innovations in Victoria. Find out more about new grant funding opportunities to build mRNA capabilities & fast-track sovereign #manufacturing. Webinar by mRNA Victoria & @InvestVictoria. Tomorrow 9am. REGISTER NOW: lnkd.in/gii8567a
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Ever wondered where Cas9 came from? @Sarkele1 and I wrote a 'First Cut' for @CRISPRjournal describing the epic work by @altaetran and colleagues on the origins of Cas9. Our summary: liebertpub.com/doi/10.1089/c… The epic paper: science.org/doi/10.1126/scie… Phage be like👇
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Curious to know how the genome editor Cas9 unwinds DNA to "read" it? Check out this great story by @JoshCofsky from the @doudna_lab. When we saw the first cryo-EM maps Josh said: "WOW the DNA is like REALLY bent. This is what comes to mind when I'm thinking about the mechanism:"
Josh Cofsky@JoshCofsky7 Sep 2021
New pre-print! While #CRISPR-Cas9 searches through the genome, how does it actually "read" DNA sequence information, which is normally hidden within the double helix? We determined structures of Cas9 in the act of DNA interrogation to find out! Thread below 👇 (1/8)
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Really cool stuff from @raphaeljlt and the team at @StanfordAILab - one step closer to understanding the code that defines higher order RNA structure! Check it out here: science.sciencemag.org/conte…
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