Jeffrey Gagan MD, PhD (@grumpymdphd) header
Jeffrey Gagan MD, PhD (@grumpymdphd) profile picture

Molecular Pathologist at UTSouthwestern. I get into lots of arguments about large language models and medicine. @MedicineUVA @BWHPath @UTSW_Pathology

Dallas, TX
Joined May 2014
Photo by Jeffrey Gagan MD, PhD (@grumpymdphd)Photo by Jeffrey Gagan MD, PhD (@grumpymdphd)Photo by Jeffrey Gagan MD, PhD (@grumpymdphd)Photo by Jeffrey Gagan MD, PhD (@grumpymdphd)Photo by Jeffrey Gagan MD, PhD (@grumpymdphd)Photo by Jeffrey Gagan MD, PhD (@grumpymdphd)Photo by Jeffrey Gagan MD, PhD (@grumpymdphd)Photo by Jeffrey Gagan MD, PhD (@grumpymdphd)Photo by Jeffrey Gagan MD, PhD (@grumpymdphd)Photo by Jeffrey Gagan MD, PhD (@grumpymdphd)
Jeffrey Gagan MD, PhD retweeted
In this upcoming webinar, Dr. Annapurna Saksena of the University of Pennsylvania, will discuss the relationships of methylation-defined groups to a variety of HL tumor types to determine the feasibility of methylation as a diagnostic modality. Register now.

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I just had a cashier tell me “Stay safe out there” and she was referring to driving when the Texas-Oklahoma football game ends.
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I just got back from a nature photography workshop in Jackson Hole. It was a great experience, and the primary lesson for me is that always being the expert in the room is unhealthy. Find situations where you are at the bottom of the learning curve and push yourself up it.
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Happy birthday to my amazing wife @emilygironda. Spending my life with someone who wants to go a K pop concert one week and then the opera the next has been amazing. I can't wait to see what new adventures and rabbit holes we find ourselves down in the future.
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To anyone thinking of reminding me, I promise I know when the USCAP submission deadline is. It's circled on my calendar every year.
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Splice variant analysis time: Variant in the -1 site, first thing to check is whether the VAFs in the DNA and RNA are equivalent. In this case they are.
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There are a bunch of reads where the splice donor site is moved 1bp into the exon.
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Both exons have a "G" in the exon-intron boundary position, so it's ambiguous to the mapper where it belongs when deleted. So look at the first image again. The G>A variant destroys the normal splice site, but creates a new one just shifted 1bp, creating a frameshift mutation.
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Don't procrastinate on getting your hotel either. Speaking from experience on this one!
Registration for #AMPath23 is OPEN! Join your colleagues in stunning Salt Lake City, UT for three days of exciting #molpath programming. Early Bird registration ends September 20: ow.ly/ocoW50P2RAN #pathtwitter
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Tumor Sample is Bone Marrow, "Normal" is from saliva. What is the diagnosis (or diagnoses)?
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Jeffrey Gagan MD, PhD retweeted
2 different men have asked me for a book to snap them out of a prolonged reading slump (I’m an English teacher; I have answers). Gentlemen, the answer is always Mistborn @BrandSanderson We need a public health campaign for 30-45 yo men who forgot how to read. I’ll print leaflets
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The fluorescent light just outside of my office just started turning on and off every few seconds. If anyone needs me, I'll be gradually losing my mind for the rest of the day.
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Jeffrey Gagan MD, PhD retweeted
Replying to @mnali
This is an example of something I call NGS: Nagging Grandparents’ Syndrome Someone is excited about something, and grandma or grandpa says, “Wait a second” and lists off everything that can go wrong People online feel very smart doing this but it’s basically poor social skills
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Most photos in a patient chart feel like hospital mugshots. One patient chart I was reviewing today, he had uploaded a jaunty portrait with MyChart. I obviously can't identify him at all, but I just want to put it out in the world that it made my day.
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Jeffrey Gagan MD, PhD retweeted
#OpenAccess in @Nature from Piro Lito @MSKCancerCenter Pan-KRAS inhibitor disables oncogenic signalling and tumour growth nature.com/articles/s41586-0… An allele agnostic non covalent KRAS inhibitor that binds to the KRAS OFF state; from @Boehringer (@D_B_McConnell @norbertkraut1)
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Jeffrey Gagan MD, PhD retweeted
Are you a budding science writer? We're looking for an intern to work with us on the Science and technology desk at @TheEconomist. You'll spend 3 months with us in London, working on articles, newsletters, podcasts, films, and lots more. Details here: economist.com/casement2023
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Myeloid disease exists on a spectrum, not in discrete buckets. Change my mind.
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