In the 1800s, Scottish surgeon Robert Liston became infamous for a surgery that led to an astonishing 300% mortality rate. He amputated a patient's leg in under 2.5 minutes, operating so swiftly that he inadvertently amputated his assistant's fingers and slashed a spectator's coattails. The spectator died from sheer terror, and both the patient and the assistant later succumbed to gangrene, marking the only recorded operation with a 300% mortality rate. On a separate occasion, while performing another leg amputation, Liston accidentally removed a patient's testicles along with the leg.