Organic Chemist at @Powers_lab, @TAMUChemistry, C–H Amination, C–N Coupling, N-Aminopyridinum salts
Texas A&M University
Joined January 2017
- Tweets163
- Following695
- Followers323
- Likes2.5K
Samya retweeted
Our recent paper is now published in Tetrahedron Letters! We take a deeper dive into the scope and functional group tolerance of the aza-Ramberg–Bäcklund route to 1,2-disubstituted diazenes, while also exploring some of its current limitations. We hope you find it useful!
Excited to share our latest paper, now out in Tetrahedron Letters as part of the special issue honoring Prof. Pep Cornella. @CornellaLab
“From amines to diazenes via SuFEx and the aza-Ramberg–Bäcklund reaction: scope and practical considerations.”
tinyurl.com/57t33ke6
Samya retweeted
Now live in TETL! We have introduced N-phenothiazinium amine salts as stable, tunable precursors for generating N-centered radicals. Providing a new route to aminyl radicals for use in C–N bond-forming reactions. Congrats to @iamsamya96 and coworkers.
doi.org/10.1016/j.tetlet.202…
Samya retweeted
Our latest review by @arpanpaikar95 explores advances in metal nitrene and imido complexes for N-group transfer chemistry, detailing new synthetic strategies, reactive intermediates, and their roles in catalysis. Read more:
pubs.rsc.org/qi/article/doi/…
Wow! Thanks ambeed for featuring our work. @ambeedinfo has been a huge savior for us throughout the years for their exceptional supply chain of chemicals and reagents.
🎉 𝐂𝐨𝐧𝐠𝐫𝐚𝐭𝐮𝐥𝐚𝐭𝐢𝐨𝐧𝐬 𝐭𝐨 𝐃𝐚𝐯𝐢𝐝 𝐂. 𝐏𝐨𝐰𝐞𝐫𝐬, 𝐒𝐚𝐦𝐲𝐚 𝐒𝐚𝐦𝐚𝐧𝐭𝐚, 𝐋𝐚𝐮𝐯 𝐏𝐚𝐭𝐞𝐥, 𝐃𝐢𝐲𝐚𝐬𝐡𝐚 𝐌𝐚𝐧𝐧𝐚, 𝐚𝐧𝐝 𝐌𝐞𝐥𝐢𝐬𝐬𝐚 𝐎𝐣𝐞𝐝𝐚 𝐨𝐧 𝐭𝐡𝐞𝐢𝐫 𝐧𝐞𝐰 𝐉𝐀𝐂𝐒 𝐩𝐮𝐛𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧: “𝐁𝐚𝐬𝐞-𝐅𝐫𝐞𝐞 𝐂-𝐍 𝐂𝐫𝐨𝐬𝐬-𝐄𝐥𝐞𝐜𝐭𝐫𝐨𝐩𝐡𝐢𝐥𝐞 𝐂𝐨𝐮𝐩𝐥𝐢𝐧𝐠”!
📖 pubs.acs.org/jacsat/article/…
🔬 This study introduces a nickel-catalyzed base-free C-N cross-electrophile coupling (XEC) strategy that enables efficient C-N bond formation by coupling electrophilic carbon and nitrogen partners under mild conditions.
🔹 A philicity-mismatched Ni-catalyzed C-N cross-electrophile coupling was developed using electrophilic carbon and nitrogen precursors, eliminating the need for basic additives.
🔹 The method exhibits broad functional group tolerance, including excellent compatibility with base-sensitive substrates and late-stage functionalization.
🔹 Electrophilic nitrogen precursors can be readily prepared from diverse starting materials, including C-H bonds and olefins.
🔹 A two-step, one-pot N-phenothiazination/C-N XEC sequence enables the efficient functionalization of amine-containing bioactive molecules and the synthesis of designer secondary, tertiary, and unsymmetrical diamines.
🔹 Mechanistic studies support a Ni(II)-aryl-amido intermediate as the key species responsible for promoting cross-selectivity while suppressing homocoupling.
🐝 We are pleased to see that 4,4'-di-tert-butyl-2,2'-bipyridine, a key ligand used in this study, was sourced from AmBeed.
𝗧𝗿𝘆 𝗔𝗺𝗕𝗲𝗲𝗱’𝘀 𝗯𝗶𝗽𝘆𝗿𝗶𝗱𝗶𝗻𝗲 𝗹𝗶𝗴𝗮𝗻𝗱𝘀 𝗶𝗻 𝘆𝗼𝘂𝗿 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵！
ambeed.com/search/StructureS…
#AmBeed #JACS #OrganicChemistry #CrossElectrophileCoupling #NickelCatalysis #CNCoupling #Bipyridine #ResearchTools #BuildingBlocks #Paper #Chemistry
Samya retweeted
Happy to share our latest article published in ACS Omega on photochromism of RCN-pyrrole photoswitches. My sincere thanks to my PhD advisor Prof. @RKCastellano and all the coauthors.
@CastellanoLabUF @ACSPublications
pubs.acs.org/doi/10.1021/acs…
Samya retweeted
Here is the link for the paper 🥂
pubs.acs.org/jacsat/article/…
Feels good to see C–N XEC online in @J_A_C_S . Thanks a lot to my teammates and Dave! Without you, it would not have been possible.
Happy reading!
We are excited to disclose our new work towards base-free nitrogen-centered radical XEC, now live at @J_A_C_S . Congratulations to @iamsamya96 , @LauvPatel , @mishti_2906, and Melissa for their hardwork and efforts!
doi.org/10.1021/jacs.6c05089
Samya retweeted
A disastrous decision by the @AmerChemSociety and @RoySocChem: removing graphical abstracts from ASAP articles. Bring them back!
Check out our current study on the reductive activation of N-phenothiazinium amine salts affording N-centered radicals, published in Tetrahedron Letters.
sciencedirect.com/science/ar…
Samya retweeted
Excited to share that our article from 2024 is one of the Top Viewed Article in @angew_chem. Congratulations Dave! 🎉
Read it here onlinelibrary.wiley.com/doi/…
#TopViewedArticle @wileyinresearch
Samya retweeted
Our latest @ChemicalScience paper reports the first crystal structure of hydrazoic acid bound to a transition metal. Cryogenic photolysis reveals the elusive triplet dirhodium imidogen intermediate enabling stereospecific NH aziridination of olefins. doi.org/10.1039/D6SC02258H
Excited to share our work on Organic Syntheses on the synthesis of N-pyridinium Aziridines. Happy reading and reproducing!
Synthesis of N-Pyridinium Aziridines
Submitting Authors: Samya Samanta, Hao Tan, Saikat Chatterjee, David C. Powers
Checking Authors: Michael M. Gilbert and Nathan D. Ide
orgsyn.org/demo.aspx?prep=v1…
Samya retweeted
Our latest work in @J_A_C_S captures a reactive silver nitrene in crystallo an important but elusive intermediate in C–H functionalization. The triplet nitrene species is confirmed by further spectroscopy, and computation. Link:
pubs.acs.org/doi/10.1021/jac…
Congrats to all involved!
Samya retweeted
Congratulations to Dr. Phong Thai, Ph.D. #14 from the group! Phong's insight and curiosity to learn about reaction mechanisms and developing models to study them has been a massive benefit to the lab in general and we wish him all the success in his future endeavors.
Samya retweeted
In our latest paper now out in @J_A_C_S, we report a combined experimental and computational investigation of N–H activation and C–N coupling promoted by anodically generated iodanyl radicals.
pubs.acs.org/doi/full/10.102…
Samya retweeted
Happy to share I have obtained a PhD in Organic Chemistry. Sincere gratitude to my advisor Prof. Ronald Castellano for his continuous support and guidance throughout this journey and my amazing colleagues at @CastellanoLabUF! Grateful to be a part of @UFChemistry and @uflorida 🐊
Samya retweeted
Celebrating our 100th publication around our group's 10-year anniversary with our latest review on 'Synthesis and Application of Bioactive N‐Functionalized Aziridines' in @angew_chem. Check it out!
onlinelibrary.wiley.com/doi/…
