measuring ions that fly...................
Boston
Joined April 2009
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Molecular features of human pathological tau distinguish tauopathy-associated dementias: Cell cell.com/cell/fulltext/S0092…
Honored to receive the 2026 HUPO Clinical & Translational Proteomics Award. Our lab showed tau acts as a molecular clock for Alzheimer’s: its chemical changes reveal disease stage and who’s at risk before symptoms. Proteomics belongs in the clinic. #Proteomics #Alzheimers #HMS
A machine-learning “tau code” tells tauopathies apart with >84% accuracy. That points toward blood-based diagnosis for PSP, CBD and FTLD, which have no approved therapies. Proteomics belongs in the clinic. #Proteomics #Alzheimers
ALT Thank you to past and present Steen Lab Members 2026!
Using our FLEXITau platform, we found tau modifications accumulate in a fixed order across Alzheimer’s stages, and some (like pTau217, now in an FDA-cleared blood test) appear before symptoms. #Rainwater #gatesfoundation #NIA
Huge congratulations to first authors Mukesh Kumar, Christoph Schlaffner, Shaojun Tang & Maaike Beuvink for their exceptional work!
🧠 NEW in @CellCellPress: Game-changer for biomarker development & targeted therapies. doi.org/10.1016/j.cell.2025.…
#Neuroscience #AlzheimersDisease #Tauopathy #Proteomics #PrecisionMedicine #Biomarkers #Neurodegeneration #CTE #FTD #MassSpec #DrugDiscovery #BrainResearch #CellPaper
Judith Steen retweeted
Check out our @Nature review with Tiannan Guo @guomics and Judith Steen @ionicwoman on recent paradigm shifts in MS-based proteomics - where the field stands and where its headed. #Proteomics #AI
nature.com/articles/s41586-0…
Judith Steen retweeted
You ever meet someone who you know will help change the world just by existing...then you get to know them and see how much they're actively doing to make a #betterworld. Allow me to introduce you to my friend and inspiration for all of our upcoming #MAPT projects, Linde Lee🤩 Kismet brought us together to watch Tim Miller's plenary presentation on tau-targeting therapies for @alzassociation #AAIC24
👉Add her @CureMaptFtd to see how a daughter's love and three sister's passion for finding a cure will be the catalyst the world needs for solving the mysteries of #tau accumulation in the brain. Grateful to @RCFNeuro and @virginiahughes for amplifying her voice. – at Florida, USA
Incredible trip to #AAIC2024! Thank you to @alzassociation for such an incredible week of learning and connection! Special shoutout to some of our biggest cheerleaders- @DrMariaALZ , @claire_e_sexton, @IgorCamargoF
Judith Steen retweeted
Breaking News from Capitol Hill: The senate unanimously passed the bipartisan NAPA Reauthorization Act and the Alzheimer’s Accountability and Investment Act! 🎆 Thank you, advocates, for your hard work that has brought us to this moment. Next up, the bills head to the House floor for a vote. #NAPAAct #AlzInvestmentAct
Judith Steen retweeted
A senior delegation from the Association of American Universities (AAU) visited IITB on Friday, 23rd Feb 2024 & interacted with Institute functionaries. Seen in the pic are Prof. Barbara Snyder, President AAU & Prof. Subhasis Chaudhuri, Director IIT Bombay.
Judith Steen retweeted
Looks like this deadline got pushed out…that is great for folks who wanted to submit but weren’t going to make the previous deadline. I might be in that group 👀.
❗ We still welcome submissions for a 2024 Special Issue on Single-Cell Omics Research, managed by @slavov_n & @thalexandrov. Deadline to submit is 7/31/24 ➡️ go.acs.org/7Te
rdcu.be/dxzCJ
Do you want to FLEX your Tau?
To quantify the extent of modification and the absolute amount of Tau in your samples. 1) Read the Nature Protocol 2) Do the FLEXITau
SteenTeam @BCH Kathrin Wenger, Arthur Viode, and Mukesh Kumar
#Alzheimers #proteomics
Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments academic.oup.com/brain/artic…
We hope to better understand and block this form of tau. Findings appear in the journal Brain.
#massspectrometry #proteomics #tau #Alzheimers #Neurobiology #BCH #Harvard #HMS
People with Alzheimer’s disease have tangles of misfolded tau protein in their brains. Using proteomics and other tools, we characterized an apparent precursor form of tau in the brains of people with Alzheimer’s that possibly initiates misfolding/ neurodegeneration.
Integrative systems biology characterizes immune-mediated neurodevelop... sciencedirect.com/science/ar…
Dr. Fujimura, Dr. Guise, and Dr. Nakayama, I am in total awe of your beautiful work and tenacity!
