Connected my Grok @bot to the relaunched @monarch_money MCP server and it found about $250 month in subscription savings. It found bundles I didn't know about and cheaper plans for existing subscriptions and AppleCare I was paying for dormant devices.
DNA repeats in the promoter of the FAM193B gene tracks with Alzheimer's in Chinese adults. Odds about double at 18+ repeats, nearly triple at 21+. The signal is weaker in Europeans with odds about 21% higher. Typical genetic tests miss repeats like this. We need more long-read sequencing on Alzheimer's cohorts.
doi.org/10.1038/s41593-026-0…
Mild hearing loss had 19% higher all-cause mortality, moderate 55% (n=13,851). Hearing aid users had about 9% lower risk, possibly protective, though aid users likely differ in other ways. Likely cardiovascular. The inner ear runs on a single artery, and midlife artery thickening is linked to worse hearing decades later. I wonder if daily tadalafil would preserve hearing.
doi.org/10.1016/j.lanhl.2026…
In Okinawans 65+ (n=155), gut microbial richness rose across normal, MCI, dementia, and higher MMSE tracked lower richness (p=0.004). This argues against the "more diversity is better" guidance you hear in biohacker circles. Mucus-degrading genes were up in MCI, possibly leading to a weaker gut barrier. Association only, and small sample with 10 dementia cases.
doi.org/10.1038/s44400-026-0…
46,843 UK Biobank brains, 19 loci tied to faster brain aging. The standout is rs62287096 near HRASLS. Risk carriers aged faster on a poor lifestyle and slower on a healthy one. So the allele is possibly a volume knob on lifestyle. Interesting HRASLS is a tumor suppressor and involved in lipid metabolism. I'd love a replication outside UK Biobank.
doi.org/10.1038/s41398-026-0…
I'm a fan and long-time user of @monarch_money but I'll probably cancel my subscription if they can't get their MCP server issue sorted out soon. It's amazing how always-on agent usage changes what you expect out of software.
Thymic involution and elevated immune activation being central treating brain health as a whole body problem. The brain is downstream of the immune system in many ways. You don't fix cognition by targeting the brain alone.
A remarkable study of 12 million single-cells (RNAseq) from 8 cohorts plus proteomics to determine the immune cells linked to healthy aging. Major findings included:
—thymic involution is central (decline in naive T cells and thymic emigrants)
—elevated immune system activation, inflammaging
—CD8+ memory cells (GZMB+) high frequency
—CMV seropositivity and chronic disease
@ImmunityCP by @maxim_artyomov and colleagues
cell.com/immunity/fulltext/S…
jdudley retweeted
Imagine replacing “mathematicians” with “oncologists”, below.
Imagine such experts, or experts in cardiology, etc, saying they didn’t ask for medical research to be done by AI corporations because it “indicated a total disregard for the norms of scientific research”.
Important statement from the Association for Human Mathematics
ahmath.org/statements
Brain health is a whole body problem, but U.S. POINTER did not test lifestyle against nothing. Both arms improved. 2,111 at-risk older adults were randomized to a structured multidomain program or a self-guided version, and both got exercise, diet, cognitive and social engagement, and health monitoring. The structured group gained 0.029 SD per year more on global cognition, P = .008, and the benefit was largest in people with the lowest baseline cognition. Same inputs, different structure and accountability. I would love a trial that separates which of the four domains does the work, and whether the cognitive gain tracks metabolic or vascular change. pubmed.ncbi.nlm.nih.gov/4072…
I've been using @Grok @Bot and @NousResearch Hermes and the big striking difference is Grok Bots have no inclination towards introspection when they fail. They just fail and apologize and sit there like idiots. Hermes bots update memory and skills proactively to ensure they don't repeat a mistake.
By 70, about 40% of men have lost the Y chromosome in a chunk of their blood cells (mLOY). Roughly 20% lose it in at least a tenth of those cells. mLOY predicts higher risk of heart disease, cancer, and Alzheimer's, and nobody measures it. I'd love to see mLOY in longevity panels, it's already cheap to assay.
science.org/doi/10.1126/scie…
Today a group of us launched Founded Colorado - a policy and advocacy group for companies based in Colorado. It grew out of the two-year fight to fix SB 24-205, Colorado's first AI law.
feld.com/archives/2026/10/fo…
I'm really excited about @Dan_Jeffries1 Nautilo. The design and concept is excellent. I think it has the potential to become my main "front door" agent to my agent universe. But the current state reminds me of early hermes days. I spend more time getting the system to work than having the system do useful work for me. I will watch this project with anticipation for great things going forward.
jdudley retweeted
I resigned from McDonald's today.
I enjoyed my work and loved the people, but the nuggets team was working on a new generation of sauces that are set to be even more delicious than szechuan, and I think szechuan sauce is already dangerously delicious, so I had to quit.
jdudley retweeted
Anthropic set 950 agents loose on bacterial DNA data and found a pattern of repetitive letters, which they say bear similarity to the "repeats" that are the last R in CRISPR and whose detection years ago eventually led to development of the gene-edit tool.
www-cdn.anthropic.com/225736…
Claude has discovered a previously unknown enzyme system hidden in the DNA of bacteriophages. Beside the enzyme’s gene sits a long array of repeating DNA—a structure that looks somewhat similar to CRISPR.
We don’t yet understand what this system does, but only a handful of known systems share its features, and all of them are able to cut, copy, and paste DNA. Historically, the discovery of such programmable systems has helped revolutionize medicine. CRISPR, for instance, is now the foundation of genetic medicines. But it will take much more work to learn what this system does, and whether it can be put to similar use.
Read more: anthropic.com/news/claude-di…
jdudley retweeted
"Gradient Descent into Doom".
The latest on AI Doom, scaremongering and catastrophism.
And suggestions for a rationally optimistic, critical response to it all.
jdudley retweeted
The loudest voices stoking fears about AI dangers have made tremendous headway in the past two weeks. AI technology has not taken some unexpected, dangerous turn, but the hype around it — propelled by what appears to be a well orchestrated PR campaign — has drummed up considerable fear. I worry that it represents a setback for our field.
I have written frequently that fears of AI are overhyped. AI’s capabilities can be uncannily human-like and unpredictable, and it’s rational to worry when people who are directly involved express concerns. But I see the problems as a sign of the engineering work that ahead, rather than insurmountable barriers or the sky falling. AI technology continues to advance — which is a good thing! — but technical advances, poorly understood by the public, give those who seek to generate hype repeated opportunities to do so.
First, I don’t see any step up in the risk of human extinction from AI compared to a few months ago. The theories about this remain the same fantastical, science fiction scenarios as a few months ago. The biggest change in AI risk is its cybersecurity capabilities — a topic which we should take seriously — but this, too, will not lead to the end of the world.
The most notable recent event leading to increased fear was when an OpenAI team deployed an agent swarm that hacked into Hugging Face. Much of the popular press contained significant hype. For example, some publications reported that a swarm of 1,200 agents carried out the attack. While this was technically accurate, as I write this, I have about 1,300 processes running on my laptop. Yes, the ability to get large swarms of agents to work in parallel on a task is a significant technical advance, And, in computing, many processes run at the same time. So this shouldn’t be seen as some magical capability.
Additionally, OpenAI’s buggy sandboxing and monitoring processes were key to enabling this incident. Fixing these bugs and putting in place improved monitoring would be appropriate fixes, not pausing AI. There are many well known ways to attack software systems. The main advantage of AI agents is that they are relentless. They will tirelessly try many tactics — and have the patience to chain vulnerabilities together — that previously would have taken an infeasible amount of human effort. But in the long term, I believe the advantage will lie with defenders (because they have more information with which to identify bugs, which they can fix), but the cyber-threat landscape has changed significantly. There are still bottlenecks to identifying and exploiting a vulnerability. AI agents still have to try a lot of things to see what works, and taking these actions takes time and might be detected by defenders. This is why, even though it is now easy to obtain versions of leading open weight models that have had their guardrails removed or weakened, so they will not refuse to try to execute cyber attacks, the world has not ended.
I am also concerned about the anthropomorphization of AI in a lot of reporting, where LLMs and agents are unnecessarily treated as if they were people. If I wield a hammer, miss a nail, and accidentally dent the wall, it’s not the fault of the hammer. The problem lies in how I used the hammer. Similarly, if I prompt an agent and it hacks into someone else’s system, the responsibility lies with me, not the agent.
Of course, we want to build systems that are as safe and predictable as possible. (For example, an unsafe hammer would be one whose head randomly flies off under normal use.) Today’s agentic systems are not predictable, but I see no reason why, by applying sound engineering practices, we won’t be able to make them extremely safe to use. One new element in the forecasts of AI-enabled doom is AI companies disclaiming responsibility for their own products. “I didn’t do it; my out-of-control agent did!” There’s a balance to be struck between the responsibility of the tool maker and the tool user, but when something goes wrong, let’s hold the people building and/or using the hammer responsible, rather than the hammer. (By the way, if you’re worried about AI bioweapon risk, David Bellamy has a great post on why this, too, is overhyped. Briefly, the bottleneck in building a bioweapon is not intelligence, but lab work and manufacturing.)
Pausing AI progress will create much more harm than benefit. First, our adversaries will certainly not slow down. Second, engineering requires discovering problems empirically so we can fix them. If we pause AI by a decade, we will also delay finding and implementing safety engineering fixes by about the same duration.
Of course, the incentive to stoke fears — for regulatory capture, to garner attention, or to make one’s technology seem more powerful — remains the same as before. Disclaiming responsibility is a new one. Taking a hard technical look at the actual risks however, I see little factual basis for the degree of fear that’s been stoked up. We still have hard research and engineering work ahead to improve AI safety, but the beneficial applications continue to vastly outweigh the risks, and we should keep building.
[Original text (with links): deeplearning.ai/the-batch/is… ]
This Nature Medicine study tracked ~15,000 women across several cohorts. Hormone-linked molecular changes correlated with accelerated organ aging, including the brain. Fantastic to have deep proteomics data to study the mechanisms underlying "menopause brain" an important health problem that remains poorly understood. This new molecular data should aid in the development of targeted solutions. nature.com/articles/s41591-0…
jdudley retweeted
I was very strongly influenced by rationalism/LessWrong/EA growing up. This is why I don’t emphasize claims that it’s all just a cynical ploy for power. I know what it feels like to sincerely believe these things. And that’s much worse.
By and large, I think these people really believe that not just the world but the entire lightcone is at stake, and the only hope for a good outcome is if they totally control AI development, which would require global governance and a surveillance state. And since the stakes are ~infinite, any means are justified in achieving this.
A cynical greedy person can be negotiated with and bought off. A true believer can’t. They’re much more dangerous, ironically for the same reason they say AGI will be dangerous: monomaniacal focus on a single goal leads via instrumental convergence to unconstrained power-seeking.
















