Assistant Professor of Biochemistry at the University of Toronto. Opinions are my own.
Joined May 2019
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Fantastic new preprint from @lesloew!!
Check our our new preprint. Combining measured solution rate constants and structural data to estimate bimolecular rate constants at membranes.
biorxiv.org/content/10.1101/…
Jonathon Ditlev retweeted
Check our our new preprint. Combining measured solution rate constants and structural data to estimate bimolecular rate constants at membranes.
biorxiv.org/content/10.1101/…
Preprint alert from the @Jonathon_Ditlev Lab! In this study led by postdoctoral fellow Leshani Liyanage, we discovered that missense mutations in the IDR of shank2 results in increased condensate elasticity and altered composition and function.
biorxiv.org/content/10.1101/…
In neurons with one copy of wild-type SHANK2 and a truncated SHANK2, we show that FMRP is mislocalized away from shank2 condensates, the ratio of phospho-FMRP to FMRP is increased, and expression of FMRP-targeted CaMKII is decreased, as predicted by our model.
Jonathon Ditlev retweeted
#SKResearch from @Jonathon_Ditlev is helping scientists predict phase separations in complex cellular systems.
Understanding atypical phase separations, which lead to the development of #cancer and neurological conditions, could inform new drug targets for these conditions.⬇️
From MBoC
Computational models & biochemical experiments show that the solubility product (the concentration of dilute phase proteins) is predictive of phase separation in multicomponent systems that employ heterotypic & homotypic... @jonathon_ditlev
doi.org/10.1091/mbc.E24-01-0…
In this study in MBoC, @AniChattaraj and Zeynep Baltaci spearhead our efforts (w/ @lesloew & Bruce Mayer) to develop methods to quantitatively understand and predict phase separation of multivalent binding partners using computational modeling and precise quantitative microscopy
From MBoC
Computational models & biochemical experiments show that the solubility product (the concentration of dilute phase proteins) is predictive of phase separation in multicomponent systems that employ heterotypic & homotypic... @jonathon_ditlev
doi.org/10.1091/mbc.E24-01-0…
Led by @yimeiwan together with Jordyn Smith, Rhea Hudson, and Julie Forman-Kay, we investigate the biophysical mechanism for CFTR cluster formation on membranes. We find that clusters of CFTR are consistent with phase separated condensates.
biorxiv.org/content/10.1101/…
Jonathon Ditlev retweeted
Congrats to former postdoc Felix Keber from our & @MartinWuhr lab on this fascinating paper using filtration experiments w mass spec to show that ubiquitous mesoscale condensate formation across >18% of the proteome. rdcu.be/dzXsA
Jonathon Ditlev retweeted
Hi everyone. We were made aware that many people were unable to book tickets yesterday. BPS have fixed the issue and extended our deadline - so please try again today. There are still some tickets left.
This will be an excellent symposium! Thank you @stromgaardlab for organizing it and for the invitation to share our work!
We are very happy to announce our symposium on #bimolecular #condensates - June 11 in Copenhagen. Presentations by Alex Büll, @Jonathon_Ditlev, Mingjie Zhang, @ProteinMagnus, @mz_science and Michael Wagner @dewpoint_tx
Today is the deadline to sign up for the IDP subgroup dinner!
Please share
Meet friends and eat! You can buy tickets to the IDP subgroup dinner here:
biophysics.org/store/product…
Jonathon Ditlev retweeted
IDP subgroup program co-chairs Jonathon Ditlev (University of Toronto) @Jonathon_Ditlev & Wade Zeno (University of Southern California) @ZenoResearch have put together an exciting @BPS_IDP program at the @BiophysicalSoc meeting in Philadelphia. See you all
biophysics.org/2024meeting/p…
A little late to the party, but here's a link to a new story from our groups about using the solubility product for investigating heterotypic condensation! It has been a pleasure to work with @lesloew @AniChattaraj Bruce Mayer and exceptional student Zeynep Baltaci from my group.
Check out work by @Jonathon_Ditlev, @AniChattaraj, Bruce Mayer, Zeynep Baltaci, where we show how the SP concept can help deduce new features of a well known in vitro experimental condensate system. @Pha_Tran_Papers @PappulabWashU biorxiv.org/content/10.1101/…
Thank you @bsabari for an excellent seminar and sharing exciting science with the Molecular Medicine Program at @SickKidsNews today!