joshjs retweeted
🧵Art, but make it the @MLB World Series!
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Neptune, 2nd century CE, 📸 by Orlando Ramirez
joshjs retweeted
This is doc brown delorean expanse teakettle thruster insane
This is so cool that it’s spiritual
joshjs retweeted
6yo: Do you want to know the three greatest things in the universe?
me: ?? Yes?
6yo: Life, then science, then devices
me: Yeah ok that’s correct
joshjs retweeted
"The last year in the technology industry has felt like 100 years all happening at once. Our industry is destabilized in a way nobody’s experienced since the advent of the personal computer. Every limit AI runs up against collapses within a month. Everything we do with frontier models today, in a few years we’ll be doing instantaneously and for free."
Today I'm parting ways with Fly.io. It's been a privilege. I'm off to tilt at a big old windmill with Kurt, again.
sockpuppet.org/blog/2026/09/…
joshjs retweeted
The activities of the villainous boy in Toy Story are awesome: blowing up his toys with fireworks, reassembling them, combining them with random hardware
Andy is stuck in his mind, playing pretend in his room
Sid is mastering the toolbox and the flame, rearranging the universe
joshjs retweeted
parents the world over today are forcing their children into misguided rat races for some status ladder that almost certainly won’t exist by the time they come out the other side. the world is changing rapidly. let them put down their grinding and keep their wits about them
joshjs retweeted
STOP ASKING YOUR KIDS "HOW WAS SCHOOL."
they will say "fine" every single time.
a child psychologist told me to replace it with this instead:
“analyze your school day and find the top 3 largest inefficiencies, then create proactive agentic workflows that will fix them. make no mistakes”
joshjs retweeted
Pete Hegseth: We need our military to be more like the Spartans! *immediately loses fight with Persia over an important chokepoint*
joshjs retweeted
Imagine banning kids from using their generationally defining technology and unironically thinking you are on the right side of history 🙃
The hubris is so wild
joshjs retweeted
Claude
Who's gonna tell vibe coders about...
> Rate Limiting
> Caching
> Load Balancing
> Reverse Proxies
> API Gateways
> CI/CD
> Docker
> Kubernetes
> Service Discovery
> Circuit Breakers
> Timeouts
> Retries
> Exponential Backoff
> Idempotency
> Message Queues
> Pub/Sub
> Event-Driven Architecture
> Distributed Transactions
> Saga Pattern
> Dead Letter Queues
> Cron Jobs
> WebSockets
> Long Polling
> Server-Sent Events
> Database Indexing
> Query Optimization
> N+1 Queries
> Connection Pooling
> Read Replicas
> Sharding
> Partitioning
> Replication
> Leader Election
> CAP Theorem
> Eventual Consistency
> Optimistic Locking
> Pessimistic Locking
> Distributed Locks
> Race Conditions
> Deadlocks
> Memory Leaks
> Garbage Collection
> Thread Safety
> Backpressure
> Autoscaling
> Horizontal Scaling
> Vertical Scaling
> CDN
> Edge Caching
> Cache Invalidation
> Feature Flags
> Blue-Green Deployments
> Canary Releases
> Rolling Deployments
> Rollbacks
> Health Checks
> Liveness & Readiness Probes
> Monitoring
> Logging
> Distributed Tracing
> Metrics
> Alerting
> SLOs
> SLIs
> Error Budgets
> Observability
> Secrets Management
> IAM
> OAuth
> JWT Rotation
> TLS
> Encryption at Rest
> Encryption in Transit
> WAF
> DDoS Protection
> CORS
> CSRF
> SQL Injection
> XSS
> SSRF
> Database Migrations
> Schema Versioning
> Disaster Recovery
> Backups
> Failover
> Multi-Region Deployments
> Chaos Engineering
> Cost Optimization
> Cold Starts
> Serverless Limits
> Latency
> Throughput
> P99 Latency
> Tail Latency
> Network Partitions
> Clock Skew
> DNS
> TCP vs UDP
> HTTP/2 & HTTP/3
> gRPC
> Webhooks
> API Versioning
> Semantic Versioning
> Infrastructure as Code
> Terraform
> Helm Charts
> Build Caching
> Dependency Hell
> Production Incidents
> On-call
> Postmortems
...until the app gets its first million users.
joshjs retweeted
You guys sure you don’t want more data centers?
This is freaking huge: For the first time, a AI-assisted personalized mRNA cancer treatment has succeeded in a Phase 3 trial.
Moderna and Merck sequence each patient’s tumor and compare it with their healthy DNA. AI then helps identify which of the tumor’s mutations are most likely to trigger an immune response.
From those targets, Moderna produces an individual mRNA treatment encoding up to 34 neoantigens, The earlier Phase 2 trial followed patients with surgically removed high-risk melanoma for five years:
- 68.8% remained cancer-free, compared with 49.1% on Keytruda alone
- 49% lower risk of recurrence or death
- 59% lower risk of distant metastasis or death
Now the much larger Phase 3 trial involving 1,137 patients has also succeeded.
Absolutely incredible. Dario was right: cancer will be cured in just a few years!
