@karchlab

Professor. Washington University School of Medicine. Genomics, stem cell models, molecular mechanisms of AD and other tauopathies. She/her. 🦋Karchlab

 St Louis, MO
sites.wustl.edu/karchlab
Joined March 2017
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A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies: Stem Cell Reports cell.com/stem-cell-reports/f…

A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies

In this article, Karch, Temple and colleagues describe a resource of fibroblasts, patient-derived induced pluripotent stem cells, and genome engineered stem cells with comprehensive clinical histor...

cell.com
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Michel Goedert@MichelGoedOct 1
Out now. A collaboration with Sofia Lövestam, Masato Hasegawa and Sjors Scheres. We report that tau filaments extracted from the brains of individuals with Alzheimer’s disease and corticobasal degeneration breed true in the brains of wild-type mice. nature.com/articles/s41586-0…

Prion-like transmission of human tau strains in the mouse brain

Nature - Mouse experiments show that Alzheimer’s disease and corticobasal degeneration tau filaments retain their distinct structures during templated seeding, supporting strain-specific tau...

nature.com
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Blood vessels in the brain deteriorate in Alzheimer’s, especially in APOE4 carriers. But what drives this damage? Our new study, out now in @CellPressNews , uncovers a mechanism linking APOE4 to vascular fibrosis and amyloid accumulation in the brain. 🧠🧬
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New TYP lab paper out today in @PNASNews from former PhD student Zach Augur and postdoc @FogoGarrett all about how astrocytic BAG3 coordinates Alzheimer's proteostasis proteins! Read all about it here: pnas.org/doi/10.1073/pnas.25…

BAG3 coordinates astrocytic proteostasis of Alzheimer’s disease–linked proteins via proteasome,...

Bcl-2-associated athanogene 3 (BAG3) is a mediator of chaperone-assisted selective autophagy, and in the brain, is most highly expressed in astrocy...

pnas.org
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Panos Roussos@panos_roussosSep 26
Thrilled to see PsychAD published! 🧠 A journey begun in 2019: 60+ investigators, 8 institutions, 1,494 human brains—illuminating brain aging and disease. Supported by NIA. Made possible by the generosity of donors and families. psych-ad.org/ nature.com/collections/jfibi…

PsychAD

The PsychAD Consortium builds population-scale, single-cell models of the human brain to uncover the molecular mechanisms behind neuropsychiatric symptoms in Alzheimer’s disease, related dementias,...

psych-ad.org
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Claudia Han@CeeZeeHSep 2
One unsolicited piece of advice for new #gradstudents. Don't settle on ALL of your #rotations before school starts. Use the first semester to explore. Talk to people! Check out labs and areas that you haven't considered! Go outside of your comfort zone! Let yourself be surprised!
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The FDA has cleared a blood test developed from technology invented at WashU Medicine to aid in diagnosing Alzheimer’s disease. The test, PrecivityAD2, can detect amyloid plaque biomarkers with over 90% accuracy. medicine.washu.edu/news/fda-…
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ShorterLab@ShorterLabAug 19
APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics: nature.com/articles/s41467-0…

APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet...

Nature Communications - Alzheimer’s-linked APOE variants affect the composition and plasticity of astrocytic lipid droplets. These fat storage organelles are rapidly turned over with...

nature.com
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ShorterLab@ShorterLabAug 19
MAPT splicing modulators reduce 4R tau and rescue tauopathy phenotypes in human neurons and in a mouse model | Science Translational Medicine science.org/doi/10.1126/scit…

MAPT splicing modulators reduce 4R tau and rescue tauopathy phenotypes in human neurons and in a...

MAPT splicing modulator compounds reduce 4R tau and rescue pathology in neurons derived from patients with tauopathy and mouse models.

science.org
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Joseph Castellano@JM_CastellAug 12
Happy to share the lab's new work characterizing the impact of a youth-associated protein on microglial function. Congrats to 1st author Brittany Hemmer, w/ excellent contributions f/ @philippi_sarah and all co-authors! @IcahnMountSinai @SinaiBrain Paper: nature.com/articles/s41467-0…

Youth-associated protein TIMP2 regulates microglial state and function in healthy and aged mice

Nature Communications - Aging disrupts microglial function, but factors that rejuvenate these cells are poorly characterized. Here, the authors show the youth-associated protein TIMP2 revitalizes...

nature.com
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Ran Blekhman@blekhmanAug 9
Huge faculty recruitment effort at the University of Chicago -- a division-wide, open-rank search looking to hire about 20 faculty across 5 research areas in biology. Come be our colleague! Full announcement: uchicago.app.box.com/s/ckih9…
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Anshul Kundaje@anshulkundajeAug 5
Very excited to announce ENCODE GRAMMAR (Genomic Regulatory Atlas of sequence Models, Motifs, Annotations & Rules): 3,865 experiment-specific deep learning model sets and sequence annotations for decoding human regulatory DNA. 1/
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Ania Puszynska
@AniaPuszynskaJul 30
Excited to see our work now published science.org/doi/10.1126/scie…! Lysosomal dysfunction has long been considered a hallmark of aging, but we still know remarkably little about what actually changes inside lysosomes as organisms grow old. Using rapid lysosome isolation and metabolomics, we built the first atlas of lysosomal aging across tissues.

Atlas of lysosomal aging reveals a metabolite signature shared with lysosomal storage disorders

Lysosomal dysfunction is a well-recognized feature of aging. Here, we used a suite of tools for rapid lysosomal isolation to construct a multitissue atlas of the metabolite changes lysosomes undergo...

science.org
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Brunet Lab@BrunetLabJul 29
How do lipids influence aging? We find that membrane lipid composition impacts neural stem cell aging and 'rejuvenation'! HUGE congratulations to @xiaoaizh on her paper just published at @ScienceAdvances!! 🤩🍾 And a big thank you to all our collaborators! A thread 🧵...
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Amanda McQuade@AmandaKMcQuadeJul 29
I'm excited to announce that our study, Transcriptional regulation of disease-relevant microglial activation programs, has been published this morning in Neuron: cell.com/neuron/fulltext/S08…. We discovered functional regulators of six microglia activation states!
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Bowles Lab@bowles_labJul 5
New pre-print from us! We compare two iPSC-microglia protocols, and take a look at the cell autonomous and non-cell autonomous effects of MAPT mutation: biorxiv.org/content/10.64898…

Cross-protocol comparison of iPSC-microglia reveals hypofunction contributes to neuronal vulnerab...

Progressive and chronic neuroinflammation is associated with numerous neurodegenerative diseases, including primary tauopathies such as frontotemporal dementia and progressive supranuclear palsy....

biorxiv.org
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PrudencioLab@PrudencioLabJun 26
TDP-43 subtypes shape transcriptomic signatures in Alzheimer's disease biorxiv.org/content/10.64898… @PrudencioLab Excited to share our new transcryptomics study in AD where we use quantiative measures of pathological pTDP-43 and pTau to discern changes resulting from each pathology.

TDP-43 subtypes shape transcriptomic signatures in Alzheimer’s disease

TAR DNA-binding protein 43 (TDP-43) pathology frequently co-occurs with Tau neurofibrillary tangles (NFTs) and amyloid β plaques in Alzheimer’s disease (AD), driving significant clinical heterogene...

biorxiv.org
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Studying these young Alzheimer's patients led to breakthroughs, but the funding was cut. npr.org/2026/05/07/nx-s1-575…

Studying these young Alzheimer's patients led to breakthroughs. Trump cut the funding

Families with rare gene mutations that cause Alzheimer's in middle age are giving scientists a unique window on the disease, and a quick way to test potential treatments.

npr.org
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We are excited to announce that Dr. Ana Maria Cuervo @AMCuervoLab will be our next ISMND webinar speaker! Selective #autophagy: fighting #neurodegeneration one protein at a time May 14, 2026 10-11am (ET) Host: Dr. Hui Zheng Registration: bit.ly/4tXtGzN
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Carlos Cruchaga@ccrugomMay 4
🚨 New in Sci Transl Med! science.org/doi/10.1126/scit… Our cross‑fluid proteogenomic study shows <30% of pQTLs are shared between CSF and plasma, revealing why plasma misses key biology. We identify 427 protein–trait (249 new) links. Context matters for target discovery. 🧠🔬
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Gan Lab@LiGanLabApr 16
New collaborative study in Nature Medicine! Our AcTau174 antibody powers a sensitive CSF assay from Teunissen lab that cleanly separates FTLD-TDP from FTLD-Tau & tracks cognitive decline in AD & FTLD—enabling subtype-specific clinical trial enrollment nature.com/articles/s41591-0…
Snapshot of Fig 1 from Nat Med paper

ALT Snapshot of Fig 1 from Nat Med paper

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