@lab_pollard

Neural stem cells and brain cancer - Steve Pollard Research Group @CRM_Edinburgh https://xitter.cf/t.co/3K86JQkY7Y…

pollardlab.me
Joined January 2020
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Latest work from our team led by Faye Robertson @crm_edinburgh out now in @CellReports #braincancer #glioblastoma 👇👇👇 Elevated FOXG1 in glioblastoma stem cells cooperates with Wnt/β-catenin to induce exit from quiescence
Cell Reports@CellReports29 May 2023
Elevated FOXG1 in glioblastoma stem cells cooperates with Wnt/β-catenin to induce exit from quiescence dlvr.it/Spq3M1

Elevated FOXG1 in glioblastoma stem cells cooperates with Wnt/β-catenin to induce exit from...

Glioblastomas contain quiescent stem cells expressing high levels of FOXG1. Robertson et al. identify a synergistic interaction between FOXG1 and Wnt/β-catenin signaling that drives exit from...

cell.com
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Check out this work out now in @eLife in collaboration with @wendy_bickmore lab elifesciences.org/articles/8… - Oncogene expression from extrachromosomal DNA is driven by copy number amplification and does not require spatial clustering in glioblastoma stem cells 👇👇👇

Oncogene expression from extrachromosomal DNA is driven by copy number amplification and does not...

In glioblastoma stem cells, oncogenes on extrachromosomal DNA do not cluster at distances in keeping with coordinated transcription, with amplified gene expression driven by copy number rather...

elifesciences.org
Karin Purshouse@KarinPurshouse8 Dec 2022
Do extrachromosomal DNA (#ecDNA) cluster closely with each other to drive amplified transcription of their resident oncogenes in #glioblastoma (GBM) stem cells? We have explored this in our paper out in @eLife now 1/10 elifesciences.org/articles/8…

Oncogene expression from extrachromosomal DNA is driven by copy number amplification and does not...

In glioblastoma stem cells, oncogenes on extrachromosomal DNA do not cluster at distances in keeping with coordinated transcription, with amplified gene expression driven by copy number rather...

elifesciences.org
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Our paper showing that ecDNAs in glioblastoma do not cluster and don't appear to have special transcriptional properties is out in @eLife. Great collaboration with @lab_pollard led by @KarinPurshouse @EcatTrack @mrc_hgu @EdinUni_IGC @CRUKScotland doi.org/10.7554/eLife.80207 @eLife

Oncogene expression from extrachromosomal DNA is driven by copy number amplification and does not...

In glioblastoma stem cells, oncogenes on extrachromosomal DNA do not cluster at distances in keeping with coordinated transcription, with amplified gene expression driven by copy number rather...

elifesciences.org
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Congratulations @williamsc91, postdoc in @lab_pollard!
StemCell Summer School@HydraSchool20 Sep 2022
Big congratulations to Pranay Shah, winner of the coveted Paolo Bianco #HydraXV Poster Prize Congratulations also to the two runners up, Charles Williams and Kata Krizic. Here they are being awarded their magnificent certificates by Austin Smith
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A great line-up of speakers at next week's 18th meeting of the Edinburgh Chromatin, Epigenetics and Transcriptional Regulation Network
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We had a great few days @CRUKresearch #CRUKbrain2022 last week sharing ideas and hearing of innovations from our global #braintumour community. Thanks for having us, @CRUKresearch - let the work continue! #glioblastoma #cancerresearch
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Great to see @williamsc91 present his work as part of the #FutureLeaders session, and others sharing their work during the conference @KarinPurshouse, Xinying Yeo, Erika Lo, @AlhafidzHamdan
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New preprint from the lab!👇👇👇 - Elevated FOXG1 supports exit from quiescence in neural stem cells through FoxO6 Great work from @KirstyMFerguson and the team. biorxiv.org/content/10.1101/…

Elevated FOXG1 supports exit from quiescence in neural stem cells through FoxO6

The molecular mechanisms controlling the balance of quiescence and proliferation in adult neural stem cells (NSCs) are often deregulated in brain cancers such as glioblastoma (GBM). Previously, we...

biorxiv.org
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We are hiring! Read more about our lab at pollardlab.me, and about available postdoctoral positions below 👇👇👇 jobs.ac.uk/job/CNW672/resear…
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We are looking for outstanding applicants for our 4-year PhD Studentship @EdinburghUni in collaboration with @ask_bio – one of the worlds leading gene therapy companies - focusing on development of novel gene therapies for cancer bit.ly/34oM3Hn #phd #genetherapy #cancer

Engineering novel gene therapy vectors for applications in oncology at University of Edinburgh on...

PhD Project - Engineering novel gene therapy vectors for applications in oncology at University of Edinburgh, listed on FindAPhD.com

findaphd.com
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An amazing opportunity to work across academia and industry. Thanks to #MedicalResearchScotland for supporting us. #cancerresearch #oncology #phdchat
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New preprint from @lab_pollard & @wendy_bickmore - Oncogene expression from extrachromosomal DNA is driven by copy number amplification and does not require spatial clustering biorxiv.org/content/10.1101/… @KarinPurshouse @EliasFriman @AlhafidzHamdan @genes_edinburgh #glioblastoma

Oncogene expression from extrachromosomal DNA is driven by copy number amplification and does not...

Extrachromosomal DNA (ecDNA) are frequently observed in human cancers and are responsible for high levels of oncogene expression. In glioblastoma (GBM), ecDNA copy number correlates with poor...

biorxiv.org
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Very happy to share our recent publication from postdoc @MariaAn44408423 - featured in the Editors' 'Stem Cells' highlights in @NatureComms . Lrig1 acts as a gatekeeper for #quiescence exit in adult neural stem cells. Thank you to all collaborators! nature.com/articles/s41467-0…

LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells

Nature Communications - How neural stem cells can transition between states of proliferation and quiescence is unclear. Here, the authors identify Lrig1 as a specific marker for the primed...

nature.com
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nature.com/collections/pkgzt…

Stem cells

Here, we highlight selected work employing stem cells to provide insight into development genetics/epigenetics, physiology, reprogramming, regeneration, and ...

nature.com
Delighted to share our latest work just published in @CellCellPress - new models enabling dissection of immune evasion in #Glioblastoma. A great collaborative effort
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Delighted to share our latest work published last week in @CellStemCell - available to read open access here: cell.com/cell-stem-cell/full… #glioblastoma #cancerresearch

Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants

Pediatric high-grade gliomas from different anatomical locations harbor distinct H3.3 mutations. Using human fetal neural stem cell models, Bressan et al. found that regional identity underlies...

cell.com
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Our aetiology of #GBM webinar for researchers 3rd Mar = GBM cell types & states, transcriptional plasticity, stem cells hijack fetal dev, immune evasion & open discussion with speakers. Join us! bit.ly/3befHhP @BrainTumourOrg #ACureCantWait @BrainSurgn1989 @lab_pollard
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