Translational Medicine & Neurology @UniPadova
@elamberti.bsky.social
Joined March 2022
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TPPP/p25 amyloid seeding activity as a specific biomarker for multiple system atrophy cell.com/cell/fulltext/S0092…
Tuberous sclerosis complex is associated with a novel human tauopathy rdcu.be/fgIr8
An acetylated Tau-174 CSF biomarker discriminates between TDP-43 and tau pathology in patients with frontotemporal lobar degeneration
rdcu.be/feeQg
Disrupting abnormal neuronal oscillations with adaptive delayed feedback control doi.org/10.7554/eLife.89151
Decoupling phase separation and fibrillization preserves activity of biomolecular condensates rdcu.be/e7ofj
A Biomarker-Based Classification of Corticobasal Syndrome movementdisorders.onlinelibr…
Prion-like α-synuclein pathology in the brain of infants with Krabbe disease doi.org/10.1093/brain/awac00…
Essential tremor pathology: neurodegeneration and reorganization of neuronal connections rdcu.be/eUxBt
Pathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function rdcu.be/eNi8B
Local Ionic Conditions Modulate the Aggregation Propensity and Influence the Structural Polymorphism of α-Synuclein doi.org/10.1021/jacs.4c13473
How short peptides disassemble tau fibrils in Alzheimer’s disease
rdcu.be/eJxZQ
Amyloid-β oligomers, curvilinear and annular assemblies, imaged by cryo-ET, cryo-EM, and AFM science.org/doi/10.1126/scia…
Risdiplam in Presymptomatic Spinal Muscular Atrophy nejm.org/doi/full/10.1056/NE…
Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1 rdcu.be/eAn5C
Structure of ATTRv-F64S fibrils isolated from skin tissue of a living patient biorxiv.org/content/10.1101/…
Emanuele Lamberti retweeted
🧬 𝗙𝗲𝗮𝘁𝘂𝗿𝗲𝘀 𝗼𝗳 𝗙𝗿𝗮𝗴𝗶𝗹𝗲 𝗫–𝗔𝘀𝘀𝗼𝗰𝗶𝗮𝘁𝗲𝗱 𝗧𝗿𝗲𝗺𝗼𝗿–𝗔𝘁𝗮𝘅𝗶𝗮 𝗦𝘆𝗻𝗱𝗿𝗼𝗺𝗲 𝗼𝗻 𝗠𝗥𝗜
Shown are a T2-weighted MRI scan of the middle cerebellar peduncle with signal change (Panel A, arrow; axial view), signal change in the splenium of the corpus callosum (Panel B, arrow; sagittal view) on fluid-attenuated inversion recovery imaging, and enlarged ventricles and white matter changes in a 65-year-old man with the syndrome (Panel C, axial view) on T2-weighted MRI.
Learn more in the Review Article “The Spectrum of Fragile X Disorders” by Randi Jenssen Hagerman, MD, and Paul J. Hagerman, MD, PhD, from @UCDavisHealth: nej.md/4lWrdkG
ALT Features of fragile X–associated tremor–ataxia syndrome (FXTAS) on MRI
Polyglycine-mediated aggregation of FAM98B disrupts tRNA processing in GGC repeat disorders science.org/doi/10.1126/scie…
Emanuele Lamberti retweeted
Excited that our nucleolus mapping paper just came out today in Nature! Truly an amazing study from even more amazing due of @sofiquinodoz & @jiang_lifei w/ @LafontaineLab & Sebastian Klinge and other fantastic co-authors nature.com/articles/s41586-0…
Excited to share a new preprint!
(1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function?
biorxiv.org/content/10.1101/…
Emanuele Lamberti retweeted
Triglycerides are an important fuel reserve for synapse function in the brain go.nature.com/4nvjk7k