@leadxpro

Structural Biology of Membrane Proteins

Joined September 2017
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Our LptDE paper finally got published in Nature Communications, 13, 1826 (2022). .. Here is the link to the article: nature.com/articles/s41467-0… A short blog story written for Nature: go.nature.com/37hkvV4 And the link to our previous news story: leadxpro.com/cryo-em-of-lptd…

Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into...

Nature Communications - Lateral opening of the LptDE transporter in the outer membrane of Gram-negative bacteria is necessary for insertion of lipopolysaccharides. Here, Botte et al. report a...

nature.com
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How are progresses in #AI and #structuralbiology impacting drug discovery? Find out in our latest article where we highlight advancements in five fast-growing techniques: leadxpro.com/five-opportunit…
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Announcing new talk by Michael Hennig, CEO of leadXpro, at drugdiscoverychemistry.com/
Announcing new talk by Michael Hennig, CEO of leadXpro at https://www.drugdiscoverychemistry.com/

ALT Announcing new talk by Michael Hennig, CEO of leadXpro at https://www.drugdiscoverychemistry.com/

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leadXpro has a new website! —> leadxpro.com Here you can explore our scientific developments, evolving pipeline and fantastic partnerships. We want to take this opportunity to thank all of our supporters, who have contributed to our success over the last 6 years.
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leadXpro reports the first structure of the human Kv3.1 channel, solved at 2.6 Å by cryo-EM, in the apo state and in complex with a ligand from our collaborators at Lundbeck. The structure of this important CNS drug target reveals a novel binding-site for positive modulators.
https://lnkd.in/dtQWPUz

ALT https://lnkd.in/dtQWPUz

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Binding partners are essential tools for structure research. leadXpro has patented “Pro-Macrobodies” or PMbs, novel proteins that fuse target-specific nanobodies with a maltose-binding protein via a rigid linker. The rigid linker was optimized using molecular dynamics simulations
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The remarkable gymnastics of β-barrel outer membrane proteins. The lateral opening of lipopolysaccharide (LPS) transporter LptD, as seen by cryoEM, hints at how LPS is released into the bacterial outer membrane. Find out more at: biorxiv.org/content/10.1101/…
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leadXpro is happy to report the structure of LptDE - solved by cryo-EM at high resolution - which provides structural basis for the discovery of novel antibiotics targeting lipopolysaccharide (LPS) transport on the bacteria outer membrane. biorxiv.org/content/10.1101/…
Cryo-EM map of the NgLptDE-PMb21/PMb51 complex at 3.4 Å.

ALT Cryo-EM map of the NgLptDE-PMb21/PMb51 complex at 3.4 Å.

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Dr. Michael Hennig, CEO at leadXpro, will be giving a webinar at Symeres, Thursday March 11th at 6 PM CET (9 AM PT). Register here: symeres.com/cryo-em-and-x-ra…
Webinar: Enabling Structure-Based Drug Discovery for Membrane Proteins

ALT Webinar: Enabling Structure-Based Drug Discovery for Membrane Proteins

We are hiring !! leadxpro.ch/careers/
We are hiring !! https://leadxpro.ch/careers/

ALT We are hiring !! https://leadxpro.ch/careers/

Today, leadXpro is celebrating it’s 5th anniversary! 🥳🎂🎉 A huge thank you to everyone who has supported the company, from start-up to industry leader. Thanks to this, we have produced more than 40 novel ligand-complexed X-ray and cryo-EM structures of membrane proteins.
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Axxam S.p.A, leadXpro AG and MercachemSyncom announce a strategic alliance for world-class integrated structure-guided drug discovery services for membrane protein targets. lnkd.in/dQvYK-d #drugdiscovery #drugdevelopment #discovery #chemistry #biology #medchem

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First Cryo-EM structure of the agonist complexed human TRPV4 ion-channel in the open-conformation
https://doi.org/10.1101/2020.10.13.334797

ALT https://doi.org/10.1101/2020.10.13.334797

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doi.org/10.1101/2020.10.13.3…
2.6 Å structure multidrug & toxic comp extrusion transporter could aid design of optim pharmacokinetic drug profiles goo.gl/mmB6Xg @nature
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Light controlled membrane channel high res structures #optogenetics workhorse channelrhodopsin 2 ://goo.gl/FFsnwW goo.gl/FFsnwW
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#cryoEM now with dynamics Applied to membrane receptor protein goo.gl/Z8fwgs
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The only way to improve protein structures: wwPDB OneDep goo.gl/nngG2Q Paper: goo.gl/R2ZzGa
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Relationship of receptor gymnastics with transmembrane signalling: biological function arising from time & length domains goo.gl/53RZdi
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Status of #GPCR modeling & ligand docking goo.gl/2ogPKi
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